I haven't posted for a while but wanted to update as you had all offered some really good advice to me over the last couple of years. After a long battle with my GP practice and several changes in GP I've finally been diagnosed as hypothryoid, within my latest blood tests it shows my TPO levels reduced from 257 in 2013 to 46 in the last month. Does this level of TPO still indicate hashimoto's? My TSH and Ft4 readings have always fluctuated dropping and raising every 3 months, although last two blood tests show that TSH has risen and FT4 has dropped. My GP has prescribed me with Levothryoxine 25mcg daily, with a view to increasing after 3 months, is this enough to combat the extreme fatigue, dry skin and lack of concentration that I currently have?