Thyroid UK
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Hi all, I'm seeing an endo on Thursday as I have lots of health issues that MY GP's don't quite understand. I have a very elevated SHBG level. My GP thought I had thyroid problems but has said my blood test rules that out, which he was surprised about.

Does anyone know anything about high SHBG? I know it can be caused by hyperthyroidism, and that it might bind thyroid hormones?

Any insight greatly appreciated. I am a 21 year old woman and I've been ill with vague but steadily worsening symptoms for over 4 years now and desperate for some answers. I'd like to see my Endo with as much knowledge as possible! Thank you xxx

2 Replies

Hi, what is SHGB and it would also help if you could get your blood results and post them on here for people to comment on. Ask your doctor for a copy of your bloods with reference ranges or ask the receptionist if she could print them off. It is your right to have these results. x


A bit of info for you that might help you or your GP

SHBG has both enhancing and inhibiting hormonal influences. It decreases with high levels of insulin, growth hormone, insulin-like growth factor 1 (IGF-1), androgens, prolactin and transcortin. High estrogen, and thyroxine cause it to increase.

As another example anti-psoriatic drugs that inhibit TNF-alpha cause an increase in SHBG. The common downstream mechanism for all of these, including the effect of thyroid hormones[12] was downregulation of a whole group of regulating proteins

Blood values[edit]

Reference ranges for blood tests for SHBG have been estimated to be:

Patient typeRange

Adult female, premenopausal40 - 120 nmol/L

Adult female, postmenopausal28 - 112 nmol/L

Adult male20 - 60 nmol/L

Age 1 - 23 months60 - 252 nmol/L

Prepubertal (24m - 8y)72 - 220 nmol/L

Pubertal female36 - 125 nmol/L

Pubertal male16 - 100 nmol/L


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