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Obinutuzumab
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When will I need treatment? Is Watch and Wait still the best option with newer treatments?
Mayo Clinic has started a clinical trial to test early treatment with Acalabrutinib: ClinicalTrials.gov Identifier: NCT03516617 Recruitment Status : Recruiting First Posted : May 4, 2018 Last Update Posted : September 27, 2018 This phase II trials studies how well acalabrutinib with or without
obinutuzumab
Mayo Clinic has started a clinical trial to test early treatment with Acalabrutinib: ClinicalTrials.gov Identifier: NCT03516617 Recruitment Status : Recruiting First Posted : May 4, 2018 Last Update Posted : September 27, 2018 This phase II trials studies how well acalabrutinib with or without
obinutuzumab
lankisterguy
Volunteer
in
CLL Support
7 years ago
New "kid" on the therapy block
This is a similar approach that is used by mAbs that target CD20 such as Rituxan or
Obinutuzumab
with a twist in that a cytotoxin (SG3199), acting as the CLL cell assassin, is attached biochemically to the CD19 seeking part of ADCT-402 .
This is a similar approach that is used by mAbs that target CD20 such as Rituxan or
Obinutuzumab
with a twist in that a cytotoxin (SG3199), acting as the CLL cell assassin, is attached biochemically to the CD19 seeking part of ADCT-402 .
ThreeWs
in
CLL Support
7 years ago
Obinutuzumab anyone?
I am thinking about participating in a clinical trial which will compare ibrutinib+
obinutuzumab
+venetoclax to ibrutinib+
obinutuzumab
. I have heard of ibrutinib+venetoclax but not
obinutuzumab
. Has anyone had any experience taking this?
I am thinking about participating in a clinical trial which will compare ibrutinib+
obinutuzumab
+venetoclax to ibrutinib+
obinutuzumab
. I have heard of ibrutinib+venetoclax but not
obinutuzumab
. Has anyone had any experience taking this?
eoravillo
in
CLL Support
7 years ago
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Latest update....
Chlorambucil ( Leukeran) and
Obinutuzumab
(gazyvaro). Apparently there will be no loss of hair, possibly mild diarrhoea and hopefully no sickness. She said that these drugs are very good for this Evans Syndrome he has now developed....
Chlorambucil ( Leukeran) and
Obinutuzumab
(gazyvaro). Apparently there will be no loss of hair, possibly mild diarrhoea and hopefully no sickness. She said that these drugs are very good for this Evans Syndrome he has now developed....
Susiecarer
in
CLL Support
7 years ago
New member....new to NHL...new to chemo...so many questions ???
My Dr. said "I think it's time".....and with that I started my first round of chemo this past week using
Obinutuzumab
/ Bendamustine. Just getting thru this first 2 days, kicked my butt for about 3 days. Crazy fatigue paired with nausea.
My Dr. said "I think it's time".....and with that I started my first round of chemo this past week using
Obinutuzumab
/ Bendamustine. Just getting thru this first 2 days, kicked my butt for about 3 days. Crazy fatigue paired with nausea.
Ralbright89
in
Non Hodgkin's Lymphoma Friends
7 years ago
New poster... Tirabrutinib study
Treated with
obinutuzumab
in 2014-2015 with very good results, reaching CR and MRD negative. As a tremendous plus, my RA has also gone into remission! Relapsed two years following end of the
obinutuzumab
treatments.
Treated with
obinutuzumab
in 2014-2015 with very good results, reaching CR and MRD negative. As a tremendous plus, my RA has also gone into remission! Relapsed two years following end of the
obinutuzumab
treatments.
clljon
in
CLL Support
7 years ago
Reassessment of Anti-CD20 Therapy in Lymphoid Malignancies: Impact, Limitations, and New Directions (Rituximab, Ofatumumab and Obinutuzumab)
Two of these agents, ofatumumab and
obinutuzumab
, have been approved for use in certain clinical settings. Research comparing these newer antibodies with rituximab is ongoing.
Two of these agents, ofatumumab and
obinutuzumab
, have been approved for use in certain clinical settings. Research comparing these newer antibodies with rituximab is ongoing.
AussieNeil
Partner
in
CLL Support
7 years ago
My dads cll
He had to go back the next day 28th April, and he was given a full bag of
Obinutuzumab
the only side effect was high temp. He was given the Chlorambucil tablets again he had to go for
Obinutuzumab
again a week later this time he had an high temp.
He had to go back the next day 28th April, and he was given a full bag of
Obinutuzumab
the only side effect was high temp. He was given the Chlorambucil tablets again he had to go for
Obinutuzumab
again a week later this time he had an high temp.
Julie_kerry
in
CLL Support
7 years ago
Explainer: what is chemotherapy and how does it work?
Mabthera/Rituximab, Gazyva/
Obinutuzumab
) and the increased development of personalised medicine. Neil Photo: Correa wildflower
Mabthera/Rituximab, Gazyva/
Obinutuzumab
) and the increased development of personalised medicine. Neil Photo: Correa wildflower
AussieNeil
Partner
in
CLL Support
7 years ago
Obinutuzumab (gazyva)
[i]
Obinutuzumab
spelling corrected - Admin[/i]
[i]
Obinutuzumab
spelling corrected - Admin[/i]
Jemisavs5
in
CLL Support
7 years ago
Update for followers
I started
Obinutuzumab
and venetoclax in march 2016 with 75 percent CLL in my bone marrow aged 47. I had some early challenges but by August I had only 0.08 percent! Mrd positive. Next bone marrow biopsy might show Mrd negative?
I started
Obinutuzumab
and venetoclax in march 2016 with 75 percent CLL in my bone marrow aged 47. I had some early challenges but by August I had only 0.08 percent! Mrd positive. Next bone marrow biopsy might show Mrd negative?
Corin850
in
CLL Support
8 years ago
More Questions on Obinutuzumab (Gazyva) Treatment
Several months ago I posted a question regarding whether my response to initial
obinutuzumab
treatments were normal. I received dozens of helpful, thoughtful replies. Now I'm three months into the treatment regime, with three more monthly infusions to go.
Several months ago I posted a question regarding whether my response to initial
obinutuzumab
treatments were normal. I received dozens of helpful, thoughtful replies. Now I'm three months into the treatment regime, with three more monthly infusions to go.
Ducksoup
in
CLL Support
8 years ago
Cycle 8, Day 1 OSU Obin/Ibrutinib/Venetoclax Trial Update
This past Tuesday, I had my 8th and final
obinutuzumab
treatment. In addition to having no more day long visits to Clinical Treatment Unit for the foreseeable future, I’m also just past the half way point of the trial.
This past Tuesday, I had my 8th and final
obinutuzumab
treatment. In addition to having no more day long visits to Clinical Treatment Unit for the foreseeable future, I’m also just past the half way point of the trial.
thompsonellen
in
CLL Support
8 years ago
Very Delayed Cycle 7 OSU Trial Update
Just one more cycle of
obinutuzumab
(the IV-based treatment) to go. Then, I return for mid-trial testing (bone marrow biopsy (BMB), CT scans, etc.) and after that, I fly out just 5 more times every 4 weeks to pick up meds and have blood work.
Just one more cycle of
obinutuzumab
(the IV-based treatment) to go. Then, I return for mid-trial testing (bone marrow biopsy (BMB), CT scans, etc.) and after that, I fly out just 5 more times every 4 weeks to pick up meds and have blood work.
thompsonellen
in
CLL Support
8 years ago
‘Tis the season for food poisoning: a Christmas warning
So please, have a safe and enjoyable Christmas by being careful what you eat, taking particular care to avoid foods that have not been adequately refrigerated and for those under treatment or recently treated with anti-CD20 antibodies like Rituximab/Mabthera or Gazyva/
Obinutuzumab
, foods not recommended
So please, have a safe and enjoyable Christmas by being careful what you eat, taking particular care to avoid foods that have not been adequately refrigerated and for those under treatment or recently treated with anti-CD20 antibodies like Rituximab/Mabthera or Gazyva/
Obinutuzumab
, foods not recommended
AussieNeil
Partner
in
CLL Support
8 years ago
New Treatments
Obinutuzumab
is an injection which runs over about 4-6 hours. Have any of you tried these treatments? I hope everyone is taking care of themselves!
Obinutuzumab
is an injection which runs over about 4-6 hours. Have any of you tried these treatments? I hope everyone is taking care of themselves!
Jemisavs5
in
CLL Support
8 years ago
Obinutuzumab Treatment--What to Expect
Hello folks, After nearly eight years of slow-growing CLL, I finally had to have treatment. Was hospitalized for a couple of days last week for the first infusion. The day after release I felt more energetic than I have for nearly a year. Then back to symptoms. Fatigue morning until night. Walking
Hello folks, After nearly eight years of slow-growing CLL, I finally had to have treatment. Was hospitalized for a couple of days last week for the first infusion. The day after release I felt more energetic than I have for nearly a year. Then back to symptoms. Fatigue morning until night. Walking
Ducksoup
in
CLL Support
8 years ago
Cycle 5, Day 1 OSU Obin/Ibrutinib/Venetoclax Trial
Day 1 of the first 8 cycles involves the
obinutuzumab
infusion on top of the daily 7 pill regimen of ibrutinib and ventoclax.
Day 1 of the first 8 cycles involves the
obinutuzumab
infusion on top of the daily 7 pill regimen of ibrutinib and ventoclax.
thompsonellen
in
CLL Support
8 years ago
Follicular Lymphoma Patient Survey
Lymphoma Canada is preparing a submission for the panCanadian Oncology Drug Review (pCODR) for: Obinituzumab in combination with chemotherapy, followed by
obinutuzumab
maintenance, for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab containing
Lymphoma Canada is preparing a submission for the panCanadian Oncology Drug Review (pCODR) for: Obinituzumab in combination with chemotherapy, followed by
obinutuzumab
maintenance, for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab containing
LCAdmin
in
Non Hodgkin's Lymphoma Friends
8 years ago
Follicular Lymphoma Patient Survey
Lymphoma Canada is preparing a submission for the panCanadian Oncology Drug Review (pCODR) for: Obinituzumab in combination with chemotherapy, followed by
obinutuzumab
maintenance, for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab containing
Lymphoma Canada is preparing a submission for the panCanadian Oncology Drug Review (pCODR) for: Obinituzumab in combination with chemotherapy, followed by
obinutuzumab
maintenance, for the treatment of patients with follicular lymphoma who relapsed after, or are refractory to, a rituximab containing
LCAdmin
Lymphoma Canada
in
Lymphoma Canada
8 years ago
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