Researchers identify a new subtype of castration-resistant prostate cancer (CRPC).

[Scout4answers]

science.org/doi/10.1126/sci...

[Scout4answers]

This article posted by Koko Pr adds some more info:

mskcc.org/news/cryoem-msk-r...

[Fiddler2004]

Thanks for this information.... the never ending battle of modern medicine vs PC continues 🙏

[Medline]

"RESULTS...We applied RNA-seq signatures derived from the organoids to 366 patient samples from two independent CRPC datasets, which recapitulated the four-subtype classification. We found that the stem cell–like subtype (CRPC-SCL) is the second most prevalent group and is associated with shorter time under ARSI treatment compared to CRPC-AR. Additional chromatin immunoprecipitation sequencing (ChIP-seq) analysis indicated that AP-1 works together with the proteins YAP, TAZ, and TEAD, revealing YAP/TAZ and AP-1 as potential actionable targets in CRPC-SCL..."

science.org/doi/10.1126/sci...

In fact, this is the same Hippo signaling pathway whose role in prostate cancer is also well known.

pubmed.ncbi.nlm.nih.gov/310...

Interestingly, glucose regulates the Hippo pathway and specifically its downstream effector YAP.

nature.com/articles/ncb3113

Therefore, CRPC-SCL is a glucose-dependent cancer.