Bloods Results help please: Afternoon, I am... - Thyroid UK

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Bloods Results help please

goofball profile image
28 Replies

Afternoon,

I am looking for more advice please, as asked for another thyroid function test due to putting on a few pounds, despite increasing excercise.

Just had my recent bloods back and two, nearly three results are 'out of reference range'.

T4 -22.6 (12-22)

TSH -4.4 (0.27-4.2)

T3 -3.3 (3.1-6.8)

I am on a dosage of 75 Levothyroxine and have Hashimoto's. I am taking Vitamin D, and supplimenting B12 as my last reading was 376 (180-914). My Ferritin and Folate are also near to the bottom of the range. I think that the TSH has lowered as previously it was 5.8, due to taking the B12. I have no recent results for Ferritin, B12, or Folate.

I have been asked to call the doctor as my results are 'borderline'.

I do not really know what to discuss as we all know that I need T3 supplimenting, yet the doctor will only want or will only be able to up my Levo to 100, which of course will increase my T4 ( it did last time), and not tackle the problem of the T3 due to it being just within tolerance. I have previously been to an Endocrinologist who was no help what so ever.

Any ideas apart from a referral please?

Once again thanks for any help.

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28 Replies
SeasideSusie profile image
SeasideSusieRemembering

goofball

When did you take your last dose of Levo before the test? It's unusual to have such a high FT4 with a high TSH.

Did you drink coffee before the test?

Do you take a B Complex or Biotin, if so did you stop this 7 days before the test?

goofball profile image
goofball in reply to SeasideSusie

Last dose of Levo would be about 1.30 in the morning I would guess.

Don't think I had coffee, but not 100 % sure.

No only taking B12.

goofball profile image
goofball in reply to goofball

My T4 and TSH have always both been high

goofball profile image
goofball in reply to goofball

FT4-22.3

TSH-5.8 at last blood draw in February

SeasideSusie profile image
SeasideSusieRemembering in reply to goofball

goofball

We should leave 24 hours between last dose of Levo and blood draw, this is because we get a false high FT4 if we take it too close to the test. Taking last dose 24 hours before gives normal circulating amount of hormone.

Coffee can affect TSH.

When doing thyroid tests, we advise:

* Book the first appointment of the morning, or with private tests at home no later than 9am. This is because TSH is highest early morning and lowers throughout the day. If we are looking for a diagnosis of hypothyroidism, or looking for an increase in dose or to avoid a reduction then we need TSH to be as high as possible.

* Fast overnight - have your evening meal/supper as normal the night before but delay breakfast on the day of the test and drink water only until after the blood draw. Eating may lower TSH, caffeine containing drinks affect TSH.

* If taking thyroid hormone replacement, last dose of Levo should be 24 hours before blood draw, if taking NDT or T3 then last dose should be 8-12 hours before blood draw. Adjust timing the day before if necessary. This avoids measuring hormone levels at their peak after ingestion of hormone replacement. Take your thyroid meds after the blood draw. Taking your dose too close to the blood draw will give false high results, leaving any longer gap will give false low results.

* If you take Biotin or a B Complex containing Biotin (B7), leave this off for 7 days before any blood test. This is because if Biotin is used in the testing procedure it can give false results (most labs use biotin).

These are patient to patient tips which we don't discuss with doctors or phlebotomists.

I am taking Vitamin D, and supplimenting B12 as my last reading was 376 (180-914). My Ferritin and Folate are also near to the bottom of the range. I think that the TSH has lowered as previously it was 5.8, due to taking the B12. I have no recent results for Ferritin, B12, or Folate.

How much Vit D do you take and do you also take it's important cofactors - magnesium and Vit K2-MK7?

When taking Vit D supplement we should test twice a year to ensure we stay within the range recommended by the Vit D Council/Vit D Society - 100-150nmol/L. Too much Vit D will get stored and lead to toxicity, too little and it wont help raise or maintain your level.

Do you take anything for the low ferritin and folate?

When were your last vitamin tests done?

By the way, if you take B12 you should always take a B Complex as well, this keeps all the B vitamins in balance.

I don't think taking B12 will lower your TSH.

goofball profile image
goofball in reply to SeasideSusie

No take nothing for the Folate or Ferritin, also nothing with the B12. These vitamin tests done in February, for some reason no vitamin D results at this time. The last vitamin D result I have was 73.9 in April 2019.

Would you advise staying on the 75 dosage, and supplementing with Ferritin and Folate and B complex to go with the B12.?

goofball profile image
goofball in reply to goofball

Taking 25 Ug of vit D .

Thank you.

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

Getting vitamin D tested at least annually as minimum

£29 NHS postal kit

vitamindtest.org.uk

SeasideSusie profile image
SeasideSusieRemembering in reply to goofball

Goofball

Your Vit D test is too old, you really need to retest. Come back with new result.

Can't comment on Ferritin and Folate without up to date results/ranges. Ferritin is tricky because low Ferritin can suggest iron deficiency or iron deficiency anaemia, but it could just be low Ferritin without iron deficiency or anaemia. So when Ferritin is low it's a good idea to also do a full blood count and an iron panel.

Definitely need a B Complex when taking B12.

To be honest, I'd get all new tests for vitamins and base supplements on results.

Need to do thyroid test under advised conditions to get accurate results before come ting on whether dose needs changing.

goofball profile image
goofball in reply to SeasideSusie

I did have a full blood count in February, but it came back as normal, my Haemoglobin was -Haemoglobin concentration (Xa96v) 137 g/L [120 - 150], does this help?

Thank you for your advice.

SeasideSusie profile image
SeasideSusieRemembering in reply to goofball

goofball

Haemoglobin doesn't suggest anaemia, was there haematocrit, MCV, MCH, red blood cells?

An iron panel will tell you if you have iron deficiency.

goofball profile image
goofball in reply to SeasideSusie

Oh fair enough! it was the go to result that I actually understood from Biology. Yes there is this..Haematocrit- 0.4 (0.36-0.46),

Red Blood cells 4.08 (3.8-4.8)

Mean Cell Haemoglobin -34 pg -(27-32)

Mean Cell Volume 98fL (83-101)

None of this makes much sense to a minion of course!

Thank you so much :)

SeasideSusie profile image
SeasideSusieRemembering in reply to goofball

goofball

Slo there's nothing to suggest anaemia.

Exactly how low was your ferritin level when tested?

goofball profile image
goofball in reply to SeasideSusie

Well that's good, it was 33ng/ml (10-307), quite low.

SeasideSusie profile image
SeasideSusieRemembering in reply to goofball

goofball

So just 7.74% through range. I'd get an iron panel done to see if you have iron deficiency. Fast for 12 hours beforehand, water only to drink. No high iron foods or iron supplements in the week before the test.

goofball profile image
goofball in reply to SeasideSusie

Thank you

SlowDragon profile image
SlowDragonAdministrator

Last dose levothyroxine should be 24 hours before test

Blood tests should be as early as possible in morning before eating or drinking anything other than water

Are you on strictly gluten free diet?

Had coeliac blood test first?

goofball profile image
goofball in reply to SlowDragon

Tested negative for Coeliac, gave up being strictly gluten, it helped a bit or so I thought.

Blood test at 10.30 am, so not 24 hours.

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

According to Izabella Wentz the Thyroid Pharmacist approx 5% with Hashimoto's are coeliac, but over 80% find gluten free diet helps, sometimes significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

Trying gluten free diet for 3-6 months. If no noticeable improvement then reintroduce gluten and see if symptoms get worse

If you found gluten free diet reduced symptoms, then you need to stay on it

chriskresser.com/the-gluten...

amymyersmd.com/2018/04/3-re...

thyroidpharmacist.com/artic...

drknews.com/changing-your-d...

Non Coeliac Gluten sensitivity (NCGS) and autoimmune disease

ncbi.nlm.nih.gov/pubmed/296...

The predominance of Hashimoto thyroiditis represents an interesting finding, since it has been indirectly confirmed by an Italian study, showing that autoimmune thyroid disease is a risk factor for the evolution towards NCGS in a group of patients with minimal duodenal inflammation. On these bases, an autoimmune stigma in NCGS is strongly supported

ncbi.nlm.nih.gov/pubmed/300...

The obtained results suggest that the gluten-free diet may bring clinical benefits to women with autoimmune thyroid disease

nuclmed.gr/wp/wp-content/up...

In summary, whereas it is not yet clear whether a gluten free diet can prevent autoimmune diseases, it is worth mentioning that HT patients with or without CD benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned

restartmed.com/hashimotos-g...

Despite the fact that 5-10% of patients have Celiac disease, in my experience and in the experience of many other physicians, at least 80% + of patients with Hashimoto's who go gluten-free notice a reduction in their symptoms almost immediately.

Why gluten intolerance can upset cortisol levels

kalishinstitute.com/blog/gl...

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

Which is why Ft4 result is FALSE high

goofball profile image
goofball in reply to SlowDragon

Thank you. I am not sure that the gluten free diet worked totally for me, I had other problems that went un-diagnosed for several months, finally sorted now.

Would you advise staying on the 75 dosage, and supplementing with Ferritin and Folate and B complex to go with the B12.?

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

What vitamin supplements are you currently taking

What are actual results and ranges for

Folate, B12, vitamin D and ferritin

Your high TSH and very low Ft3 suggests GP is correct to increase dose to 100mcg

Always get same brand of levothyroxine

goofball profile image
goofball in reply to SlowDragon

I am taking vitamin D the 25ug, and B12 ( as suggested here a while ago).

These are my February 2020 results for Folate, Ferritin :-

Folate : 4.9ng/ml(3-20)

Ferritin :33ng/ml(10-307)

Vitamin D from April 2019

Vitamin D 73.7n/mol (50-150nmol/L as adequate vit D status.

Trouble is when she increased the dosage to 100mg from memory my T4 went up to 23. something, so she put me back on 75mg.

You don't mention the very low T3, an increase in Levo will not help this I take it, and assume that an increase in Folate and Ferritin could help ?

Thank you.

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

Yes increasing levothyroxine should help improve low Ft3

All levothyroxine is converted into Ft3

Optimal vitamin levels tends to improve conversion

Getting vitamin D tested essential

goofball profile image
goofball in reply to SlowDragon

Thank you

goofball profile image
goofball in reply to SlowDragon

Can I just check with you that increasing levothyroxine will help improve low Ft 3, is this still the case with Hashimoto's please?

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

Yes

Recommend you get vitamin D tests now

Or alternatively get FULL Thyroid and vitamin testing privately 6-8 weeks after increase in levothyroxine up to 100mcg dose

Trying absolutely strictly gluten free diet too

Ferritin low

Folate low

SlowDragon profile image
SlowDragonAdministrator in reply to goofball

Low ferritin

Eating iron rich foods like liver or liver pate once a week plus other red meat, pumpkin seeds and dark chocolate, plus daily orange juice or other vitamin C rich drink can help improve iron absorption

dailyiron.net

Links about iron and ferritin

irondisorders.org/Websites/...

drhedberg.com/ferritin-hypo...

This is interesting because I have noticed that many patients with Hashimoto’s disease and hypothyroidism, start to feel worse when their ferritin drops below 80 and usually there is hair loss when it drops below 50.

healthunlocked.com/thyroidu...

Thyroid disease is as much about optimising vitamins as fine tuning thyroid hormones

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