Thyroid UK
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UK Trial, Thyroid Hormone Replacement for Subclinical Hypothyroidism

This Trial is now recruiting and taking place in Glasgow. Unfortunately, If you wish to join, you must discuss this with your own doctor who may decide to get in touch with the contact listed at the end of the information.

The trial is run by the NHS National Institute for Health Research.

Just thought that this may be of use for those living in the area, having a diagnosis of Subclinical Hypothyroidism and struggling to get prescribed any thyroid medication.


3 Replies

Is this the one you were referring to?


Subclinical hypothyroidism (SCH) is a common condition (818%) among older men and women. Although by definition SCH comprises biochemically mild thyroid hormone deficiency without overt symptoms, it is a possible contributor to multiple problems in older age. Thyroid hormone has effects on numerous physiological systems, including the vascular tree, heart, skeletal muscle and brain. Therefore, thyroxine substitution to overcome thyroid hormone deficiency has the potential to give multisystem benefits to older people with SCH.

Small studies have reported reduced atherosclerosis and improved heart function with thyroxine replacement, but no large clinical trials have been performed. Therefore the available evidence is limited, leading to major variations in guidelines and clinical practice, with uncertainty regarding the indications for screening and treatment. The investigators propose a multicentre randomised placebo controlled trial to assess the impact of thyroxine replacement in 3,000 older adults with persisting SCH (excluding those in whom it is a temporary phenomenon who are unlikely to benefit). The investigators will include older men and women with a wide age range and of varying health status. Outcomes include cardiovascular events, health related quality of life, muscle strength and executive cognitive function over 3 years of follow up. Blood and urine samples will be stored in a biobank, to allow future research on causes of ill health in older people with SCH.

The investigators have the support of patient advocacy groups and a consortium with the wide range of expertise and experience required to conduct large scale multicentre clinical trials. The proposal explores the multisystem and quality of life benefits to older people of a tailored approach to management of SCH.

This clinical trial should definitively clarify whether thyroxine treatment for SCH provides benefits that are relevant for patients. This trial will provide strong evidence with the potential to improve clinical practice, reduce health care costs and promote healthy ageing of older adults.



Hi Rod - Thanks so much for checking my post, forgot to put in the link.

Yes, your link points to the same trial. I checked where I found the info in the first place and it is via this link;

I just put thyroid in the search, there are a number of trials that come up so just meant to post about the sub clinical one which is this link;

I think that your link gives a better understanding of the trial and includes more information so probably a better link to use in the post.

Thanks again - Maddie


Very encouraging. Thanks for posting.


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