The influence of thyroid disorders on bone density and biochemical markers of bone metabolism

[helvella]

Yes - far too few subjects.

data in the field of hypothyroidism (HT) are missing - And just who is to blame? It certainly doesn't appear to be members of TUK forum who have been talking about this for the best part of a decade.

There are two factors that could result in medics thinking that hypothyroidism does not affect bone density. First, a failure to understand and appreciate what hypothyroidism is and does. Second, jumping straight to an assumption without evidence to back it up.

Horm Mol Biol Clin Investig. 2018 Sep 15;35(1). pii: /j/hmbci.2018.35.issue-1/hmbci-2018-0039/hmbci-2018-0039.xml. doi: 10.1515/hmbci-2018-0039.

The influence of thyroid disorders on bone density and biochemical markers of bone metabolism.

Tsevis K1, Trakakis E1, Pergialiotis V2, Alhazidou E1, Peppa M3, Chrelias C1, Papantoniou N1, Panagopoulos P1.

Author information

1 Third Department of Obstetrics and Gynecology, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

2 Third Department of Obstetrics and Gynecology, University of Athens, Attikon University Hospital Athens Greece, Rimini 1 Chaidari, Athens, PC 12461, Greece, Phone: [phone], Fax: [phone].

3 Endocrine and Metabolic Bone Disorders Unit, 2nd Department of Internal Medicine and Research Institute and Diabetes Center, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Abstract

Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women.

Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital. A consecutive series of post-menopausal women was included, after excluding patients under hormone treatment (including levothyroxine supplementation) and those who received raloxifene, tamoxifen or tibolone during the study period as well as those who received treatment during the previous 12 months were excluded from the present study.

Results Overall, 188 women were included in the present study. Among them, 143 women had normal thyroid function, 32 women had hyperthyroidism and 13 women had HT. Correlation of thyroid function indices with osteoporosis indices revealed statistically significant correlations between thyroxine (T4) and free triiodothyronine (T3) with T-, Z-scores and BMD. Logistic regression analysis concerning the impact of HT and hyperthyroidism on T-score, Z-score and bone mass density revealed that both pathological entities negatively affect bone health (p < 0.05).

Conclusion The findings of our study suggest that not only hyperthyroidism, but also HT negatively affects BMD. Future studies should investigate this association and corroborate our findings.

KEYWORDS:

DEXA; bone mass density; hyperthyroidism; hypothyroidism

PMID: 30218603

DOI: 10.1515/hmbci-2018-0039

ncbi.nlm.nih.gov/pubmed/302...

[mrsm49]

Thanks for this i will take it to my next endo appt.

Ive always thought that being hypo is surely bad for bmd. I think my hypo years of going from bed to sofa with no exercise has got to be worse for my health than being on my current t3 combo, having a supressed tsh (t4,t3 in range) BUT at last being able to exercise again. They (endo) still like to put fear of god into me though, saying supressed tsh is going to lead to heart and bone probs, had me in tears at last appt. Surely a life of lying down would do that anyway!

[Marymary7]

Why is it so hard to treat and sort us out. My doc hasn't even acknowledged Hashimotos with a AntiTG above 500. I noticed my Inorganic Phosphate was flagged as very low and wondered if this was part of why I have Osteopenia. So little research being done and if we produce it the GP's ignore it.