A word of Caution Concerning Ketogenic Diets

[cashlessclay]

"Ketogenic diets may provide short-term improvement and aid in symptom management for some chronic diseases. Such diets affect diet quality, typically increasing intake of foods linked to chronic disease risk and decreasing intake of foods found to be protective in epidemiological studies. This review examines the effects of ketogenic diets on common chronic diseases, as well as their impact on diet quality and possible risks associated with their use."

frontiersin.org/articles/10...

[Stoneartist]

Thanks for this Cashless - as always we seem to arrive at an "everything in moderation" conclusion.

[Hidden]

I don’t like it because they exclude legumes , which I love . Also nuts . Each to their own ✌️

[LearnAll]

Ketogenic diet is a fashion fad with not much beneficial effect on prostate cancer... The best diet for men with PCa is polyphenol rich lots of vegetables and fruits...because they have besides vitamins and minerals...a plethora of anti cancer substances such as carotenoids, lycopene, sulforaphanes , resveratrol etc. Fatty foods should be minimized as prostate cancer cells utilize fatty acids to grow.

[cashlessclay in reply to LearnAll]

Some background info on both diets:

ncbi.nlm.nih.gov/pmc/articl...

prevention.com/food-nutriti...

[LearnAll]

Sugar promotes cancer cell growth in MOST other cancers But Not in Prostate Cancer.Prostate cancer cells need fatty acids to grow...so Fat..particularly Saturated Fat increases prostate Cance cell growth. Do Not confuse when an article mentions bad effect of Carbs..on cancer....They are talking about other cancers..NOT Prostate Cancer.

Only in terminal stage ,prostate cancer cells learn how to use sugar. But prior to terminal stage, PCa cells utilize fats as fuel.

[Haniff in reply to LearnAll]

🙏👍

[cashlessclay in reply to LearnAll]

LearnAll, I've had a different experience with carbs than what you said: " Do Not confuse when an article mentions bad effect of Carbs..on cancer....They are talking about other cancers..NOT Prostate Cancer."

My experience is that anything resulting in an insulin spike, especially at breakfast, has ruined a working diet. Upon removal of the source of the insulin spike, the diet was once again working. There is no added sugar, nor fast carbs in my diet. The diet has slowed, stopped and reversed prostate cancer progression. Last 5 PSA's are 0.187, 0.197, 0.175, 0.164 and 0.162, down from over 0.5, three years ago.

It's currently right where I want it, as I believe that "low and stable" is more desirable than "undetectable".

[LearnAll in reply to cashlessclay]

Cashlessclay...

there are carbs and then there are carbs. Complex carbs ,slow release and fiber rich.. are different than refined carbs like sugar....The carbs in potatoes, apples, carrots, green beans .. are not harmful. Of course, anything in excess even too much Carbs can turn into fat...a process known as Lipogenesis.

The reason there is hardly any Insulin spike with carbs from veggies and fruits..is that these carbs release slowly in steady manner...there is no blood sugar spike and hence there is no Insulin spike...The sharp up and down phenomenon caused by refined carbs like sugar is called "Reactive Hypoglycemia" and that is harmful.

[cashlessclay in reply to LearnAll]

LearnAll,

I was talking about your statement . . . " " Do Not confuse when an article mentions bad effect of Carbs..on cancer....They are talking about other cancers..NOT Prostate Cancer."

Can you expand on that? When people talk about "bad effect of Carbs", they are not talking about complex carbs.

[Graham49 in reply to LearnAll]

Maybe you don't need to go ketogenic but there is evidence for the benefit of a low carbohydrate diet.

Patrick posted this 3 months ago.

A new study from Steve Freedland [1].

"... {Low-Carbohydrate Diet} intervention significantly reversed many ADT-induced metabolic changes while slightly enhancing androgen reduction."

-Patrick

[1] pubmed.ncbi.nlm.nih.gov/339...

Prostate

. 2021 May 5. doi: 10.1002/pros.24136. Online ahead of print.

The influence of low-carbohydrate diets on the metabolic response to androgen-deprivation therapy in prostate cancer

Jen-Tsan Chi 1 , Pao-Hwa Lin 2 , Vladimir Tolstikov 3 , Taofik Oyekunle 4 , Gloria C G Alvarado 5 , Adela Ramirez-Torres 5 , Emily Y Chen 3 , Valerie Bussberg 3 , Bo Chi 1 , Bennett Greenwood 3 , Rangaprasad Sarangarajan 3 , Niven R Narain 3 , Michael A Kiebish 3 , Stephen J Freedland 5 6

Affiliations collapse

Affiliations

1 Department of Molecular Genetics and Microbiology, Center for Genomics and Computational Biology, Duke University Medical Center, Durham, North Carolina, USA.

2 Division of Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.

3 BERG, Framingham, Massachusetts, USA.

4 Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.

5 Center for Integrated Research in Cancer and Lifestyle, Cedars-Sinai, Los Angeles, California, USA.

6 Durham VA Medical Center, Durham, North Carolina, USA.

PMID: 33949711 DOI: 10.1002/pros.24136

Abstract

Background: Prostate cancer (PC) is the second most lethal cancer for men. For metastatic PC, standard first-line treatment is androgen deprivation therapy (ADT). While effective, ADT has many metabolic side effects. Previously, we found in serum metabolome analysis that ADT reduced androsterone sulfate, 3-hydroxybutyric acid, acyl-carnitines but increased serum glucose. Since ADT reduced ketogenesis, we speculate that low-carbohydrate diets (LCD) may reverse many ADT-induced metabolic abnormalities in animals and humans.

Methods: In a multicenter trial of patients with PC initiating ADT randomized to no diet change (control) or LCD, we previously showed that LCD intervention led to significant weight loss, reduced fat mass, improved insulin resistance, and lipid profiles. To determine whether and how LCD affects ADT-induced metabolic changes, we analyzed serum metabolites after 3-, and 6-months of ADT on LCD versus control.

Results: We found androsterone sulfate was most consistently reduced by ADT and was slightly further reduced in the LCD arm. Contrastingly, LCD intervention increased 3-hydroxybutyric acid and various acyl-carnitines, counteracting their reduction during ADT. LCD also reversed the ADT-reduced lactic acid, alanine, and S-adenosyl methionine (SAM), elevating glycolysis metabolites and alanine. While the degree of androsterone reduction by ADT was strongly correlated with glucose and indole-3-carboxaldehyde, LCD disrupted such correlations.

Conclusions: Together, LCD intervention significantly reversed many ADT-induced metabolic changes while slightly enhancing androgen reduction. Future research is needed to confirm these findings and determine whether LCD can mitigate ADT-linked comorbidities and possibly delaying disease progression by further lowering androgens.

Keywords: 3-formyl indole; 3-hydroxybutyric acid; ADT; androgen sulfate; indole-3-carboxaldehyde; ketogenesis; low carbohydrate diet; metabolomics; prostate cancer.

© 2021 Wiley Periodicals LLC.

[Graham49]

Thanks for posting but the study does not appear to differentiate between keto diets using different types of food. The study I would like to see would investigate whether a keto and/or low carbohydrate diet based on fish and plant based oils, fish and plant based protein and plant based carbs had an effect on prostate cancer. The carbs coming from non starchy high polyphenol plant foods.