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Long-Term Exposure to Excessive Iodine from Water Is Associated with Thyroid Dysfunction in Children

Long-Term Exposure to Excessive Iodine from Water Is Associated with Thyroid Dysfunction in Children

The amounts of iodine in water discussed below are indeed high. The bottom of the range they call high is a typical recommended daily intake for an adult in each litre of water - 150 micrograms per litre.

Nonetheless, with some of the high-dose iodine supplements, people could be taking 12500 micrograms a day.

J Nutr. 2013 Oct 9. [Epub ahead of print]

Long-Term Exposure to Excessive Iodine from Water Is Associated with Thyroid Dysfunction in Children.

Sang Z, Chen W, Shen J, Tan L, Zhao N, Liu H, Wen S, Wei W, Zhang G, Zhang W.


Department of Nutrition and Food Science, and.


Previous studies have indicated an association between iodine excess and increased incidence of thyroid dysfunction in adults. However, there have been few studies on how the intake of excessive iodine affects thyroid function in children. The objective of this study was to assess the effects of a long-term exposure to excessive iodine on thyroid dysfunction in children. Urinary iodine concentration (UIC) and thyroid function in 371 children from a high iodine (HI) area (water iodine: 150-963 μg/L) and 150 children from an adequate iodine (AI) area (water iodine: 12.8-50.9 μg/L) were measured. The water iodine concentration in the HI area was higher than that in the AI area (P < 0.001) and the median urinary iodine concentration of children in the HI area was 1030 μg/L, which was 8.6 times than that of children in the AI area (123 μg/L) (P < 0.001). Children in the HI area had a higher concentration of sensitive thyroid stimulating hormone and higher positivity of both thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb). The prevalence of thyroid diseases was higher in HI area children than that in AI area children (P = 0.000), especially subclinical hypothyroidism (SCH) (P = 0.004). A body mass index (BMI) of ≥22.3 kg/m2 was associated with the incidence of SCH (OR: 5.51; 95% CI: 1.52, 19.9; P = 0.009). UIC ≥600 μg/L (OR: 3.62; 95% CI: 1.22, 10.8; P = 0.024) and TPOAb or TGAb-positivity (Ab+) (OR: 6.48; 95% CI: 1.78, 23.6; P = 0.005) in children were significantly and independently associated with SCH. Interactions between UIC ≥800 μg/L and Ab+ (P-interaction = 0.004) were found. Furthermore, increased thyroid volume was correlated with higher UIC (β = 0.22; P = 0.002). Excessive iodine intake in children in HI areas is associated with impaired thyroid function; UIC ≥600 μg/L and Ab+ are the risk factors for SCH. Effective measures are needed to be taken for reducing excessive iodine intake.



[PubMed - as supplied by publisher]

Please note that on that page, on the right-hand side, are links to other related papers. They may take the same or differing views on the subject. Quite clearly the above is not the last word.


Image: 1kg cylinder of iodine produced by heating in water under pressure: Author Greenhorn1

2 Replies

Very interesting article, Rod, and a fascinating image! Where do you find these things!


Some of my images come from here:

They have a huge number of images which are available for pretty much unrestricted use. Often only the attribution being required.


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