I have my Endo appointment on Tuesday. I have already had a curt letter to say they would not prescribe T3. I am not feeling very confident that i will get a very positive outcome but would like to give it my best shot so any guidance, papers, evidence on of how NDT /T3 does help many people would greatly help.
as i have posted before they want to reduce my levo again as my TSH is very low however i still have all hypo symptoms. Not feeling very mentally alert at the moment, have asked my husband to come with me but he wants all the facts and hard evidence to help fight my corner so anything he can read would also be a benefit.
Thank you all x
Written by
ju01749
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and excerpt - cursor to Page 80 and it's the first para:
Dose Selection in T3/T4 Study RCTs
The second logical basis for a conclusion
is the actions taken, i.e., the doses given to the
subjects. Most subjects received T3 below its
adult starting dose of 25 mcg/day.
The subjects in RCTs received T3 in some ratio to the
withdrawn T4. The various RCTs used T4:T3
ratios of 14:1, 10:1, and 5:1. Subsequent research by the US National Institutes of Health (NIH) found the therapeutic equivalence was
3:1.
Thus, most of the subjects were under
treated with the T3/T4 combination. In light
of the NIH finding, the conclusion that T3
therapy is never needed is invalid."
Your husband will find that it's only because of the BTA guidelines that they are reluctant to prescribe some T3.
He will also find they have never probably read research on it. They are unaware of clinical symptoms and only prescribe levothyroxine (and I read last week that that when Synthroid (the first levo I believe developed in the USA) was unapproved until around the year 2000.
And don't let them reduce your Levo on the strength of a suppressed TSH. Remind them that your FT4 was 12 and your FT3 was 4.5 - both in the lower half of their referemce ranges. Ask how you could possibly be overmedicated with those results being so low. I'd say you need an increase, not a decrease.
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