While poking through the clinicaltrials.gov web site with "hypothyroidism" as the search criteria, I came across an interesting sounding study:
clinicaltrials.gov/ct2/show...
Study Description
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Brief Summary:
Hypothesis: Variations in the deiodinase 2 gene and monocarboxylate transporter 10 gene is associated with improvement in quality of life after initiation of combination therapy with L-Thyroxine and Liothyronine in patients with persistent hypothyroid symptoms despite conventional L-thyroxine mono-therapy.
Purpose: To re-test this hypothesis in patients with continued perceived effect of Liothyronine treatment at least one year after initiation in a patient population more representing of daily clinical practice. The study will help determine whether testing of specific gene variations might predict longtime effect of combination therapy.
Contacts
Contact: Christian Z Jensen, MD52652688 ext +45christian.zinck.jensen.01@regionh.dk
Sponsors and Collaborators
Birte Nygaard
Investigators
Principal Investigator:Birte Nygaard, Ph.D.Herlev Hospital
The time to investigate this is now, as the study has not yet started recruiting subjects.