I have Hashimotos and a histamine intolerance (unable to breakdown the DAO enzymes) . I have been called to have my covid 19 vaccination due to my autoimmune disease. I told the Dr I am concerned that I have been unable to find any information on whether or not the vaccination is safe when I have a histamine intolerance but they haven't been able to give me any reassurance. I react to foods high in histamine (particularly things like paprika, vinegar etc) and my throat feels like its closing and I have tingly sensations in my throat and arms. They initially said people with allergies should be careful but as it is the histamine that triggers my reaction, I am not sure if anything in the vaccine will trigger that response.
I spoke to my Dr's surgery and they just told me to do my own research.. Helpful!
Does anyone have any thoughts on this or have had the vaccine with the same conditions?
Many thanks
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katielou1980
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Wikipedia says that histidine is a precursor of histamine. I don’t know if you’d react to the histidine, but you might prefer the Pfizer jab to the AstraZeneca one.
That's so helpful as I was steering towards the Astrazeneca vaccine. Glad I didn't as the slightest exposure to histamine causes a big reaction! Thanks so much for taking the time to look into it
Hello, same problems here and very allergie in general. I had the 2 pfizer shots, the second one with suite strong réactions Like fever, headache, runny nose, Warm and swollen âme, pain in the articulations, that for 2 days. It is quite banal apparently for people with auto-immune problems, and proves that you body is sending a bazooka to kill a mosquito. But it is better to be unconfortable for 2 or 3 days than to have the covid in our situation where we risk maybe more than the average to suffer a cytokine reaction.
Thanks so much, I really appreciate your reply. I've been really worried about a more severe reaction. Flu like symptoms I can handle, it was the risk of flooding my body with histamine that worried me. Thank you
OH MY Goodness - do you own research?!!Wow. Surely they are best placed to do the research required (or maybe not)!
Are there any national organisations / charities etc who can provide clinic advise on this? Perhaps you could contact a vaccination centre for advice as when I had my jab, the big question was ‘do you have known allergy or reactions’ and you would have to tick ‘yes’. And they might then refuse you the jab.
Is there a local hospital vac centre you can contact?
Hello, I have MCAS and have been similarly worried. I received the AZ vaccination and took the precautions recommended by the relevant charities. Take citerazine or equivalent at least 30 mins before apt, check for ingredients that you know you react to (this wasn’t possible until I was in the cubicle with AZ confirmed but I had anticipated that), if you have throat closing or near anaphylaxis stay at the centre for 30 mins after not 15. I don’t have an epipen so had a detailed discussion with the doctor administering.AZ is more likely for those of us vaccinated in non-medical centres, mine was a sports centre.
I had my first jab last week, Pfizer, I tend to react with lots of things, not extreme but bad enough. I was fine, slight sore arm the following day but not as bad as the flu jab. Other than that I felt like I was coming down with a cold for the one day, but nothing after.
Forgot to sayAdvice from my consultant is always to have liquid piriton, chlorphenamine malate, with me a use basically with a straw if anything happens.
Plenty of advice and experiences in relevant FB groups or see charity websites.
Official advice in England, updated 12th February 2021, is:
Contraindications
There are very few individuals who cannot receive the Pfizer BioNTech, Moderna or AstraZeneca COVID-19 vaccines. Where there is doubt, rather than withholding vaccination, appropriate advice should be sought from the relevant specialist, or from the local immunisation or health protection team.
The vaccine should not be given to those who have had a previous systemic allergic reaction (including immediate-onset anaphylaxis) to:
●● a previous dose of the same COVID-19 vaccine
●● any component (excipient) of the COVID-19 vaccine e.g. polyethylene glycol
A very small number of individuals have experienced anaphylaxis when vaccinated with the Pfizer BioNTech vaccine. Following close national surveillance, the MHRA is no longer advising that individuals with a history of anaphylaxis to any vaccine, medicine or food do not get the vaccine. Anyone with a previous history of allergic reactions to the ingredients of the vaccine should not receive it, but those with any other allergies (such as a food allergy) can now have the vaccine.
Hi Katielou1980 , you have worried me. Can i ask ,what do you mean exactly that you are histamine intolerant? Is that the same as for example if you get stung by an insect you get a massive histamine response swelling/feeling unwell, whereas others would just experience a small swelling reaction?
Or did you mean you react to high histamine foods?
I too was favouring A Zeneca Vacc ,as there is no data for us Hashi/Dio2 or other immune disorders as yet re a mRNA gene Vaccs.
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