Metastasis with no elevated WBC, or o... - Advanced Prostate...

Advanced Prostate Cancer

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Metastasis with no elevated WBC, or other markers?

sm60 profile image
sm60
17 Replies

Just curious. Is this possible?...typical?...probable?...unlikely?...impossible?

Thanks in advance.

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sm60
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17 Replies
sm60 profile image
sm60

Anyone?

sm60 profile image
sm60

Thanks for the info. Any idea how common it is to have anything beyond very minuscule mets without any markers? Is there any reading/links on this topic you know about? Thanks in advance.

sm60 profile image
sm60

Yes. That I knew. What I would like to know is if it is common to have no markers for mets beyond the level of these micros. TIA....

noahware profile image
noahware

I would think it's possible, but probably not typical. The "typical" PC metastasizes to the bone, and so progression would raise ALP levels (specifically the BAP component of ALP).

An elevated ALP does not mean bone metastasis, but the advance of bone metastasis would usually mean an elevated ALP.

Personally, I think a very high PSA and/or a very high Gleason means that when in doubt, assume metastases, even if not yet at a clinically significant point of the disease shooting serum markers out of "normal" ranges.

sm60 profile image
sm60 in reply tonoahware

Thanks. Very helpful.

sm60 profile image
sm60 in reply tonoahware

Do you what the language for the lab request would be to request those two numbers? TIA....

COOP8 profile image
COOP8 in reply tosm60

ALP is Alkaline Phosphatase. My husband has mets to bones and ALP is one of the main things we look at to see if there’s any activity. It’s on the Comp Metabolic Panel bloodwork. His WBC was high at diagnosis, and he had elevated PSA and ALP.

sm60 profile image
sm60 in reply toCOOP8

Just had that number done up! I'm a 55 on their "normal" scale of 38-126, so I guess that's encouraging. All the best and GOD BLESS to you and your husband.

COOP8 profile image
COOP8 in reply tosm60

That’s good news! My husband has been over 200 at times. We’re just happy when his falls in the normal range!

Tall_Allen profile image
Tall_Allen

No elevated WBC is common. No elevated PSA is uncommon, but possible with certain anaplastic forms.

SalishSoul profile image
SalishSoul in reply toTall_Allen

My husband did not have elevated psa and did not have elevated wbc. That was change to nepc.

sm60 profile image
sm60 in reply toSalishSoul

Oh my. So sorry. THAT is so scary.

Avanat profile image
Avanat

Possible, yes but I don’t know how common. My husband was diagnosed last April with Stage IV, Gleason 9, multiple mets and lymph nodes yet no elevated WBC. In fact, I looked back at his results and they were only elevated once since April 2020 and that was in August when it was barely elevated. He did the genetic testing and has no genetic abnormalities. We really are all just statistics of one.

sm60 profile image
sm60 in reply toAvanat

Amazing. (AND SCARY) Thanks so much for the info! God bless and keep you and your husband!

Avanat profile image
Avanat

I forgot to mention his PSA was only 3.8 when he was diagnosed. As of May, his PSA is now .04. This disease is so different for each man. Good luck to you on your diagnosis & treatment.

sm60 profile image
sm60 in reply toAvanat

.04!!! Awesome, and congrats!! Yes, I agree. That is why "cookie cutter" "medicine" can be SO frustrating.

sm60 profile image
sm60

Fascinating, that with all the "advances" in Western medicine that we still haven't been able to identify a single marker that might stop or delay invasive techniques, fat billings and "therapies."

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