EMA Accepts Conditional Application for ANCA... - Vasculitis UK

Vasculitis UK

7,759 members6,736 posts

EMA Accepts Conditional Application for ANCA Treatment Avacopan

amms43 profile image
3 Replies

I suffer from MPA and am currently on my third year of 6 monthly infusions of Rituximab + Prednisolone after an unsuccessful year of Cyclophosphamide. This keeps the worst of my symptoms largely at bay though they still grumble away in the background.

Does anyone know if Avacopan, when/if approved, may be suitable for treatment of MPA and a possibility to look forward to?

Written by
amms43 profile image
amms43
To view profiles and participate in discussions please or .
Read more about...
3 Replies

Hi,

There is a clinical trial at the moment ( sorry can't remember the name of it ) to compare avacopan with prednisolone in newly diagnosed ANCA associated Vasculitis.

It's hoped it will be as effective as prednisolone but with less side effects.

ZiggyDiego profile image
ZiggyDiego

I'm in the avacopan trial (ADVOCATE) and you might be eligible to participate if you have a relapse, like I did. There's more details here advocateclinicaltrial.com/#...

As already said, it's for ANCA associated vasculitis so includes MPA I assume.

It is a bit weird being on the trial as I don't know if I'm taking avacopan or prednisolone. I've had 4 Rituximab infusion and I've experienced some improvements but it's a slow business. If I am on avacopan it certainly hasn't had any miracle effects!

amms43 profile image
amms43 in reply to ZiggyDiego

Thank you for the replies. I will ask at my next clinic appointment if I could be useful for this trial.

You may also like...

Symptoms of GPA or MPA

mum had MPA I wondered if anyone who has GPA (Wegeners) or MPA has experienced similar symptoms to...

mpa vasculitis info please!

site. diagnosed in April of this year with microscopic polyangitis (mpa). i'd like any information...

Prognosis MPA Vasculitis

expectancy for MPA ( microscopic polyangitis). I keep seeing references to 2 years and 5 years. Is...

MPA in remission - what are these symptoms?

have MPA and am on azathioprine and prednisolone, and am officially in remission after a years...

Microscopic Polyangiitis

I was diagnosed with MPA in 2007. You have to experience its symptoms to understand just how painful