There are a few positive RCTs. Nothing earth-shattering and, by itself, green tea and EGCG likely will not change your prognosis much. But my opinion is that it is good to move the needle in the right direction (of course weigh the cost and the side effects). Green tea is cheap. I get organic green and white teas and drink tea throughout the day (white is possibly superior to green but most studies I've seen are centered on green).
I have also seen a null RCT but this is an example of one of the weak positive RCTs (I have yet to see evidence that green tea and/or EGCG is a negative for prostate cancer and if someone knows of a negative, please tell me):
That trial, comparing green tea drinking to water and black tea found "There was no significant difference in markers of proliferation, apoptosis and oxidation in RP tissue comparing Green Tea and Black Tea to water control."
Null studies and positive studies. All pretty mild conclusions. Nothing that really stands out. This, along with PubMed metastudies and trials convinces me that odds are that green tea is a mild positive. Not a game-changer. I like tea so see no harm in drinking it other than heavy metal contamination so I try to pick carefully.
Agreed. Be careful with antioxidants. Good warning for all of us. Sometimes they are fine but if you are doing a therapy that increases ROS then be careful (radiation, chemo, or drugs).
The non profit study that has been kicked back and forth here--the study that was the basis probably for Pomi-T--maybe and some urologists are having a supplement with the four ingredients manufactured for them to sell from their offices has green tea in it. Of the four ingredients, large amounts of any alone had little effect on prostate cancer cells --but when smaller amounts of the four ingredients were combined--shazaam!
That is why there are bottles of this "stuff" being sold. A little synergy goes a long way! As you have often said, one can over do something.
If you look at the video Dr. Greger posted with details of the non profit study all four ingredients including the cruciferous extract had little effect alone when dosed in large amounts but were quite effective when smaller amounts, combined together creating a synergy.
Supplements are fine. As for a cruciferous plant sources broccoli sprouts are the most effective cancer killer. The living plant has more power to heal than it's extract pressed into a pill and perhaps coated to retain freshness.
I don't get my info from videos - people make up all kinds of shit when they are not peer-reviewed. He would have to compare the results of sulforaphane alone to a Pomi-T pill. I doubt he would be willing to do that.
The best kind of sulforaphane is "cold processed" which doesn't destroy myrosinase. Myrosinase is an enzyme needed for bioavailability. Alternatively, take a pill with an uncooked broccoli floret (only a little of the enzyme is needed). Pills contain amounts of sulforaphane you are unlikely to get from eating plants.
The study isn't hard to find. Dr. Greger's video is based on the study! Greger posts relevant parts of the study in his videos. You haven't seen one?
With cooked broccoli. lightly steamed preferably, a bit of olive oil, black pepper and mustard enhances our ability to absorb it.
I really don't care if curcumin or anything else that I take interferes with PSA test results. It is more important to me that I protect myself rather than try to get an "accurate" result from a test that is "inaccurate" . In a space of four days my PSA was once 25% off. That is why my onco said at the time that is why he has reservations about the test. It can be used as a bench mark.
Looking at PSA test results and what can affect the results from an objective view, I believe that whatever one does, takes or whatever-- establishes what is now the norm for their PSA. Why would I stop taking something for a week to get a more accurate result from an often inaccurate test when I am stabile. I am living with the PSA that I have and the supps and diet I follow. If my PSA destabilizes from this, what is now my norm, then I would be concerned. The doctor, research scientist, whoever is concerned about the accuracy of my PSA by controlling what I ingest isn't paying for the disposition of my remains.
I feel that the time is ending when studies focusing on one food, supplement or whatever will be considered to be the 'final word'. We are learning just how important synergy is.
I take 2 pomi-t daily.. 3 months worth for 60 buck...about 67 cents a day...how can I go wrong plus there is a double blind study....does keep pca at bay...that can't be discerned with psa alone.
There is a fair amount of Pubmed data, metastudies, trials, and even some government RCTs that back EGCG, curcumin, sulforaphane, and pomegranate. No slam dunks that are going to wipe out cancer but every little bit helps. Even if I give something a 25% chance at efficacy, if it doesn't have many sides, I'll take the 25%.
Green tea/EGCG, coffee, sulforaphane, pomegranate juice and arils, turmeric/curcumin are all components of my "program".
If you figure out serum max times and half-life you can loosely time them so that they are all active at the same time.
If there is a study that proves there is a synergy with Pomi-T, where is it? I only saw the original RCT - but that doesn't show a synergy. It only shows that one of the ingredients (sulforaphane) has an effect, since, as I've just shown you, none of the others do.
The issue isn't absorption, it's bioavailability. First pass metabolism destroys most exogenous chemicals absorbed through the gut.
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