Thyroid UK

Myxedema won't go away!


I have Hashimoto's and have been on a wide range of compounded NDT dosages (1 grain to 6 grains) for the last two years and yet my myxedema (mucin-like deposits under the skin) seems to be getting worse. I have the full-moon round face and can't pinch any skin ANYWHERE on my body. I've gained an easy 15 pounds and nothing seems to be working to get it off.

I'm on a ton of supplements (both vitamins and herbs), Lugol's Iodine, as well as LDN and just recently, my doctor added a small dose of T3 only to my current dose of NDT. Has anyone else out there suffered from full-body myxedema? If so, what did you find that finally worked to make it go away? I'm at my wits end and can't stand not looking like myself any longer!

4 Replies

I am sorry you are suffering badly with Myxedema. I shall post a couple of links which may be helpful, I hope. This is an excerpt from the first one:

The problem with this scenario is that most of the time, the mitochondria in toxic and defective cells are unable to convey to the brain their need for thyroid hormone, even if it's urgently required. In fact, according to numerous studies, people whose mitochondria tested abnormal nonetheless had normal thyroid hormone levels in their blood. Modern thyroid blood tests, Starr reminds us, do not detect Type 2 hypothyroidism "because thyroid hormone levels [in the bloodstream] may be normal, but they are not high enough to stimulate the . . . defective mitochondria into normal activity" [emphasis added]. Nor are the blood thyroid hormone levels high enough to induce the resistant receptor sites on the cells to start accepting hormone. Any part of the cell can be involved in the failure to process and utilize thyroid hormone. "There is no scientific evidence," Starr bluntly states, after providing a detailed review of the literature, "to support the doctors' claim that the TSH test detects hypothyroidism in the vast majority of patients. The validity of the TSH [tests] has been [solely] established by word of mouth and [only] purportedly by the [flawed] studies I have presented." Unfortunately, few medical personnel appear to have read the literature upon which the presumed validity of the TSH test was based – or have read it with a careful enough analytic eye.


Read from the second question onwards:-

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Wow! Thanks so much for these very insightful articles. So, if I'm understanding correctly, there's a good chance that I have some degree of tissue resistance to thyroid hormone? Since my doctor added pure T3 to my current dose of NDT, then I should keep slowly increasing the T3 dosage until eventually my myxedema goes away? Does this sound like I'm on the right track? Thanks again for all of your help! :)


It sounds fine too me. You have to keep a record of your pulse and temp, so that if you take a little too much, you reduce slightly. As you will have read, some need to take higher doses than normal to become 'normal'. Bearing in mind I am not qualified in any way. I have just read up on some things.

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Just curious if the myxedema has shifted any? I'm going through the same thing now.


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