"... thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA) ..."

[pjoshea13]

New study from Hungary [1].

Odd to think that the thyroid stimulating hormone (TSH) might affect PSA, or vice versa.

"PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35-4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639-2.338] vs. 0.920 [0.508-1.826] ng/ml ...). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH."

"The finding that hyperthyreosis {Hyperthyroidism} might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients."

A 2005 study from Spain [2] reported that:

"Our data show that ADT seems to alter the thyroid function test. A statistically significant increase in TSH serum level and a decrease in FT4 serum level were detected in patients under ADT. However, only a mild hypothyroidism was detected in about 2% of the patients with prostate cancer, independently of ADT."

In the U.S. (if not elsewhere), a PCa diagnosis increases one's chance of a thyroid cancer diagnosis - & vice versa. This has been dismissed as due to over-screening, since the two cancers are over-detected. &, after all, what could be the connection? Well, iodine deficiency comes to mind, but PCa researchers show little interest in iodine.

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/314...

Orv Hetil. 2019 Sep;160(35):1376-1379. doi: 10.1556/650.2019.31340.

[An inverse significant association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA) blood levels in males 40-75 years of age 40-75 years of age].

[Article in Hungarian; Abstract available in Hungarian from the publisher]

Tóth Z1, Gyarmati B2, Szabó T3, Vásárhelyi B3.

Author information

1

Urológiai Osztály, Uzsoki Utcai Kórház Budapest.

2

Szülészet-Nőgyógyászati Osztály, Uzsoki Utcai Kórház Budapest.

3

Laboratóriumi Medicina Intézet, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Nagyvárad tér 4., 1089.

Abstractin English, Hungarian

Introduction: Recent experiments and clinical studies indicate the contribution of thyroid hormones to prostate pathology. Aim: In our retrospective analyzis of university patient population, we evaluated the association between thyroid stimulatory hormone (TSH) and prostate specific antigen (PSA). Method: From the Laboratory Information System we retrieved the data of male patients between 40 and 75 years of age who had been subjected to simultaneous TSH and PSA measurements during the last 12 years (n = 7279). The association between logTSH and logPSA levels was tested with multiple regression analysis and adjusted for age. Results: Significant associations between logPSA and logTSH and age (r = 0.297 and 0.472, respectively) were detected. PSA levels were higher in patients with TSH below (n = 405) than in those with TSH within reference range (TSH 0,35-4,95 mU/ml) (n = 6698) (PSA level: 1.118 [0.639-2.338] vs. 0.920 [0.508-1.826] ng/ml, p<0.016). Based on estimates, a 10% decrease in TSH is associated with a 0.42% increase in PSA levels in our population. This corresponds to a 42% increase in PSA levels in the same patient if he would present with 0.2 mU/ml instead of 2.0 mU/ml TSH. Conclusion: The finding that hyperthyreosis might be associated with higher PSA levels indicates that PSA reference ranges would differ in hyperthyreotic and in euthyreotic patients. Probably the PSA clinical decision limits is also recommended to be modified according to the patient's thyroid status. Orv Hetil. 2019; 160(35): 1376-1379.

KEYWORDS:

PSA levels; PSA-szint; TSH levels; TSH-szint; pajzsmirigyfunkció; reference range; referenciatartomány; thyroid function

PMID: 31448641 DOI: 10.1556/650.2019.31340

[LearnAll]

It makes sense. I trust Hungarian researcher as they are not as polluted by uncontrolled greed. Cabbage and Cauliflower is known to reduce levels of thyroid hormones...may be

Sulforaphane in these cruciferous veggies might have a link with all this.

[Grumpyswife]

Husband was finally diagnosed with hyperthyroidism causing his weight loss. His PSA has been increasing and we are still titrating the thyroid medication.

[Hidden]

I've already commented on urologists lack of interest in iodine when it comes to treating peyronies. I'm wondering now -- should I stop taking my iodoral supplement for a while before my next blood draw for a PSA test?

[pjoshea13 in reply to Hidden]

Without knowing how long it would take to return to your old iodine status, what would be gained?

It would be interesting to see if your replete status has any effect on your PSA.

-Patrick