The idea reported here has been suggested many times - but this is the first time I have seen what is claimed to be clear, evidence.
Don't forget folks, thyroid is simple…
Gynecol Endocrinol. 2017 Mar 5:1-3. doi: 10.1080/09513590.2017.1296424. [Epub ahead of print]
Thyroid peroxidase identified in human granulosa cells: another piece to the thyroid-ovary puzzle?
Monteleone P1, Faviana P2, Artini PG3.
1 a Department of Obstetrics and Gynecology , USL Toscana Nordovest , Lucca , Italy.
2 b Pathology Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care, University of Pisa , Pisa , Italy , and.
3 c Department of Experimental and Clinical Medicine , Division of Gynecology and Obstetrics, University of Pisa , Pisa , Italy.
Thyroid hormones seemingly influence the maturation of the human oocyte. Thyroid hormone receptors have been isolated in granulosa mural and cumulus cells and the mature oocyte of the human ovarian follicle. Thyroid hormones are present in follicular fluid in concentrations similar to those in serum. Most importantly, enzymes involved in the chain that regulate the generation of thyroid hormones have been found in granulosa cells. For the first time, we have isolated thyroid peroxidase by immunocytochemistry in the granulosa cumulus cells of the human ovarian follicle, thereby supporting the hypothesis that the human ovarian follicle may be an independent thyroid-hormone producing unit.
Follicle development; granulosa cells; ovary; thyroid peroxidase