Testosterone and levothyroxine: Does testosterone... - Thyroid UK

Thyroid UK

137,139 members160,824 posts

Testosterone and levothyroxine

Adam10 profile image
4 Replies

Does testosterone replacement therapy (TRT) interfere with levothyroxine?

I've had 9 months of TRT injections with the medication (Nebido). My TSH levels have risen from 0.5 (range 0.3-4.2 ulU/ml) to 1.7 then to 2.0. My fatigue and dull headache is back.

I donated blood yesterday due to high red blood count and high haemaglobin, under my Endo's guidance.

My Vitamins were tested and are all ok. Free T3 was 4.4 (2.8-6.8 pool/L range) and Free T4 was 15 (12-22) I read here that this is low

Is there a link between TRT and TSH levels?

I've been taking 100 mcg levo for 1-2 years. My Endo is adamant that 2.0 is ok and binned to increase. I've read her that TSH should be at or under 1.0. Should I add 25 mcg and take 125 mcg?

Could it be the colder weather necessitating a higher daily levo dose during the winter?

All connects gratefully received. Thank you in advance and for all your good work.

Written by
Adam10 profile image
Adam10
To view profiles and participate in discussions please or .
Read more about...
4 Replies
HIFL profile image
HIFL

Check your estradiol (E2) levels. When you take too much testosterone, it can convert to estradiol. Estradiol raises thyroid binding globulin (TBG), which then lowers your free thyroid levels. This should raise your TSH.

You are probably taking too much testosterone at once if you had to donate blood. This will lower your ferritin, which you need for thyroid hormone supplementation. While raising your levo could help somewhat, I think it would be easier to lower your TRT dose and to take less more often. Have you heard of subcutaneous dosing? Men are able to take much smaller doses that way twice a week, which greatly reduces their estradiol levels.

More on TRT and thyroid: tiredthyroid.com/mens-hormo...

scorpiojo profile image
scorpiojo in reply to HIFL

What is the best tests to have re testosterone etc when on t3 and t4 please? As I'm on hrt and identify with this some what, but haven't had a test re the hrt I'm taking, so no idea what my blood work is like or interaction witht3 or t4... Thanks Jo

HIFL profile image
HIFL in reply to scorpiojo

If you scroll down on this page, there's a comprehensive list of tests: tiredthyroid.com/what-labs....

scorpiojo profile image
scorpiojo in reply to HIFL

Thanks.. Didn't want to gatecrash but I haven't seen too many posts with the links with folk near menopause etc with thyroid issues... If you split the question and go to a menopause forum they don't know much re thyroid and vice versa... So thanks...

You may also like...

Testosterone tanked :(

Well I've finally got my blood results. Not very in depth at all .All my bloods from 2010 are on...

Testosterone deficiency

symptoms. Doctors and Endo seem to have left it all with me. The only thing the Endo could tell me...

High Testosterone Level

won't accept those but the Endo will. So the result came back with very high level of testosterone...

Cbd and levothyroxine

I gradually went from 150 mcg to 125 mcg then to 100 mcg but now on 115 mcg daily. I always go on...

Increased levothyroxine but felt worse. Back to usual dose but still so exhausted. Low iron and testosterone too. Would love advice please!

and tried 100mcg under care of endocrinologist, felt worse and no more energy, also TSH nearly...