Even in the era of CH screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe CH

Another addition to the debunking of "Hypothyroidism is easy" trunkful of evidence.

I'd like to amend "adequate replacement treatment" to "adequate replacement treatment according to current medical practice". We surely have to wonder if enhanced treatment which, for example, more closely approximated to thyroid hormone levels in those of the controls would actually help? (Obviously, would some T3 improve matters? Or better control of dosing?)

Hear Res. 2015 May 15. pii: S0378-5955(15)00110-0. doi: 10.1016/j.heares.2015.04.018. [Epub ahead of print]

Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism.

Bruno R1, Aversa T2, Catena M3, Valenzise M4, Lombardo F5, De Luca F6, Wasniewska M7.

Author information

1Department of Otorhinolaryngology, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: rocco.bruno@unime.it.

2Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: tommaso.aversa@unime.it.

3Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: mariaausiliacatena@hotmail.com.

4Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: mariella.valenzise@unime.it.

5Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: fortunato.lombardo@unime.it.

6Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: filippo.deluca@unime.it.

7Department of Pediatrics, University of Messina, via Consolare Valeria, 98124 Messina, Italy. Electronic address: malgorzata.wasniewska@unime.it.

Abstract

Only few studies have focused on neurosensory hearing function of patients with congenital hypothyroidism (CH) identified by CH screening programs and treated early and, therefore, this issue remains still controversial. The aim of this study was to ascertain whether an early and adequate replacement treatment may be able to prevent sensorineural hearing loss in 32 screened children with CH and no associated risk factors for neuro-otologic alterations. These patients were recruited according to highly selective criteria aiming to preliminarily exclude the negative interference of both treatment variables and other underlying risk factors. All the selected patients underwent, at a median age of 15.4 years, an audiologic investigation, which evidenced a mild and subclinical hearing loss in 25% of them. The poorest hearing scores were recorded in the individuals with athyreosis and in those with absence of distal femur bony nucleus at CH diagnosis. The prevalence of hearing impairment was significantly higher in CH patients than in 32 age-matched control subjects with no CH (χ2 = 6.3, p < 0.025). In light of these findings, we concluded that: a) 25% of CH patients detected by CH screening may show, at a median age of 15.4 years, a mild and subclinical hearing impairment, despite early and adequate replacement treatment; b) the risk of hearing loss is higher in CH young patients than in age-matched control subjects without CH; c) the risk of hearing loss is closely associated with the severity of CH; d) this risk is particularly relevant in the children with pre-natal onset of hypothyroidism.

Copyright © 2015. Published by Elsevier B.V.

KEYWORDS:

athyreosis; bone maturation delay; distal femur nucleus; perceptive hearing impairment; prenatal thyroid failure; sensorineural hearing impairment

PMID:

25987501

[PubMed - as supplied by publisher]

ncbi.nlm.nih.gov/pubmed/259...

3 Replies

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  • Helvella, interesting. It reminds me I was having hearing difficulty years prior to becoming unwell and getting a Hashi diagnosis. I struggled to hear unless I could see the lips of the person speaking. This is no longer a problem. The benefit of optimal medication?

  • At my most hypo I seemed to be less able to cope with things were loud. As if I couldn't turn the volume down on my ears.

  • Other way around for me. When I became tired TV or radio volume went up. When I turned them on next day the volume was loud enough to hurt.

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