Abiraterone - "Prostate cancer trial ... - Advanced Prostate...

Advanced Prostate Cancer

22,262 members27,955 posts

Abiraterone - "Prostate cancer trial stuns researchers: 'It's a once in a career feeling' "

JLS1 profile image
JLS1
5 Replies

Hoping and praying for encouraging news like this to keep flowing from these conferences:

News just out today, from the big ASCO (American Society of Clinical Oncology) conference going on now, in Chicago: events.jspargo.com/ASCO17/P...

theguardian.com/society/201...

“Abiraterone not only prolonged life, but also lowered the chance of relapse by 70% and reduced the chance of serious bone complications by 50%,” James said. “Based on the magnitude of clinical benefit, we believe the upfront care for patients newly diagnosed with advanced prostate cancer should change.”

"If you have just been diagnosed with metastatic prostate cancer and your doctor wants to start you on ADT (androgen deprivation therapy, such as Lupron), which shuts off the supply of testosterone and other male hormones, ask for abiraterone as well. It could extend your life for years.

But wait, you might be thinking (and your doctor might be telling you): abiraterone, which targets the androgen receptors, is a second-line hormonal therapy drug. It’s supposed to be given if ADT stops working. Or, if ADT stops working, you’re supposed to start chemotherapy with docetaxel. "

Global Congress on Prostate Cancer

The fifth Global Congress on Prostate Cancer will bring us to Lisbon, Portugal.

During this major educational multidisciplinary event purely focusing on prostate cancer, we invite you to actively contribute in the discussion on how to deal with dilemmas when managing prostate cancer.

28 - 30 June 2017 - Lisbon, Portugal

Written by
JLS1 profile image
JLS1
To view profiles and participate in discussions please or .
Read more about...
5 Replies
Blair77 profile image
Blair77

What implications would this study have if you started docetaxel in conjunction with Lupron based on the CHAARTED trial? Is this trial saying zytiga+ Lupron is better then docetaxel+Lupron? My husband started the combo of docetaxel and Lupron in March.

TommyTV profile image
TommyTV

I joined the randomised Stampede trial arm G Abiraterone plus ADT (Zoladex) 5.5 years ago. I knew a couple of weeks ago that something was about to be announced. My Oncologist, although unable to comment at that time, said some words that will stay with me.

"You bought a lottery ticket and won first prize"

I had PSA >600, 7 major bone mets, Gleason 7. My PSA has been <0.1

Ever since commencing treatment.

This is truly wonderful news for all of us, those just starting out on our journey, and those of us who are old timers.

Good luck everyone.

GaRick profile image
GaRick in reply toTommyTV

June 2015 RRP, Gleason 9. Started Lipton right after surgery. 36 days of radiation and PSA was down to .05. sept 2016 PSA dramatically up to 11 and 25 a month later. Started in Zytiga and in 30 days PSA >0.01 (undetectable) and it has stayed there. Also just finished 6 Radium 223 infusions. CT and bone scan last week. No lymphatic or organ involvement and scan showed lots of sclerotic -scarring - activity. mO and RO characterized it as an 'exquisite' reaction. 1st person in our area to have these at this stage. I love that phrase about winning the lottery. So grateful

Apollo123 profile image
Apollo123 in reply toTommyTV

You have just made my day with your feed as I've been on ZYtiga since day one as the result of the stampede trial. Undetectable PSA within two months.

This is very cool news. Although I started Zytiga after Lupron began to fail, this may still help me somewhat. Being 7 1/2 years into it, I feel better today than I've felt in years. The drawback is, my PSA is inching up ever so slowly.

Joe

Not what you're looking for?

You may also like...

Abiraterone in Metastatic Hormone-Sensitive Prostate Cancer

TAKE-HOME MESSAGE •This is a post-hoc analysis of the STAMPEDE study, where the outcomes of...
Balsam01 profile image

Statin use in advanced PCA with ADT or abiraterone/enzalutamide

New meta-analysis below [1]. Does statin use affect mortality when used with classic ADT or...
pjoshea13 profile image

Exclusive Fasttrak - Apply to clinical trial testing a new immunotherapy for prostate cancer!

What if you could get access to free immunotherapy treatment using Nivolumab, also known as OPDIVO?...
Darryl profile image
Partner

Anti-Androgen Abiraterone Acetate Improves the Therapeutic Efficacy of Statins on Castration-Resistant Prostate Cancer Cells.

New cell study [1] below. I have used Simvastatin for many years to try to prevent the production...
pjoshea13 profile image