Obesity Linked to Lower Death Risk in mCRPC

[Ahk1]

Am I reading this correctly? This goes against everything I was told to do , to keep BMI very low

naspcc.us17.list-manage.com...

[treedown]

I would say that since this is confined to CRPC it should not be directly related to all PC. That said it does seem to be counterintuitive and I am not considering gaining back the weight I lost after dx.

[NWLiving]

Finally!!!! Great news all around! And around! Really around. Haha!

[maley2711]

My wife's sister was diagnosed too late with breast cancer that had moved to her back...she had back surgery of some type. Eve was very overweight, and as the cancer progressed, she probably lost 80 pounds or more...many hospitalizations. She lived 5-6 years, and had she been trim at the beginning, difficult to envision that she could have made it that long......many times when she lost her appetite during that time period. Just an anecdote, but......???

[SeosamhM]

I saw this study and had to laugh at the vision of rows of Oreos being prescribed….. In seriousness, in light of so many other documented health concerns with high BMI, isn’t the study is just another example of an odd factoid that is impossible to fit into the current larger SOC picture?

[Seebs9 in reply to SeosamhM]

Count me in for the Oreo study. Hope I'm in the group with milk.

[pjoshea13]

Many decades ago, in one of the numerous Health Professionals Follow-up Study papers, it was reported that weight gain since college increased mortality risk in a linear fashion. However, the highest mortality risk was seen in men who had gained no weight.

The study compared latest reported weight with college weight & did not look at intermediate weights. Months went by before the paper was updated. After accounting for men who had lost weight due to cancer, etc, maintaining college weight was not found to be a mortality risk factor - quite the contrary.

In the cited study: "The median follow-up for survivors was 12 months." CRPC studies tend not to be very long. Even so, over 40% of the men had died by study end.

A common feature of late-stage cancer is cachexia, which causes extreme weight loss. Perhaps a significant percentage of men were below their fighting weights when they entered the study?

I doubt that obesity per se has a survival benefit. Rather, low BMI might be associated with weight loss and mortality risk.

-Patrick

[Drphil1938]

Us fat boys don’t go down easy.🍸🍸🤠

[Seasid in reply to Drphil1938]

Agree