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Thyroid UK
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Newbie question!

Hi all, I have very recently been diagnosed with Hashi's. Have been on 50mg Levo for almost 3 weeks now. After about 11 days I started to feel like my old self again, so much better. However after 5 days of feeling better I then felt worse again - although not as bad as I did before the meds kicked in. Now back to feeling anxious, palpitations, chest pains, aches and general crappiness! Is it normal to be a bit up and down like this before everything settles?

5 Replies

Welcome to the forum, MrsCorlett.

It's not uncommon to feel well briefly and slump back and be a bit up and down for the first few weeks. It takes up to six weeks to feel the full impact of a dose and symptoms may linger a few weeks after you are optimally dosed.

You should have a follow up blood test six to eight weeks after starting Levothyroxine as you may need a dose increase. Leave 24 hours between last dose and blood draw which should be a fasting test (except water) early in the morning when TSH is highest. TSH falls after eating/drinking so fasting is helpful.

For maximum absorption take Levothyroxine on an empty stomach, 1 hour before, or 2 hours after food and drink, 2 hours away from other medication and supplements and, 4 hours away from iron, calcium, vitamin D and oestrogen.



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Thank you so much for your helpful reply! Really grateful for the advice, links and also advice re fasting etc before next blood test, which doctors didn't mention.

My doctor is very good but even so, and from what I have read online so far, people just seem to be left to hang a bit with this condition. So really appreciate the information.

Thank you 😀


yes its usual course

you are likely to need increasing doses but what is your




Vit d3

because they are all interleated and must be optimal ///////////NOT JUST in range

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Thank you v much for your reply! Good to know it's not just me as have been feeling a bit frustrated.

I am really really new to this and don't even know what my test levels of TSH etc were - thanks for mentioning the other things and I will get those looked into.



theres lots of info both on here and on thyroiduk.org

we have all been through the mill either personally or like me for husband ,daughter and 4 granddaughters only 1 of which is well on levothyroxine

the others have to take NDT

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