Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

This paper has imperfections (such as acknowledged issues with Free T3 testing). Nevertheless it does come to this conclusion:

... we found strong and highly significant inverse relationships between free hormones and spontaneous PTB in early and/or late pregnancy.

That is, low thyroid hormones meaning preterm birth is more likely.

I suspect few here would be surprised. Some degree of evidence as here has been very much needed.

Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth

Lauren E. Johns,

Kelly K. Ferguson,

Thomas F. McElrath,

Bhramar Mukherjee,

Ellen W. Seely,

John D. Meeker

PLOS

Published: January 6, 2017

dx.doi.org/10.1371/journal....

Abstract

Introduction

Overt thyroid disease in pregnancy is associated with numerous maternal and neonatal complications including preterm birth. Less is known about the contribution of trimester-specific subclinical alterations in individual thyroid hormones, especially in late gestation, on the risk of preterm birth. Herein, we examined the associations between subclinical changes in maternal thyroid hormone concentrations (TSH, total T3, free and total T4), measured at multiple time points in pregnancy, and the odds of preterm birth in pregnant women without clinical thyroid disease.

Participants and Methods

Data were obtained from pregnant women participating in a nested case-control study of preterm birth within on ongoing birth cohort study at Brigham and Women’s Hospital in Boston, MA (N = 439; 116 cases and 323 controls). We measured thyroid hormones in plasma collected at up to four time points in pregnancy (median = 10, 18, 26, and 35 weeks). We used multivariate logistic regression models stratified by study visit of sample collection to examine associations. To reveal potential biological pathways, we also explored these relationships by obstetric presentation of preterm birth (e.g., spontaneous preterm delivery) that have been previously hypothesized to share common underlying mechanisms.

Results

In samples collected at median 10 and 26 weeks of gestation, we found inverse associations between FT4 and the odds of overall preterm birth (odds ratio [OR] = 0.57, 95% confidence interval (CI) = 0.33, 1.00; and OR = 0.53, 95% CI = 0.34, 0.84, respectively). Positive associations were detected for total T3 at these same time points (OR = 2.52, 95% CI = 1.20, 5.31; and OR = 3.40, 95% CI = 1.56, 7.40, respectively). These effect estimates were stronger for spontaneous preterm birth.

Conclusions

Our results suggest that subclinical alterations in individual maternal thyroid hormones may influence the risk of preterm birth, and the strength of these associations vary by gestational age.

Full paper freely available here:

journals.plos.org/plosone/a...

I'll include a link to the PubMed entry for this paper because that helpfully has links to some related papers (at the right-hand side):

ncbi.nlm.nih.gov/pubmed/280...

4 Replies

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  • Thanks for that information Helvella very interesting. Some members wish to become pregnant, whilst others have difficulties and some more than one miscarriage.

    It's about time the Endocrinology Departments caught up on Research.

  • I find it shocking that 120 years after the first treatments for hypothyroidism were developed doctors are still so much in the dark about the importance of thyroid hormones in pregnancy, on both the mother and the child. This kind of research should have been done urgently as soon as blood testing became feasible.

  • Couldn't agree more.

    Realising that this thread might attract interest more generally with regard to pregnancy and thyroid, I looked back at previous posts I have put up. (No disrespect to others who have done so but my own were easy for me to find.)

    healthunlocked.com/thyroidu...

    healthunlocked.com/thyroidu...

    healthunlocked.com/thyroidu...

  • So sorry with what has happened but some great advice and info to show your GP. Please get you levels tested though not sure whether you should wait a while and your body settles down but now is the time to tell the GP where you want to go next and hopefully he is receptive. You can get private testing but the NHS should be doing this for you. We're youbslready under the care of a midwife? Maybe have a word with them and they may be able to arrange the test and/or give advise on the timing. Even if they just recommend the testing at least you can pass that onto the GP and ask him to put recent miscarriage on the lab forms as some labs won't do the extras without a valid reason.

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