Does anyone know of any medical papers where there is evidence that rT3 blocks receptors but does not activate them?

[kosmickaz]

I would like to pass this info to the Endo that I recently had an appointment with. Thank you

[helvella Administrator Thyroid UK]

I have never been able to locate a pukka paper which supports this claim in clear words.

This paper speculates that it might be the case - but also speculates the same about the cell membrane and affirms that rT3 blocks deiodinase type 2 activity.

ncbi.nlm.nih.gov/pubmed/151...

Don't know what to make of this:

ncbi.nlm.nih.gov/pubmed/303...

There are only about 1700 papers that even mention rT3!

ncbi.nlm.nih.gov/pubmed?ter...

Happy reading.

Rod

[kosmickaz in reply to helvella]

Thanks Rod!

I haven't been able to find a paper that clearly supports it either Brain is also not good at the moment (last 5 years) at reading through pages of complex text...

perhaps that what these Endo's rely on...once bright and capable people no longer that effective at rational discussion...! LOL - Which in turn lets them get away with care that largely is non-sensical - at least in my experience...

How can we begin to address these issues? I feel that only in large numbers can we hope to tackle the crazy over reliance on blood tests (TSH, T4) - I have been told - despite my toenails falling off, being constipated, have dry skin and a moon-like puffy face (amongst many other clear signs of lingering hypo symptoms) that I have CFS and the thyroid isn't a problem...

[poing]

You might be able to come up with something if you look in pubmed, but the papers containing the type of info you seek are way too complicated for me. I had a quick look, but the only papers that I could understand were about low total T4 and high reverse T3 - togther they can be a useful indicator of nonthyroidal illness.

ncbi.nlm.nih.gov/pubmed/443685