It is wise to make sure that you leave a good time interval (e.g. an hour or more) between taking your levothyroxine and any other medications or supplements.
It would be helpful if you explained what methylsulphonylmethane supplements are and why you want to take this.
I take MSM when my gut get irritated as it has excellent healing properties.
However, I would never take it with thyroid hormone replacement meds. Your Levo should be taken on an empty stomach with a glass of water, 1 hour before food and 2 -4 hours before supplements depending on which ones are being taken.
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