High thyroglobulin antibody results: Can anyone... - Thyroid UK

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High thyroglobulin antibody results

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Can anyone advise me on my thyroid test results?

All results are within normal range apart from high Thyroglobin antibody which is at 620.000. (Normal range is 0 - 115.000)

I am feeling very unwell, throat is uncomfortable. I also have thyroid nodules, newly discovered.

Doctors tell mr results are irrelevant and nothing to do with me feelin ill.

Any advice appreciated please.

17 Replies

Just 'in-range' doesn't mean very much. It's where in the ranges the results fall that matters. So, best to give us the exact numbers - results and ranges.

But, it is possible that the antibodies themselves are causing symptoms. Although a doctor wouldn't know anything about that. They know very little about thyroid.

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Hidden in reply to greygoose

These are my thyroid function test results:

Thyroid S H. 0.854

Free thyroxine 14.40

Free T3. 4.61

Thyroglobulin Antibody 620.000

Thyroid peroxidase antibody. <9.0

Any advise, just feeling so ill for 2 months.

greygoose profile image
greygoose in reply to Hidden

Yes, but you didn't put the ranges, as I requested. Results without ranges are meaningless, because they vary from lab to lab.

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Hidden in reply to greygoose

Thank you greyroose

Thyroid S H. 0.854. Miu/L. 0.27 - 420

Free thyroxine 14.40. pmol/L 12 - 22

Free T3. 4.61. pmol/L3.10 - 680

Thyroglobulin Antibody 620.000. IU/ml 0.00 - 115.00

Thyroid peroxidase antibody. <9.0. IU/ml. 0 - 34.00

greygoose profile image
greygoose in reply to Hidden

Well, your results, at the moment, are euthyroid - although the FT4 is on the low side. But, as you have Hashi's, they are gong to jump around a bit. It's just a matter of luck if you manage to catch them when they're low. But, they are by no means irrelevant! Stupid man. The high antibodies say you have Hashi's.

How much do you know about Hashi's?

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Hidden in reply to greygoose

I’ve heard of it but know nothing at all really. I’ll do research. Thanks

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greygoose in reply to Hidden

Well, basically, this is it :

Hashi's is an autoimmune disease, where the immune system attacks and slowly destroys the thyroid.

After every attack, the dying cells release their stock of thyroid hormone into the blood stream, causing the levels of the Frees to shoot up - FT4 around 30 something, FT3 around 11/12 - and the TSH therefore drops to suppressed.

There is no knowing how long these high levels will persist, but eventually, they will drop by themselves as the excess hormone is used up or excreted, and not only will you become hypo again, but slightly more hypo than before, because there is now less thyroid to make hormone.

Therefore, it's very important that your doctor does not reduce your prescription, because you’re going to need it again! If you start to feel over-medicated at that point - some do, some don't - the best thing is to stop levo for a few days, then, when you feel hypo again, start taking it again. It's very important to know one's body, and how it reacts.

There is no cure for Hashi's - which is probably one of the reasons that doctors ignore it - apart from the fact that they know nothing about it, of course! But, there are things the patient can do for him/herself.

a) adopt a 100% gluten-free diet. Hashi's people are often sensitive to gluten, even if they don't have Coeliac disease, so stopping it can make them feel much better, and can often reduce the antibodies.

b) take selenium. This not only reduces antibodies, but can also help with conversion of T4 to T3 - something that Hashi's people often find difficult.

c) the best way to even out the swings from hypo to 'hyper' (often called Hashi's Flares, but that doesn't really sum up the way it works) is to keep the TSH suppressed. This is difficult because doctors are terrified by a suppressed TSH, for various false reasons, and because they don't understand the workings of Hashi's. But, TSH - Thyroid Stimulating Hormone (a pituitary hormone) - tries to stimulate the thyroid to make more hormone, but it also stimulates the immune system to attack. So, the less gland activity there is, the less immune system activity there will be, meaning less attacks, gland destruction slowed down and less swinging from hypo to hyper and back.

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Hidden in reply to greygoose

Thank you for that.

I just don’t know where to turn to for help. Doctor and ENT have both been dismissive of me, don’t seem to care how ill I am and that I’m unable to work.

Again, any advise? Will I need to go private to a thyroid specialist?

greygoose profile image
greygoose in reply to Hidden

No-one is going to diagnose you as hypo with that TSH. They're all too scared of losing their jobs to diagnose anyone with a TSH in range. And, as I said, there is not treatment for Hashi's. You can only do all the things I suggested above.

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Hidden in reply to greygoose

Thank you

greygoose profile image
greygoose in reply to Hidden

You're welcome. :)

SlowDragon profile image

Ask your GP to test your vitamin D, folate, ferritin and B12

These are often too low with Hashimoto's and improving with supplements is first step

Also very high TG antibodies can be linked to low B12


Come back with results and ranges once you have them

You can test privately if GP is unhelpful

Private tests are available. Thousands on here forced to do this as NHS often refuses to test FT3 or antibodies


Medichecks Thyroid plus ultra vitamin or Blue Horizon Thyroid plus eleven are the most popular choice. DIY finger prick test or option to pay extra for private blood draw. Both companies often have money off offers.

All thyroid tests should ideally be done as early as possible in morning and fasting. This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip, GP will be unaware)

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Hidden in reply to SlowDragon

Thank you


I'm in the same situation. All bloods ok....other than my thyroglobulin antibodies being 385 (0-115) my TSH is 3.59

I have strong hypo symptoms along with strong family history of it.

GP was useless. So saw a private Endo last night, who told me they are meaningless. He was a total waste of time and money.

I'm also feeling awful....with no help.

My basal temperature was 35° this moning. Very low.

Have you checked yours? This can be a sign of hypo.

Today I started taking a drop of iodine in a glass of water. I've read many experiences of how it can really help (despite what you may or may not of heard about iodine)

I suggest you read 'The Iodine Crisis' by Lynne Farrow.

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Hidden in reply to Kate_1984

Hi Kate

Since my last posts I’ve been to see an Endocrinologist privately.

He said the thyroglobulin antibodies are very important and going by my results from thyroid, blood tests and symptoms (feeling very unwell, chronic pain in thyroid gland, fatigue) he thinks my body and thyroid is being attacked by the Epstein-Barr Virus.

He sent be to a clinic in London for blood tests which will confirm, and gave me a CT scan.

Go next week for results.

He said I need Vit D, Folic Acid and vit B12

Started me on antiviral medication.

I will look into what you say about iodine - thank you.

I’ve found out that different doctors interpret results differently.

Please keep us posted

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I’m updating from my last post. My blood tests revealed that my thyroid has been attacked by the Epstein Barr Virus. This has caused nodules on my thyroid and also of thyroid pain.

My endocrinologist has put me on a 3 month course of antiviral medication.

I am very fatigued, feel generally unwell, anxiety and still have pain in my thyroid.

All started 3 months ago and don’t feel like I’m getting better.

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