While I await the results of my genetic test to see if I have the DNA repair defect to allow me to participate in the AMPLITUDE clinical trial, I have been looking at the SEs for Niraparib and they don’t look very pleasant, so I wondered if anyone has used it and has personal experience to share?
Here is the list of common SEs:
Very Common ≥10% occurrence (happens in greater than 10 out of 100 patients):
• Decrease in red blood cells that carry oxygen; this may make you feel tired or short of
breath (anaemia)
• Decrease in a type of blood cell called platelets that help stop bleeding; this may increase
your risk of bleeding (thrombocytopenia)
• Decrease in all types of white blood cells which fight infection (leukopenia)
• Decrease in a type of white blood cell called neutrophils that fight infection
• Difficulty with emptying the bowels, often because of hard stools (constipation)
• Feeling sick to your stomach (nausea)
• Vomiting
• Reduced desire to eat (decreased appetite)
• Pain in your belly (abdominal pain)
• Frequent watery stools (diarrhoea)
• Indigestion (dyspepsia)
• Sleeplessness, trouble sleeping (insomnia)
• Headache
• Feeling tired, lack of energy (asthenia/fatigue)
• Pain or burning when urinating which may indicate an infection (Urinary tract infection)
• Back pain
• Joint pain (arthralgia)
• Breathlessness or difficulty breathing (dyspnoea)
• Common cold (nasopharyngitis)
• Increased blood pressure (hypertension)
• Feeling lightheaded or like you are about to faint (dizziness)
• Cough
• Noticeably rapid, strong, or irregular heartbeat (palpitations)
Common < 10%, but ≥ 1% occurrence (happens in less than 10, but more than 1 out of every 100
patients) :
• An abnormally rapid heart rate (tachycardia)
• Infection related to a decrease in white blood cell called neutrophils that fight
infection (neutropenic infection)
• Reduced potassium in blood
• Dry mouth
• Altered sense of taste; this means that foods might taste differently than you are used to
(dysgeusia)
• Feeling anxious (anxiety)
• Mood changes to feeling sad/discouraged, listless
• Difficulty remembering, learning new things, concentrating, or making decisions
(cognitive impairment)
• Nosebleed (epistaxis)
• Rash
• Muscle pain (myalgia)
• An accumulation of fluid that causes swelling in lower extremities such as lower legs,
hands and feet (peripheral oedema)
• Swelling or irritation of the mouth (stomatitis) or of the lining of the throat, oesophagus,
stomach, intestines (mucositis)
• Inflammation of the lining of the airways (bronchitis)
• Increased liver enzymes in the blood; aspartate transaminase (“AST”), alanine
aminotransferase (“ALT”), gamma glutamyl transferase increased (“GGT”), or alkaline
phosphatase (ALP); this may be a sign of damage to liver cells
• Increase level of creatinine in your blood; this may be a sign of kidney damage (blood
creatinine increase)
• Decrease in weight
• Inflammation of the white area of the eye (conjunctivitis)
• An immune system reaction that is triggered by sunlight (photosensitivity). People
develop itchy eruptions or areas of redness and inflammation on patches of sunexposed
skin. These reactions typically resolve without treatment
• Hypersensitivity, including anaphylaxis: Hypersensitivity is when your body has an
exaggerated immune response to a drug. Anaphylaxis is a severe, life-threatening
allergic reaction.
Thanks in advance.