This recent paper indicates gluten-free diet can be a useful aid for women with Hashimoto's:
Exp Clin Endocrinol Diabetes 2019; 127(07): 417-422
DOI: 10.1055/a-0653-710
The Effect of Gluten-Free Diet on Thyroid Autoimmunity in Drug-Naïve Women with Hashimoto’s Thyroiditis: A Pilot Study
Robert Krysiak Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
Witold Szkróbka Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
Bogusław Okopień Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland
Abstract
Background Autoimmune thyroid disease is often accompanied by celiac disease.
Objective
The purpose of this study was to investigate whether a gluten-free diet affects thyroid autoimmunity, hypothalamic-pituitary-thyroid axis activity and thyroid function tests in women with Hashimoto’s thyroiditis and incidentally found positive anti-tissue transglutaminase antibodies.
Methods
The study included 34 women with autoimmune thyroiditis divided into two group. The patients belonging to the first one (group A, n=16) complied with the gluten-free diet for 6 months, while the remaining patients (group B, n=18) remained without any dietary treatment. Serum titers of thyroid peroxidase and thyroglobulin antibodies, as well as serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D were measured at the beginning of the study and 6 months later. Based on thyrotropin and free thyroid hormone levels, Jostel’s thyrotropin index, the SPINA-GT index and the SPINA-GD index were calculated.
Results
All patients completed the study protocol. In group B, serum thyrotropin and free thyroid hormones levels, serum 25-hydroxyvitamin D levels as well as the calculated indices remained at the similar levels. The gluten-free diet reduced thyroid antibody titers, as well as slightly increased 25-hydroxyvitamin D levels and the SPINA-GT index. In group A, the impact on TPOAb and TgAb titers correlated with the changes in the SPINA-GT index, whereas the impact on TPOAb with the changes in 25-hydroxyvitamin D levels.
Conclusions
The obtained results suggest that the gluten-free diet may bring clinical benefits to women with autoimmune thyroid disease.