Castrate Resistance Mechanism & Statins

[PSA680]

medicine.wustl.edu/news/stu...

Good afternoon chaps - read the above article re mechanisms leading to castrate resistance ;

In summary it appears to conclude that the PCa tumours sense the lack of testosterone due to ADT & generate their own preceded by the generation if cholesterol (albeit in mice)

I’ve read anecdotal accounts that statins have been found to help APCa patients. ( Not sure as to efficacy of this in terms of real world evidence).

Any thoughts on whether the research explains why statins may help by reducing the tumour generated cholesterol?

Apologies in advance if this is a dumb question.

kind regards brothers

Darren

[Schwah]

not a dumb question at all. Very interesting….at least to me

[EdBar]

Snuffy Myers wrote of this in his book which is now probably 15+ years old. He stressed the importance of keeping LDL cholesterol levels low because testosterone starved prostate cancer cells will turn to converting LDL into testosterone. He was always ahead of his time.

Ed

[PSA680 in reply to EdBar]

Many thanks for your reply EdBar - Snuffy’s advice seems aligned to this recent research.

[Izzygirl1 in reply to EdBar]

My husbands T went from 3 in April to 173 in June. Could his low LDL (47) be low because it’s fueling his T??

[EdBar in reply to Izzygirl1]

I don’t believe so. Seems like an ADT issue assuming he’s on ADT.

[Izzygirl1 in reply to EdBar]

yes he’s on Lupron. Started this journey a year ago. Hoping the test result is wrong.

[EdBar in reply to Izzygirl1]

I’d retest because that shouldn’t be when you’re on Lupron. If it’s still that high I’d talk with your oncologist. Could be the shot was not administered correctly and was released too quickly into the bloodstream (T level of 3 is really low). Or perhaps a bad batch, I’m not sure.

Back when I was seeing Snuffy Myers he was really big on always getting your T tested together with PSA to make sure Lupron was doing it’s job.

Ed

[Izzygirl1 in reply to EdBar]

thank you Ed…. My husbands PSA is very low…. That’s why we were surprised the T came back so high. We have a call with the MO tomorrow!

[Seasid]

The prostate cancer is hording cholesterol in order to use it to produce testosterone. I was on crestor for long time but finally I stopped statins in order to be able to generate (converter) in my skin vitamin D with the help of sunshine. My vitamin D dropped to the minimum normal level of 50 and now it is 79. Sorry I don't know the unit but I am in Australia they use moles in the unit unlike in USA.

My blood test results

[Seasid in reply to Seasid]

79 nmol/L it is up from 50 nmol/L after sunshine and stopping crestor. I feel fine now but my MO wants me to check my cholesterol for our next meeting in July 2023 (this year)

[PSA680 in reply to Seasid]

Many thanks for your reply Seasiders.

[PSA680 in reply to PSA680]

seasid! Sorry autocorrect!

[Seasid in reply to PSA680]

My MO said to me almost 5 years ago that statins not just lowering the PSA but also lowering the cancer.

I asked him that question as I was just wondering if statins maybe only lowering the PSA but not a cancer. Therefore it was good that I was on 40mg (maximum dose) of Crestor.

My MO also said that Crestor is good and it is doing a great job with cancer. You don't need Lipitor. Please note that I am only on Degarelix ADT and should reconsider statins (crestor) if I would want to add Nubeqa. I think crestor dose should be reconsidered if you introduce Darolutamide (Nubeqa). You should use your own research and consult your MO about the correct statin and the correct dosage.

At the moment I stopped statins and will do the cholesterol levels check very soon. My GP who prescribed me crestor as it is the most effective statin on the market said that we actually need cholesterol for our brains plus statin use could lead to prediabetes etc.

Therefore I hope that I don't need it anymore. I am not a doctor but I believe that maybe after so many years of blocking cholesterol production by the liver and recycling all my cholesterol deposits in my body I could give a break. I am on drug holiday now and don't intend to restart statins if my cholesterol levels are in a normal range. I am a little bit anxious about the cholesterol lab results but I have to do it for my next meeting with my MO. I really hope that I don't need crestor again.

I believe it was good that I was on statins for a long time but I just had enough. My major concern now is my osteoporosis and I want to have enough cholesterol in my body and skin to function normally in order to be able to make vitamin D with the sunshine. I am not a doctor but I feel psychologically better if could live a normal life without drugs I don't really need now. Maybe later I will have to start again for example if my PSA start to rise. Now I have an irradiated prostate and my last PSA was 0.23 on ADT alone. I wish you all the best and always make treatment decisions appropriate to your situation. My concern now is diabetes and osteoporosis.

[j-o-h-n]

You want to know if you should marry my ex-wife? Now that's a really DUMB question.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 06/16/2023 7:34 PM DST

[GSDF in reply to j-o-h-n]

😄😄😄