Thought I’d share this.
"Interestingly enough, clinical and biological parameters observed at diagnosis in the subgroup of CH patients with tT4 and fT4 in the lowest quartile of the normal range were otherwise similar to those found in the patients with tT4 or fT4 below the normal range."
The subgroup refers to child-onset CH who had higher FT4 than adult-onset CH yet this did not signify difference in severity or symptomatology of the CH.
Is anyone diagnosed with hereditary central hypothyroidism? It’s been so difficult finding a doctor willing to work with me. I hit a wall with yet another doctor, who is referring me to a neurologist.
Here are my labs from a week and a half ago, on 112mcg Synthroid.
TSH 0.22 (0.32-5.04)
FT4 14.5 (10.6-19.7) 43% in range
FT3 4.01 (3.00-5.90) 35% in range
B12 518 (153-655)
Ferritin 91 (24-444)
Serum Iron 13.2 (10.6-33.8)
Vitamin D is good.
The difficulty has been with a firm diagnosis for hypothyroidism, I do not have Hashimotos (normal antibodies and ultrasound).
Here's the interesting part, my mother most recently and for the first time had a full thyroid function test.
TSH 2.28 (0.32-5.04)
FT4 12.5 (10.6-19.7) 21% in range
FT3 4.07 (3.00-5.90) 37% in range
TPOab 16 (<35) *my TPOab has been 11-18 over the years
Assuming my mother's TGab and ultrasound is also normal, we both have normal TSH with low-normal FT4/FT3.
1) A year and a half ago off of medication, my TSH was ~2.50 with FT4/FT3 at 31%/30%. I’ve noticed that nicotine artificially increases FT4 so my natural FT4 may be in the 20-25% of range rather than 30%.
2) Mother similarly has normal TSH with low-normal thyroid hormones.
The doctor is against increasing my dose. The improvement of and lingering of symptoms on Synthroid are downplayed, and the risk of hyperthyroidism over-exaggerated. Will be seeking an alternative opinion.