I'd like to know what others (especially the scientists in this group) think about the combination of green tea extract and Advil. It's cheap with virtually no side effects. What's not to love?
See more at ncbi.nlm.nih.gov/pubmed/182...
Synergistic cell death by EGCG and ibuprofen in DU-145 prostate cancer cell line.
Nice find. I take these separately so why not together.
IT,
You are a chronic user of Advil? If not, see my response above before upping your use.
-Patrick
Not a chronic user but I've taken it daily for the last couple of weeks to deal with a recent rotator cuff injury that I inflicted while working out.
If the study suggested that Advil can increase prostate cancer risk, then I've got no worries as I'm all stocked up. However if it can make Pca more aggressive, then I need to find another solution.
I recently bought some CBD capsules (not hemp) and they work but I need to take 60 mg to realize the effect and at $10 per day, this adds up quickly.
So somehow I need to find a balance between controlling pain and inflammation and feeding this disease.
You should ignore that because humans are not mice and lab studies do not translate well to human biology. Instead. look at clinical studies.
In this one, they found that "Administration of high doses of lycopene, Green Tea Catechins, and selenium in men harboring HGPIN and/or ASAP was associated with a HIGHER incidence of PCa at re‐biopsy and expression of microRNAs implicated in PCa progression at molecular analysis. The use of these supplements should be avoided."
onlinelibrary.wiley.com/doi...
Other clinical studies have found no effect:
bmccancer.biomedcentral.com...
pagepressjournals.org/index...
It has been found to interfere with the effectiveness of radiation, and may interfere with the body's natural mechanism to destroy cancer cells.
That’s a bit discouraging because I have been following Snuffy Meyers’ book advice and he strongly encourages those supplements, particularly lycopene. Of course, he also advocated for high doses of vitamin D which we now know is not beneficial.
Snuffy recommended high dose vitamin to me to maintain strong bones while on ADT and to help heal sclerotic lesions left behind by bone mets. Healing these areas was one of the things he wanted en route to a durable remission. Dr. Sartor reviewed and has no problem with it.
Ed
Vitamin D and Calcium should only be supplemented when blood levels are too low. Vitamin D has not been found to increase bone health in people with adequate serum levels, but it probably won't hurt you in small amounts.
pcnrv.blogspot.com/2018/07/...
Serum levels may become inadequate while taking bone preserving agents and should be carefully monitored. I have no idea what effect it may have on sclerotic lesions, but it probably won't hurt.
I have Dr. Sartor review my supplements when I see him every 6 months, when he has a problem with something he lets me know. So far the only thing he has advised against was B12.
Most supplements do nothing. A few are harmful. Very few are beneficial.
Well so far so good so if it works don’t fix it.
Be careful of out-of-date books. Our knowledge about benefits and harms changes as we get results of clinical trials.
Vitamin D3 is not beneficial for what? It is beneficial in other ways, including a lower chance of death f you get covid.
55ug of selenium is a joke, 1 brazil nut has 50ug. Now 450ug of selenium would be significant. 600mg green tea egcg, is the equivalent of about 4 cups of green tea per day. Again, not significant. Sample size was too small, no mention if other modalities were included as well to modulate final outcome.
Yes, it was a small study - but why do a larger one when HARMS are noted already? Presumably they used doses that are commonly taken. Why would anyone take larger amounts of substances that are already harmful in smaller amounts? It was a randomized, placebo controlled study so "other modalities" is irrelevant.
There have been a number of PCa-NSAID studies & I don't recall ibuprofen standing out, but, mostly, they were concerned with prevention rather than progression.
A 2016 study from Finland should make one wary [1]:
"Materials and methods Participants in the third round of the Finnish Prostate Cancer Screening Trial were sent a survey on possible PCa risk factors and 11,795 out of 12,740 (93%) men returned the questionnaire. PCa cases were identified from the Finnish Cancer Registry. Results During the median follow-up of 6.6 years, 757 PCa cases were diagnosed and 21 men died from PCa."
"Weekly use of ibuprofen was associated with an increased risk of PCa overall (HR 1.43 ...) and with metastatic PCa (HR 1.49 ...) compared to less frequent use."
There is no mention of any of the other common NSAIDs in the Abstract.
In the Prostate, Lung, Colorectal, and Ovarian [PLCO] Cancer Screening Trial [2]:
"There was no evidence of an association between ibuprofen use and prostate cancer risk."
"The daily use of aspirin only was significantly associated with lower risk of cancer HR ... of 0.91 ... Interestingly, the daily use of aspirin plus ibuprofen was associated with excess risk of prostate cancer 1.55 ..."
In general, aspirin is associated with lower risk, but I think there is an issue with aspirin. The chronic use of NSAIDs implies chronic pain - & inflammation. One might expect PCa risk to increase with inflammation, & over-the-counter NSAIDs might not adequately control the problem (usage is a response to pain - not markers of inflammation). But many men without chronic pain take low-dose aspirin (for supposed cardio benefits). Such men do not have the excess risk associated with chronic inflammation. (Also, aspirin's inhibition of platelet aggregation is thought to reduce the risk of PCa metastasis.)
Aspirin aside, I'm not convince that there is a case for regular use of NSAIDs in PCa.
-Patrick
I drink about 3 L green tea daily, or use about 8 tea bags, but I doubt its enough and the nih link does not say how much extract you need, or how much you'd have to drink to kill Pca cells. Maybe its 50 litres.
I do like green tea though.....
Patrick Turner.
Drink green tea? I'd rather be waterboarded.
Good luck, Good Health and Good Humor.
j-o-h-n Sunday 12/23/2018 7:52 PM EST
funny.. you made me laugh.. thanks
My pleasure.....
Good luck, Good Health and Good Humor.
j-o-h-n Monday 09/09/2019 11:58 AM DST
It's the only thing that gives me sustained energy. After covid? and levaquin I have energy for only a few hours a day but the matcha green tea powder makes me feel like i did before cancer and radiation and covid and levaquin, at least for an hour or two. Coffee doesnt work for me anymore.
Wow!!! If it comes in an acrylic base I would use it to paint my kitchen cabinets....
But for you it does wonders and that's what counts.
p.s. I owe you a response to your recent request (I didn't forget)....
Good luck, Good Health and Good Humor.
j-o-h-n Sunday 01/31/2021 7:22 PM EST
lol - try the green tea ice cream maybe 
Oh thanks for remembering the other response
Vitamin C combined With Green Tea
"Beet Extract significantly and concentration-dependently inhibited DU145 of prostate cancer cells at all concentrations"
green tea trial for prostate cancer
