Degraders for Metastatic Prostate Cancer

[fsiefert]

I am thinking about signing up for a Degrader Clinical Trial (phase 1). I have metastatic prostate cancer, diagnosed seven years ago, now at 758 PSA.

Am choosing this over chemo. Anybody here have any experience or information?

Frank.

[Tall_Allen]

Which degrader (there are almost a dozen different ones in clinical trials)?

I've only seen this so far on PROTAC:

ascopubs.org/doi/abs/10.120...

This describes it:

link.springer.com/article/1...

This one was screened out:

link.springer.com/article/1...

[Blueslover]

What's a degrader?

[NotDFL]

Degrader protocols attempt to inactivate the androgen receptor.

[Seasid]

Where is your cancer and which therapy did you have until now? What your MO recommendations for further therapy? Do you have RO? Please give us more details.