body odour changed? - check this out

[Mrs_Somerset]

Just posting this quickly as am already pooped / headache, but I was looking to see why my sweat had changed to something intolerable ( cabbages) and was all ready to blame the pain meds when I found this interesting article and now am persuing the methionine as a possible cause as it relates to my PA, but may relate to other illnesses.

Posting as others may not have realised this could be an issue, and just assuming they ate soemthing wierd - but if it continues for a few weeks - might be worth checking this out:

Odor originating from Metabolic Disorder

a. Trimethylaminuria

Trimethylaminuria also called fish odor syndrome or TMAU is a genetic disease. It is due to abnormal excretion of trimethylamine in the breath, urine, sweat, saliva and vaginal secretions. The odor produced is similar to decaying fish. The smell consists of sulfur compounds, plus nitrogen compounds (amines). The trimethylamine is made by bowel bacteria that break down certain amino acids, carnitine and choline that are in high concentrations in marine fish, egg yolks, certain beans and liver.

b. Maple Syrup Urine Disease

Maple syrup urine disease or MSUD refers to a rare inherited metabolic condition. The first form results from a deficient enzyme (branched-chain alpha-keto acid dehydrogenase, BCKD) necessary for the breakdown of the amino acids leucine, isoleucine, and valine. Without this enzyme, these amino acids build up to toxic levels in the body. If left untreated, this leads to brain damage and progressive nervous system degeneration in infants. Babies that suffer from the mild form have a sugary smell. Adults may have a burned sugar smell to urine. There second form responds well to the vitamin thiamine. It is reported that the patients smell like caramel, maple syrup or have a malty odor.

c. Phenylketunuria

Phenylketunuria or PKU is another inherited metabolic disorder. In this case the body cannot completely break down the protein phenylalanine because it lacks the enzyme phenylalanine hydroxylase. Because of this, phenylalanine builds up in the body’s cells and causes nervous system and brain damage. High levels of phenylalanine leads to increased levels of phenylketones in the blood which are excreted in the urine. The person may present a musty, mousy, wolflike, barny, horsey or stale smell.

d. Multiple Acyl-CoA Dehydrogenase Deficiency

Multiple acyl-CoA dehydrogenase deficiency (MADD) is an inherited fatty acid oxidation disorder (FOD). A person with MADD cannot efficiently breakdown fats and protein into energy. Once the body uses up its first source of energy, blood sugar (glucose), the body becomes weaker because it cannot then make energy from fats. Therefore, people with this disorder must eat on a very regular basis and should not go long without food. The person presents variable body odor of sweaty feet.

e. Isovaleric Acidaemia

Isovaleric acidaemia is a rare genetic condition in which the body is unable to process certain proteins properly. People with this disorder have abnormal levels of an enzyme that helps break down the amino acid leucine, a building block of proteins. It is related to the genetic metabolic disorder Maple syrup syndrome. A symptom of isovaleric acidemia is a odor of cheesy, acrid,sweaty feet. This odor is result of the buildup of isovaleric acid compound.

f. Tyrosinaemia

Tyrosinaemia is an error of metabolism, inherited, in which the body can not effectively break down the amino acid tyrosine, found in most animal and plant proteins. It is an autosomal recessive, that means two copies of an abnormal gene must be present in order for this to develop. There are three types of tyrosinemia, each with distinctive symptoms and caused by the deficiency of a different enzyme. One of the symptoms of Tyrodinaemia type 1 is a odor like cabbage or rancid butter.

g. Diabetes Mellitus

Diabetes Mellitus. Almost all of the food we eat is broken down into glucose (sugar in the blood). Glucose is the main source of fuel for the body and is used by cells for growth and energy. Glucose needs insulin to get into cells. Insulin is a hormone made by the pancreas. In individuals with diabetes, the pancreas may create little or no insulin, or the cells do not react appropriately to the insulin that is produced. Glucose builds up in the blood, and is excreted in the urine. So the body loses its primary source of fuel. Fruity breath is present in people with diabetes.

h. Diabetic Ketoacidosis

Diabetic ketoacidosis. When the level of the blood sugar gets too high, the body creates "ketones" as a by-product of fat digestion. These ketones create blood acidity which causes "acidosis" of the blood. At the same time, the kidneys excrete large amounts of glucose-rich urine, causing dehydration. The patient may have a fruity breath, a sweet taste on the skin, or emanate a distinctive, chemical smell.

i. 3-Methylcrotonylglycinuria

3-Methylcrotonylglycinuria, multiple carboxylase deficiency or 3MCC is another autosomal recessive genetic trait means that this faulty gene usually appears when two carriers have children together and pass it to their offspring. In this case the body is unable to process certain proteins properly. Patients have abnormal levels of an enzyme that helps break down proteins containing the building block (amino acid) called leucine. As a carboxylase enzyme, 3-MCC requires biotin for activity. There are four carboxylases in humans that use biotin and each can be deficient singly or together. If biotin metabolism is defective, functions of all four carboxylases will be low, resulting in Multiple Carboxylase Deficiency. MCC is predominantly located in the inner membrane of the mitochondria. The patient presents an odor like male cat urine.

j. Cystinuria

Cystinuria is an inherited, metabolic disorder. It is characterized by the accumulation of cystine crystals (uroliths, caculi or stones) in the kidneys, ureter and bladder. People with cystinuria cannot properly reabsorb cystine into their bloodstream during the filtering process in the kidneys. Cystine is a amino acid, a building block of proteins. Most of the time, this excess cystine is simply excreted in the urine. But in some cases the cystine cannot stay dissolved and forms crystals. Because cystine is one of the sulfur-containing amino acids, the urine may have a characteristic "rotten egg" odor.

k. Hypermethioninemia

Hypermethioninemia this condition can happen when methionine (amino acid) is not metabolized correctly in the body. Individuals with this condition may experience a fishy, sweety and fruity, rancid butter or boiled cabbage odor. It has been said that tyrosinosis-tyrosinemia is the same as hypermethioninemia.

l. Oast-House Syndrome

Oast-house syndrome also called Smith-Strang diesease is an inherited disease (autosomal recessive) due to malabsorption of methionine and secondary malabsorption of other amino acids. Part of the unabsorbed methionine is converted by colonic bacteria to a-hydroxybutyric acid. The urine has an odor similar to that of dried celery, yeast or malt, or an oasthouse (a building for drying hops). The patients have white hair, mental retardation among other symptoms.

m. Congenital Adrenal Hyperplasia

Congenital adrenal hyperplasia – CAH is a group of inherited disorders which causes an enzyme deficiency (most commonly 21-hydroxylase) resulting in the inability of the adrenal glands to make hormones: cortisol and/or aldosterone. Since the body can't make enough cortisol (and in some cases aldosterone), it stimulates the production of other adrenal hormones that are called androgens. Three main forms of Congenital Adrenal Hyperplasia (CAH) exist: the severe salt-wasting, non-salt wasting forms, and a milder form. The non classical or milder form of CAH can produce body odor during childhood because of the premature puberty.

Big Hugs

M

P.s. check all ideas and treatments with your healthcare provider before proceeding with a new regime

[Heloise]

That was very interesting, Mrs. It explains why no amount of hygiene can help even though that is the accusation.

[gillykins2 in reply to Heloise]

Heloise,

When taking Levothyroxine, I used to be able to smell my body odour when drying myself after my daily shower! When I went onto NDT body odour stopped.

[Heloise in reply to gillykins2]

That must have been a relief. I do wonder how replacement hormone behaves in the cells. I think T3 has preferences, similar to how the body uses elements like glucose which will go to the brain and leave other areas if short on supply. So much we may never know.

[gillykins2 in reply to Heloise]

Yes, a relief, it's not comfortable being around other people, if you know you smell unpleasant.

That's an interesting idea re. T3. Could that explain, in part, the variety of symptoms - muscle aches this week, stomach cramps next?

[Heloise in reply to gillykins2]

This information comes from the National Academy of Hypothyroidism:

Individual variations in deiodinase

The relative amounts of D1, D2, and D3 vary in different tissues among different individuals (284) and under varying conditions (8,11,12-21,23-26,28-45,100-103,116-120,126-129,146,174-176,216,224,229,), resulting in hundreds of possible symptoms with hypothyroidism; some people have one symptom, some have a few, and some people have many, depending on the relative level of T3 in each tissue. Unfortunately, serum thyroid levels often do not accurately reflect intracellular tissue levels or levels in a particular tissue.

nahypothyroidism.org/deiodi...

Also, it looks like the pituitary steals more T3.

Due to a unique make-up of deiodinases in the pituitary, it will respond differently and often opposite to that of every other tissue in the body. Numerous conditions result in an increase in pituitary T3 levels while simultaneously suppressing cellular T3 levels in the rest of the body, making the pituitary, and thus the TSH, a poor indicator for tissue thyroid levels in the rest of the body under numerous physiologic conditions.

Read also about the transport of T3.

[Oliu in reply to gillykins2]

I am sorry,what is NDT?

[helvella Administrator Thyroid UK in reply to Oliu]

You might find my list of abbreviations and acronyms of some use:

dropbox.com/s/og3lmxa1dqadb...

NDT = natural desiccated thyroid - which is made from animal thyroids. The official products are all porcine but some over-the-counter products are bovine.

[gillykins2]

Mrs Somerset,

Your post reminded me of something I read, or heard, a while back - that people are attracted to people with similar health issues. My husband had M.E. My oldest friends has Fibromyalgia.

Could it be to do with body odour, as much as physical attraction?

My first husband had ulcerative colitis. I always knew when he was having an attack, because his body odour changed. It wasn't nasty, I just didn't find it comfortable. Whereas, with my second husband, we often asked each other about body odour, but didn't notice any unpleasant change.