What sample to send for somatic gene ... - Advanced Prostate...

Advanced Prostate Cancer

22,262 members27,955 posts

What sample to send for somatic gene mutations test

dvcarola2 profile image
6 Replies

We have just seen our MO today and suggested not to send the prostate sample from my husband’s biopsy done in 2018. He prefers to have a latest sample from bone biopsy on the spine instead and send that sample to Foundation One. We have also seen an orthopedic surgeon referred by our MO who requested us to do an MRI first on T7-L5 before he does the bone biopsy. Hopefully he can extract something there.

My question is, is it better to send the bone biopsy sample rather than the prostatic sample from biopsy in 2018 to check for somatic mutation? Is it sufficient? Or should we send both sample for testing?

Also, what other tests can we do once we have the sample from bone biopsy that can help us with next treatment options? Aside from neuro endocrine tests? What else?

Not yet ready to give up.

TIA.

Written by
dvcarola2 profile image
dvcarola2
To view profiles and participate in discussions please or .
Read more about...
6 Replies
GP24 profile image
GP24

I would send the biopsy sample now to get a result quickly. Most people just send the existing biopsy samples.

If the bone biopsy is successfull you can send the bone biopsy sample later for another test. Sometimes your doctor cannot get enough tumor from the bone to allow for a successful test by Foundation.

dvcarola2 profile image
dvcarola2 in reply toGP24

The test is expensive ($3k++) because it will be sent to the US and results will come in 2-3wks later. So, we cant afford sending separate samples for testing 😔

We will probably see if we have enough bone sample from bone biopsy and maybe decide from there.

Magnus1964 profile image
Magnus1964

My research doctor said the bone biopsy would be better. That biopsy showed no cancer so he took a biopsy of from my prostate.

dvcarola2 profile image
dvcarola2 in reply toMagnus1964

Yikes. So its possible that nothing will come out of the bone biopsy test 😭 If thats the case, i will ask if we need to pay 2x if we send both the prostate sample and bone sample for testing huhu.

Tall_Allen profile image
Tall_Allen

Never send a prostate sample. As the cancer evolves and becomes metastatic, there are mutations that occur. Those mutations would not be present in the prostate sample. It is a waste of money.

There are very few genomic mutations that are currently actionable. Just BRCA, and MSI-hi/dMMR, and they are rare. There are more that are actionable based on cell histology and IHC. If you have limited metastatic material, I would get those done first.

dvcarola2 profile image
dvcarola2 in reply toTall_Allen

Thanks for the advise TA. Yes our MO said its better to send the latest bone biopsy sample for testing instead of the prostate sample from when my husband was diagnosed in 2018.

Im just hoping and praying that the doctor will be able to extract enough specimen for testing and that we will be able to get some actionable mutations. We will advise our MO to do IHC and neuroendocrine test as youve mentioned. Always grateful for your opnion! Thank you!

Not what you're looking for?

You may also like...

25 Somatic Gene Mutations!

Hello everyone, It's been a couple of months. My dad, newly diagnosed with metastasized PC, has...

Anne for Ron Update

Hello Everyone: first my best wishes for all...We are rooting for everyone. So Ron Had his...
rfurgason profile image

APC doing end run on Docetaxel

I started second series.of docetaxel after Talapro2 trial began failing (Xtandi with talazoparib or...
Maleko808 profile image

Follow up after MO Visit and PSMA Pet

I have taken a lot of information from this group and so very much appreciate it... Here is where...
Keeper70 profile image

Can a MRI, Cat Scan or X-ray, reveal a new met? Which one is better?

My husband is Gleason 8 DX July 2022 Original PSA 07/96/2022 942.40 Last Check PSA...

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.