MTORi v Tacrolimus

[Notso]

My transplant was about 3.5 years ago, my brother was the live donor (pretty good match).I have started producing a large crop of BCC's and increasingly SCC's. My neph. Is thinking about taking me off Tacrolimus and putting me on MTORi instead.

Is anybody on this stuff or know much about it?

[Denise-80]

Hi - I would suggest researching the anti-rejection drug, sirolimus. I’ve read studies that it has shown to decrease skin cancer occurrence. I take it with low dose pred and belatacept. I think some take just the sirolimus though. I don’t know about differences between tac and myfortic

Best wishes.

D

[SLP2005]

I take both Sirolimus and Tacrolimus, low dose. I was taken off Myfortic due to increased risk of SCC. Sirolimus inhibits MTOR considering anti-tumor growth. I’ve been taking Sirolimus since February of 2022.

[TaffyTwoshoes27]

May I inquire how you got the carcinoma diagnoses? Does your transplant hospital test for these or do you have a dermatologist?

I’m curious because I’ve never seen any testing for carcinoma through my transplant facility.

[Notso in reply to TaffyTwoshoes27]

Hi. I'm in Australia and once a year the renal team organise a barrage of tests including dermatology. All are done through our public health system and are done to monitor for all the side effects of the medications.

[TaffyTwoshoes27]

Oh I see: government health insurance in the Kingdom. We still don’t really have that in the U.S.

I’m going to get a Dermatologist soon — after a psychologist and Endocrinologist! Too many doctors! Good luck and prayers to you!