Front. Endocrinol., 29 August 2019 | doi.org/10.3389/fendo.2019....
Novel Insight Into the Epigenetic and Post-transcriptional Control of Cardiac Gene Expression by Thyroid Hormone
Francesca Forini, Giuseppina Nicolini, Letizia Pitto and Giorgio Iervasi*
This review is intensely complicated in that it discusses the interaction of T3 with genes that control cardiac function. I don't expect people to read it in full because it is very detailed in genetic analysis. But the summary is that T3 controls gene expression by promoting the altering of gene structure chemically so that they respond differently in different circumstances. Thereby a deficiency in T3 alters gene expression in disease (a phenomenon called epigenetics). This causes an increased likelihood of cardiac disease and failure. I merely put this out as a demonstration that the heart essentially needs adequate FT3 to operate properly, and the mechanisms for doing so. Obviously this knocks on to the essential need for adequate FT3 levels in blood to keep a healthy heart (and other things).