Metabolic syndrome is associated with advanced prostate cancer at time of retropubic prostatectomy.

[pjoshea13]

New Italian study [1] below.

It's known that men who become diabetic have less PCa risk. Considering that diabetics have a higher risk of every other form of cancer, it seems to me more logical to say that:

... an untreated pre-diabetic condition is common in older men & increases the risk for PCa.

The metabolic syndrome, although it might never progress to diabetes, is a pre-diabetic condition.

[2] "About 34 percent of adult Americans are estimated to have it. Risk of developing metabolic syndrome increases as we age."

"Metabolic syndrome is a group of risk factors that raises risk of heart disease, diabetes, stroke, and other health problems. It is diagnosed when any three of the following ve risk factors are present:

• High blood glucose (sugar)

• Low levels of HDL (“good”) cholesterol in the blood

• High levels of triglycerides in the blood

• Large waist circumference or “apple-shaped” body

• High blood pressure

Metabolic syndrome is a serious health condition.

"

My opinion is that the triglycerides:HDL ratio is most directly related to PCa risk. It is a measure of insulin resistance.

[3] "According to the American Heart Association, 47 million Americans have {the metabolic syndrome}."

[4] "50 percent of those 60 years of age or older were estimated to have the metabolic syndrome in 2011-2012"

In other words, we have a better than even chance of having MetS as we enter the PCa years.

In the new study [1]:

"Median age and preoperative PSA levels were 66 years ... and 7 ng/ml ..., respectively."

"Median BMI was 26.12 kg/m2 ... with 56 (16%) obese (BMI ≥ 30 kg/m2) patients and 87 (25%) patients with MetS."

"MetS was significantly associated with advanced PCa (45/87, 51% vs 81/262, 31%; ...) and high-grade disease (47/87, 54% vs 98/262, 37%; ...)."

...

How best to reverse MetS?

Crazy for me to attempt an answer, but I would target triglycerides. For some, that will mean increasing the fat:carbohydrate ratio. Dean Ornish type diets increase triglycerides.

For men not on ADT, get a testosterone [T] test. Low T is responsible for some MetS, & it is extraordinarily difficult to reverse MetS with low T.

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/273...

[2] heart.org/idc/groups/heart-...

[3] webmd.com/heart/metabolic-s...

[4] sciencedaily.com/releases/2...

[Fude]

BS

[joeoconnell]

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