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Obinutuzumab
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Started Clinical trial-obinutuzumab+ venetoclax
Started 3 days ago. Included bendamustine due to lymph size. Day before treatment WBC at 173. After 2 treatments of bene. + obib. WBC at 17. Uric acid up over normal but kidney functions OK. Not much sleep 1st 2 nights but feeling better now. Thoughts and experience with those in this trial appreciated
Started 3 days ago. Included bendamustine due to lymph size. Day before treatment WBC at 173. After 2 treatments of bene. + obib. WBC at 17. Uric acid up over normal but kidney functions OK. Not much sleep 1st 2 nights but feeling better now. Thoughts and experience with those in this trial appreciated
Elam
in
CLL Support
5 years ago
EU Panel Backs Expanded Indication of Ibrutinib Combos in CLL
Friday, Jun 28, 2019 The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended expanding the indications of ibrutinib (Imbruvica) to include use in combination with
obinutuzumab
(Gazyva) for adult patients with previously untreated chronic lymphocytic leukemia
Friday, Jun 28, 2019 The European Medicines Agency’s Committee for Medicinal Products for Human Use (CHMP) has recommended expanding the indications of ibrutinib (Imbruvica) to include use in combination with
obinutuzumab
(Gazyva) for adult patients with previously untreated chronic lymphocytic leukemia
Jm954
Administrator
in
CLL Support
5 years ago
Mode of Progression After Frontline Treatment Predicts Clinical Outcomes in Patients With CLL
[/i] The clinical trials included in the evaluation were FCR vs FC, FCR vs BR and
obinutuzumab
in combination with chlorambucil as compared to rituximab plus chlorambucil or chlorambucil.
[/i] The clinical trials included in the evaluation were FCR vs FC, FCR vs BR and
obinutuzumab
in combination with chlorambucil as compared to rituximab plus chlorambucil or chlorambucil.
AussieNeil
Partner
in
CLL Support
5 years ago
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YABTKi or Yet Another BTK inhibitor - the A to Z list of Bruton's Tyrosine Kinase Inhibitors for CLL following Ibrutinib's success
healthunlocked.com/cllsupport/posts/150750709/cll-a-summary-of-treatments-now-that-we-have-a-range-of-new-drugs
Jennifer Woyach, MD, Associate Professor in the Division of Hematology at The Ohio State University
1) Highlights Role of BTK Inhibition in Treatment Landscape for CLL (along with Ventoclax,
Obinutuzumab
healthunlocked.com/cllsupport/posts/150750709/cll-a-summary-of-treatments-now-that-we-have-a-range-of-new-drugs
Jennifer Woyach, MD, Associate Professor in the Division of Hematology at The Ohio State University
1) Highlights Role of BTK Inhibition in Treatment Landscape for CLL (along with Ventoclax,
Obinutuzumab
AussieNeil
Partner
in
CLL Support
5 years ago
Article in NEJM on Venetoclax & Obinutuzumab
Here is an article that was just received from the New England Journal of Medicine that some may find of interest. Jack O. https://www.nejm.org/doi/full/10.1056/NEJMoa1815281?query=oncology-hematology
Here is an article that was just received from the New England Journal of Medicine that some may find of interest. Jack O. https://www.nejm.org/doi/full/10.1056/NEJMoa1815281?query=oncology-hematology
jdolinger
in
CLL Support
5 years ago
With a CLL diagnosis, knowing more about your immune system could save your life!
or rituximab treatment https://healthunlocked.com/cllsupport/posts/130895083/late-onset-neutropenia-may-be-a-complication-of-fcr-or-rituximab-
obinutuzumab
-or-other-anti-cd20-monoclonal-antibody-infusions-admin
- Sepsis/Febrile Neutropenia/Neutropenic Fever - blood poisoning
(This [u]potentially
or rituximab treatment https://healthunlocked.com/cllsupport/posts/130895083/late-onset-neutropenia-may-be-a-complication-of-fcr-or-rituximab-
obinutuzumab
-or-other-anti-cd20-monoclonal-antibody-infusions-admin
- Sepsis/Febrile Neutropenia/Neutropenic Fever - blood poisoning
(This [u]potentially
AussieNeil
Partner
in
CLL Support
5 years ago
42% of patients achieved U-MRD6 with venetoclax + obinutuzumab!
From German CLL14 study, presented at IMCL 2019. source: https://twitter.com/anthonymatomd/status/1141680121646145541 overview of UMRD-6: https://healthunlocked.com/cllsupport/posts/139267149/u-mrd6-is-the-new-mrd
From German CLL14 study, presented at IMCL 2019. source: https://twitter.com/anthonymatomd/status/1141680121646145541 overview of UMRD-6: https://healthunlocked.com/cllsupport/posts/139267149/u-mrd6-is-the-new-mrd
avzuclav
in
CLL Support
5 years ago
FDA Frontline Approval of Venetoclax and Obinituzumab in the USA
Hi, Venetoclax in combination with
obinutuzumab
has been approved frontline for CLL. This is the first fixed duration non-chemo approach for CLL.
Hi, Venetoclax in combination with
obinutuzumab
has been approved frontline for CLL. This is the first fixed duration non-chemo approach for CLL.
bkoffman
CLL CURE Hero
in
CLL Support
5 years ago
Update #2 to “ Treatment Begins”
Of
Obinutuzumab
started with labs 5:15 am. Imbrutinib places on hold til Monday restart Labs came back ok on potassium level. 7:00 am Had a nurse assigned just for me.
Of
Obinutuzumab
started with labs 5:15 am. Imbrutinib places on hold til Monday restart Labs came back ok on potassium level. 7:00 am Had a nurse assigned just for me.
Coolerjoe
in
CLL Support
5 years ago
Treatment begins
Got the trifecta of my trial Imbrutinib
Obinutuzumab
Venetoclax to start in 3 months. Had a tough reaction Monday so pulled off
obinutuzumab
to dilute or reduce dose. Admitted to RWJ Cancer Institute will start back up this morning. 100 ml Then tomorrow the remaining 900ml.
Got the trifecta of my trial Imbrutinib
Obinutuzumab
Venetoclax to start in 3 months. Had a tough reaction Monday so pulled off
obinutuzumab
to dilute or reduce dose. Admitted to RWJ Cancer Institute will start back up this morning. 100 ml Then tomorrow the remaining 900ml.
Coolerjoe
in
CLL Support
5 years ago
Update to “ Treatment Begins”
Then you may know that the introduction of
Obinutuzumab
did not go well. Had a reaction on Monday. Sent home that evening. Brought back into RWJ CI and admitted on Tuesday afternoon.
Then you may know that the introduction of
Obinutuzumab
did not go well. Had a reaction on Monday. Sent home that evening. Brought back into RWJ CI and admitted on Tuesday afternoon.
Coolerjoe
in
CLL Support
5 years ago
Update #3 Treatment Begins
Well i am back in the hospital for my second infusion of
Obinutuzumab
( Better safe than sorry monitoring ) Looks like another striated infusion today. 12.5 ml for 1/2 hour. If tolerated up to 25 for 1/2. Slowly climbing to a max of 200 ml. So this one should take roughly 7 hours.
Well i am back in the hospital for my second infusion of
Obinutuzumab
( Better safe than sorry monitoring ) Looks like another striated infusion today. 12.5 ml for 1/2 hour. If tolerated up to 25 for 1/2. Slowly climbing to a max of 200 ml. So this one should take roughly 7 hours.
Coolerjoe
in
CLL Support
5 years ago
FDA APPROVES VENETOCLAX/OBINUTUZUMAB
For treatment-naive CLL patients. This is a fixed duration treatment!!! Great news!!
For treatment-naive CLL patients. This is a fixed duration treatment!!! Great news!!
Motoli
in
CLL Support
5 years ago
Upcoming CLL17 trial: (obinutuzumab + venetoclax) versus (ibrutinib + venetoclax) versus (ibrutinib monotherapy)
Once again, big thanks to the German CLL Study Group! https://twitter.com/HallekMichael/status/1136141658809143301
Once again, big thanks to the German CLL Study Group! https://twitter.com/HallekMichael/status/1136141658809143301
avzuclav
in
CLL Support
5 years ago
Has anyone been on the combination therapy of Venetoclax, Ibrutinib and Obinutuzumab?
I was wondering if I could hear from someone who has had the combination of Venetoclax, Ibrutinib and
Obinutuzumab
(Gazyva). My CLL is completely resistant to Chemo and actually continued to spread while I was on FCR. Basically I have a rare c-myc mutation for CLL that has a poor prognosis.
I was wondering if I could hear from someone who has had the combination of Venetoclax, Ibrutinib and
Obinutuzumab
(Gazyva). My CLL is completely resistant to Chemo and actually continued to spread while I was on FCR. Basically I have a rare c-myc mutation for CLL that has a poor prognosis.
Time17
in
CLL Support
5 years ago
I am CLL patient previusly treate with FR. I need to be treated again. I need some advice please.
(Rituximab plus Fludarabina) 2-
Obinutuzumab
plus chlorambucil. My Doctor recommends 2nd Option. According to my Doctor, Obinutuzmab (gazyvo) can be used also for patient previously treated. Can anyone give some clue/advice about this.
(Rituximab plus Fludarabina) 2-
Obinutuzumab
plus chlorambucil. My Doctor recommends 2nd Option. According to my Doctor, Obinutuzmab (gazyvo) can be used also for patient previously treated. Can anyone give some clue/advice about this.
tropicsurvivor
in
CLL Support
6 years ago
Ibrutinib and Obinutuzumab with Venetoclax
Hello, I am new here. My husband needs to start first time treatment for CLL as soon as possible. He was given info. about the clinical trial which adds Venetoclax to Ibrutinib and Obinutuzmab. Half of the participants will receive the Venetoclax. His other option is to be given just the Ibrutinib.
Hello, I am new here. My husband needs to start first time treatment for CLL as soon as possible. He was given info. about the clinical trial which adds Venetoclax to Ibrutinib and Obinutuzmab. Half of the participants will receive the Venetoclax. His other option is to be given just the Ibrutinib.
Johnnyislander
in
CLL Support
6 years ago
Clinical trial for Imbruvica/Ibrutinib , Gazyva/Obinutuzumab +/- Venclexta/Venetoclax at 97 sites USA
A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and
Obinutuzumab
Versus Ibrutinib and
Obinutuzumab
in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL) https://clinicaltrials.gov/ct2/show/NCT03701282 Per Dr.
A Randomized Phase III Study of the Addition of Venetoclax to Ibrutinib and
Obinutuzumab
Versus Ibrutinib and
Obinutuzumab
in Untreated Younger Patients With Chronic Lymphocytic Leukemia (CLL) https://clinicaltrials.gov/ct2/show/NCT03701282 Per Dr.
lankisterguy
Volunteer
in
CLL Support
6 years ago
REGARDING MY EXPERIENCE
MY EXPERIENCE WAS WITH
OBINUTUZUMAB
AND CLORAMBUCIL LEUKERAN + GAZYBA SORRY
MY EXPERIENCE WAS WITH
OBINUTUZUMAB
AND CLORAMBUCIL LEUKERAN + GAZYBA SORRY
giuliano
in
CLL Support
6 years ago
Clinical trial
Ibrutinib Venetoax
Obinutuzumab
cancerfree since January 2018 Going in for checkups every 3 months
Ibrutinib Venetoax
Obinutuzumab
cancerfree since January 2018 Going in for checkups every 3 months
mickimauser11
in
CLL Support
6 years ago
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