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Xofigo
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What next after Docetaxel...?
Xofigo
was ruled out based on my previous experience with Lu 177 and actual weak lab data. I elected to take a chance with Xtandi, probable another short term failure.
Xofigo
was ruled out based on my previous experience with Lu 177 and actual weak lab data. I elected to take a chance with Xtandi, probable another short term failure.
Ollie1948
in
Advanced Prostate Cancer
10 months ago
Xofigo+Xtandi beats Xtandi alone for mCRPC
Compared to Xtandi alone,
Xofigo
+Xtandi: • improved radiographic progression-free survival by 31% • improved overall survival by 31% These were men who had predominantly bone metastases and all received a bone strengthening agent (Zometa or Xgeva). They may have received Zytiga previously.
Compared to Xtandi alone,
Xofigo
+Xtandi: • improved radiographic progression-free survival by 31% • improved overall survival by 31% These were men who had predominantly bone metastases and all received a bone strengthening agent (Zometa or Xgeva). They may have received Zytiga previously.
Tall_Allen
in
Advanced Prostate Cancer
12 days ago
Treatment after Lu /Pluvicto?
Also, I understand that
Xofigo
yields better benefits at this stage (low volume) but they are advising against. I'm also wondering about Actinium as his tumors are PSMA avid. Thanks for anyone with experience to share!
Also, I understand that
Xofigo
yields better benefits at this stage (low volume) but they are advising against. I'm also wondering about Actinium as his tumors are PSMA avid. Thanks for anyone with experience to share!
cancervictim
in
Advanced Prostate Cancer
11 months ago
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Anyone w Xofigo experience?
RO recommending
Xofigo
. Can you please share your experience on this treatment and whether you modified your ADT during the 20 weeks ? Did you have any side effects? What was the outcome +12 mos?Thanks gents and keep up the fight !!!💪
RO recommending
Xofigo
. Can you please share your experience on this treatment and whether you modified your ADT during the 20 weeks ? Did you have any side effects? What was the outcome +12 mos?Thanks gents and keep up the fight !!!💪
JDN0415
in
Advanced Prostate Cancer
1 year ago
PSADT question...plus Xofigo and comorbidities
I am waiting to be placed on
Xofigo
. Should I be panicking about this PSADT? Also most folks seem to be otherwise healthy.....do any of you guys have comorbidities? I am a renal patient on hemodialysis and I have a pacemaker that prevents me from having MRIs.
I am waiting to be placed on
Xofigo
. Should I be panicking about this PSADT? Also most folks seem to be otherwise healthy.....do any of you guys have comorbidities? I am a renal patient on hemodialysis and I have a pacemaker that prevents me from having MRIs.
WeatherLook
in
Advanced Prostate Cancer
1 year ago
Chemo Update March 27, 2024
I have been CRPC since 2022 and have tried abiraterone and Radium 223 (
Xofigo
). I just completed 7 rounds of docetaxel again and PSA went from 105 to 3.1 after 4 rounds then started doubling. Now I will be switching to cabazitaxel for another 6 to 10 rounds. Has anyone switched and had any luck?
I have been CRPC since 2022 and have tried abiraterone and Radium 223 (
Xofigo
). I just completed 7 rounds of docetaxel again and PSA went from 105 to 3.1 after 4 rounds then started doubling. Now I will be switching to cabazitaxel for another 6 to 10 rounds. Has anyone switched and had any luck?
Islandboy2021
in
Advanced Prostate Cancer
6 months ago
Ra 223 (Xofigo) after Lu 177 (Pluvicto) anyone?
Our MO is questioning the efficacy of Ra 223 as next step after Lu and Docetaxel. All hubby's biomarkers suggest he can complete Ra 223 and benefit from it. MO cites the cost of Ra and the lack of evidence regarding the efficacy of Ra after Lu as justification to go to Cabizataxel as next treatment
Our MO is questioning the efficacy of Ra 223 as next step after Lu and Docetaxel. All hubby's biomarkers suggest he can complete Ra 223 and benefit from it. MO cites the cost of Ra and the lack of evidence regarding the efficacy of Ra after Lu as justification to go to Cabizataxel as next treatment
cancervictim
in
Advanced Prostate Cancer
4 months ago
Decision Time Very Soon
SOC could be
Xofigo
(as all mets in bone) or Pluvicto or cabazataxel. A concern about all those is that my white count took almost 5 mo. to come back to normal after my final chemo, despite Neulasta. There's Provenge, which maybe could help T cells to get thru to the cancer cells??
SOC could be
Xofigo
(as all mets in bone) or Pluvicto or cabazataxel. A concern about all those is that my white count took almost 5 mo. to come back to normal after my final chemo, despite Neulasta. There's Provenge, which maybe could help T cells to get thru to the cancer cells??
rsgdmd
in
Advanced Prostate Cancer
1 year ago
Seeking options/opinions
MO suggested going to
Xofigo
but hemoglobin numbers were too low, sub 7, got transfusion. Decided to rechallenge with taxotere. (Zytiga worked fir about year, Xtandi for month before trying Pluvicto). I managed one taxotere, psa stopped going up, now at 620 after.
MO suggested going to
Xofigo
but hemoglobin numbers were too low, sub 7, got transfusion. Decided to rechallenge with taxotere. (Zytiga worked fir about year, Xtandi for month before trying Pluvicto). I managed one taxotere, psa stopped going up, now at 620 after.
RunThru
in
Advanced Prostate Cancer
1 year ago
Our Pluvicto story
We haven't tried
xofigo
yet. Our MO feels that my husband needs to recover from Pluvicto before trying
xofigo
. Darolutamide and apalutamide were discussed but insurance denied both. My husband didn't have success with Xtandi or Zytiga. MO feels that cabitaxel is our next best step.
We haven't tried
xofigo
yet. Our MO feels that my husband needs to recover from Pluvicto before trying
xofigo
. Darolutamide and apalutamide were discussed but insurance denied both. My husband didn't have success with Xtandi or Zytiga. MO feels that cabitaxel is our next best step.
Yadifan
in
Advanced Prostate Cancer
1 year ago
8/4/23 Update questions for MO
Choose from and possibly combine: Taxotere, Xtandi,
Xofigo
, and Provenge. 4. Switch to xtandi or Casodex 5. Try docetaxel, which works by directly killing cancer cells, but can have substantial side effects, 6.
Choose from and possibly combine: Taxotere, Xtandi,
Xofigo
, and Provenge. 4. Switch to xtandi or Casodex 5. Try docetaxel, which works by directly killing cancer cells, but can have substantial side effects, 6.
alperk
in
Advanced Prostate Cancer
1 year ago
Xofigo Update
Now that is no longer working and have completed 5 of 6 treatments of
Xofigo
- which he is tolerating well (blood counts are holding up, with only minor indigestion/diarrhea. The most likely next step as things progress will be chemo (docetaxel).
Now that is no longer working and have completed 5 of 6 treatments of
Xofigo
- which he is tolerating well (blood counts are holding up, with only minor indigestion/diarrhea. The most likely next step as things progress will be chemo (docetaxel).
Tinuriel
in
Advanced Prostate Cancer
1 year ago
A List for Newly Diagnosed that My Wife did in 2022 please add to list if anything is missed or wrong or needs updating. TIA
/ dissection: *Pelvic lymph node dissection (PLND) *Extended Lymph Node Dissection (EPLD) *Radiation and Radiopharmaceuticals: *Radionuclide such as Actinium-225 is an alpha-emitting radionuclide * Radiation therapy, SBRT, EBRT, brachytherapy/seeding * Radio-pharmaceuticals such as Pluvicto,
Xofigo
/ dissection: *Pelvic lymph node dissection (PLND) *Extended Lymph Node Dissection (EPLD) *Radiation and Radiopharmaceuticals: *Radionuclide such as Actinium-225 is an alpha-emitting radionuclide * Radiation therapy, SBRT, EBRT, brachytherapy/seeding * Radio-pharmaceuticals such as Pluvicto,
Xofigo
Shorehousejam
in
Advanced Prostate Cancer
1 year ago
experience with pain from bone mets
He is now on Cabo,
Xofigo
(R223) and soon to get Keytruda. We are hoping this line of treatment can ease the pain from bone mets which make it hard to even walk. The pain meds can only go so far and have harsh side effects. Any relevant experience or encouraging stories?
He is now on Cabo,
Xofigo
(R223) and soon to get Keytruda. We are hoping this line of treatment can ease the pain from bone mets which make it hard to even walk. The pain meds can only go so far and have harsh side effects. Any relevant experience or encouraging stories?
Chris_Ali
in
Advanced Prostate Cancer
10 months ago
Hurdle
MO had me scheduled to start
xofigo
3 weeks ago but hemoglobin dropped to 6.7 so transfusion instead. He now what's to rechallenge with taxotere starting tomorrow. I had hemoglobin tested two weeks ago and it was 7.5. But tested again yesterday and was at 6.9 so another transfusion.
MO had me scheduled to start
xofigo
3 weeks ago but hemoglobin dropped to 6.7 so transfusion instead. He now what's to rechallenge with taxotere starting tomorrow. I had hemoglobin tested two weeks ago and it was 7.5. But tested again yesterday and was at 6.9 so another transfusion.
RunThru
in
Advanced Prostate Cancer
1 year ago
Radium 223 Xofigo Treatment
I have considerable pain in my hips and tale bone 3 days after first injection of
Xofigo
. The Radiologists mentioned I could get pain flare a few days after the injection. Is there anyone familiar with Radium 223 side effects.
I have considerable pain in my hips and tale bone 3 days after first injection of
Xofigo
. The Radiologists mentioned I could get pain flare a few days after the injection. Is there anyone familiar with Radium 223 side effects.
Islandboy2021
in
Advanced Prostate Cancer
1 year ago
Pluvicto works but at what cost
Previously on Firmagon, Xtandi worked for awhile, nothing with
Xofigo
and a few rounds of Jevtana didn’t help and caused problems, also had localized XRT - but had to have chemo to qualify for Pluvicto which is a great advanced treatment for many of us After multiple delays getting Pluvicto with PSA
Previously on Firmagon, Xtandi worked for awhile, nothing with
Xofigo
and a few rounds of Jevtana didn’t help and caused problems, also had localized XRT - but had to have chemo to qualify for Pluvicto which is a great advanced treatment for many of us After multiple delays getting Pluvicto with PSA
Beach18
in
Advanced Prostate Cancer
1 year ago
Updated treatment plan for progressing MCRPC
Xgeva every 3 months,
Xofigo
every month for 6 months and possibly add enzalutamide. What do you think of this plan, Thanks,
Xgeva every 3 months,
Xofigo
every month for 6 months and possibly add enzalutamide. What do you think of this plan, Thanks,
Islandboy2021
in
Advanced Prostate Cancer
1 year ago
Almost scheduled for Lutium...
My husband Rudy had a consultation for
Xofigo
this past Wednesday at the VA San Diego but it was canceled and UCSD sceduled a consultation for Lutium. They said they would be sending us a schedule treatments soon with the first treatment of June. Feeling cautiously optimistic.. and grateful.
My husband Rudy had a consultation for
Xofigo
this past Wednesday at the VA San Diego but it was canceled and UCSD sceduled a consultation for Lutium. They said they would be sending us a schedule treatments soon with the first treatment of June. Feeling cautiously optimistic.. and grateful.
Karirudy
in
Advanced Prostate Cancer
1 year ago
Where to go after Lutetium 177?
As we understand it, the following are possibilities:
Xofigo
(maybe) Provenge BAT Cabitaxol plus Carboplatin (which he will refuse -- the Docetaxol was SO awful, didn't work and he ended up almost in a wheelchair, so if that is the only choice, he will go for hospice.) 225 Actinium (clinical trial
As we understand it, the following are possibilities:
Xofigo
(maybe) Provenge BAT Cabitaxol plus Carboplatin (which he will refuse -- the Docetaxol was SO awful, didn't work and he ended up almost in a wheelchair, so if that is the only choice, he will go for hospice.) 225 Actinium (clinical trial
Biobro
in
Advanced Prostate Cancer
1 year ago
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