Thyroid UK
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Hypothyroid reduced Gfr raised creatinine hot flushes

I've been treated with thyroxine for nearly 6 mths on 75mcg mon to fri, 100mcg weekends not feeling great TSH was 3 now 8.8

Also have TPO antibodies at 550

Since being on thyroxine I have hot flushes a few in the day and a few through the night that wakes me up....

I has bloods and this showed reduced kidney function, raised creatinine and reduced egfr

Any advice is appreciated

Thank you

2 Replies


You are undermedicated to have TSH rise to 8.8 and your dose should be increased. The goal of Levothyroxine is to restore the patient to euthyroid status. For most patients that will be when TSH is 1.0 or lower with FT4 in the upper range. FT4 needs to be in the upper range in order that sufficient T3 is converted. Read Treatment Options in Email if you would like a copy of the Pulse article to show your GP.

Thyroid peroxidase antibodies are positive for autoimmune thyroid disease (Hashimoto's). There is no cure for Hashimoto's which causes 90% of hypothyroidism. Treatment is for the low thyroid levels it causes. Many people have found that 100% gluten-free diet is helpful in reducing Hashi flares, symptoms and eventually antibodies.

Kidney function can be reduced when thyroid levels are low so optimising your thyroid levels may also improve your kidney function.

Ask your GP to check whether the hot flushes are menopausal.


Isn't it a bit odd to have two different doses at various points in the week? I remember my gp once tried to make me split my 125mcg levo throughout the day and when I told my endo she just sort of looked at me like "what the hell is she doing" (to be fair, that was entirely justified). You're definitely undermedicated though, just wondered if the varied dosage happens regularly because I would have thought that it would cause more harm than good.


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