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Three-drug GIV combo promising against high-risk CLL - Patients with deletion 17p or TP53 (from EHA Congress)
[i]For patients with high-risk chronic lymphocytic leukemia (CLL), first-line therapy with a triple combination of targeted agents
obinutuzumab
(Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) showed encouraging response rates in the phase 2 CLL2-GIVe trial.
[i]For patients with high-risk chronic lymphocytic leukemia (CLL), first-line therapy with a triple combination of targeted agents
obinutuzumab
(Gazyva), ibrutinib (Imbruvica), and venetoclax (Venclexta) showed encouraging response rates in the phase 2 CLL2-GIVe trial.
AussieNeil
Partner
in
CLL Support
4 years ago
Ibrutinib or venetoclax-obinutuzumab
Ibrutinib or venetoclax-
obinutuzumab
? This will be my first treatment option following CLL diagnosis. Thanks. Happy to provide specific numbers from my chart if that helps.
Ibrutinib or venetoclax-
obinutuzumab
? This will be my first treatment option following CLL diagnosis. Thanks. Happy to provide specific numbers from my chart if that helps.
Hidden
in
CLL Support
4 years ago
Hiccups?
My husband's SLL did not respond adequately to Ibrutinib and he is being transitioned to
Obinutuzumab
infusions for 6 months and starting Venetoclax orally in a month. He just finished his first 2 high dose infusions as inpatient at the VA. He now has horrible hiccups.
My husband's SLL did not respond adequately to Ibrutinib and he is being transitioned to
Obinutuzumab
infusions for 6 months and starting Venetoclax orally in a month. He just finished his first 2 high dose infusions as inpatient at the VA. He now has horrible hiccups.
alexismitchell51
in
CLL Support
4 years ago
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Unmutated patients on venetoclax?
In it, she refers to the trial where patients on venetoclax +
obinutuzumab
had much better results than those on chlorambucil +
obinutuzumab
. However, she also noted that mutated patients on both treatments fared better than unmutated patients.
In it, she refers to the trial where patients on venetoclax +
obinutuzumab
had much better results than those on chlorambucil +
obinutuzumab
. However, she also noted that mutated patients on both treatments fared better than unmutated patients.
HikerBiker
in
CLL Support
4 years ago
Can Venetoclax/Obinituzimab reduce the risk of additional somatic mutations? - Not necessarily. The BTK inhibitors are excellent at....
The same is not true for venetoclax/
obinutuzumab
. - Ultimately, the only data we have thus far is comparing single agent ibrutinib from one study to single agent venetoclax (or venetoclax/
obinutuzumab
) in another study.
The same is not true for venetoclax/
obinutuzumab
. - Ultimately, the only data we have thus far is comparing single agent ibrutinib from one study to single agent venetoclax (or venetoclax/
obinutuzumab
) in another study.
lankisterguy
Volunteer
in
CLL Support
4 years ago
Hoping to turn a corner on this long road...sorry in advance for a long intro...it's been a long road
So he starts Gazyva (
obinutuzumab
) on Wednesday this coming week (9/9). I've researched the heck out of it. I'm stressed that I can't be there with him (I'm his brain surrogate when he's "fogged in"). And I've read so many of your experiences here. We're at a great cancer center.
So he starts Gazyva (
obinutuzumab
) on Wednesday this coming week (9/9). I've researched the heck out of it. I'm stressed that I can't be there with him (I'm his brain surrogate when he's "fogged in"). And I've read so many of your experiences here. We're at a great cancer center.
VidaPlaya
in
CLL Support
4 years ago
Venetoclax plus obinutuzumab - the first chemotherapy-free, fixed-duration first line CLL treatment approved by Health Canada
residual disease compared to patients receiving a standard of care chemoimmunotherapy regimen of
obinutuzumab
and chlorambucil[/i] https://www.bloomberg.com/press-releases/2020-05-05/abbvie-receives-health-canada-approval-for-the-combination-of-venclexta-venetoclax-with-
obinutuzumab
-for-patients-with-prev
residual disease compared to patients receiving a standard of care chemoimmunotherapy regimen of
obinutuzumab
and chlorambucil[/i] https://www.bloomberg.com/press-releases/2020-05-05/abbvie-receives-health-canada-approval-for-the-combination-of-venclexta-venetoclax-with-
obinutuzumab
-for-patients-with-prev
AussieNeil
Partner
in
CLL Support
4 years ago
Good evening! My father was diagnosed 9 months ago. Treatment(obinutuzumab)& such has been taking its course.
I was hoping if anyone can guide/advise me in regards to his irregular blood sugars (while still in treatment). Existing type 2 DM. Controlled diet + exercise, yet it ranges from 200-216 mg/dL. All help is much appreciated. Best.
I was hoping if anyone can guide/advise me in regards to his irregular blood sugars (while still in treatment). Existing type 2 DM. Controlled diet + exercise, yet it ranges from 200-216 mg/dL. All help is much appreciated. Best.
anbazdaya
in
CLL Support
4 years ago
B-PLL: Ibrutrinib Monotherapy or Obinutuzumab (aka Gazyva) & Venetoclax Combination as first-line treatment for transformed CLL
Hi Everyone, I'm new to this group. My Dad has CLL with a B-PLL transformation in his lymph nodes. He has good genetic markers (TP53 unmutated, 17P undeleted) but is IGHV unmutated. We have two CLL experts who propose different treatment plans for first-line therapy: 1) Monotherapy Ibrutinib or Acalabrutinib
Hi Everyone, I'm new to this group. My Dad has CLL with a B-PLL transformation in his lymph nodes. He has good genetic markers (TP53 unmutated, 17P undeleted) but is IGHV unmutated. We have two CLL experts who propose different treatment plans for first-line therapy: 1) Monotherapy Ibrutinib or Acalabrutinib
Phs2385
in
CLL Support
4 years ago
Frontline Venetoclax/Obinutuzumab Approved in Europe for CLL
In some welcome good news[i], "The European Commission has approved a fixed-dose combination of venetoclax (Venclexta) and
obinutuzumab
(Gazyva) for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL)"[/i] https://www.onclive.com/web-exclusives/frontline-venetoclaxobinutuzumab-approved-in-europe-in-cll
In some welcome good news[i], "The European Commission has approved a fixed-dose combination of venetoclax (Venclexta) and
obinutuzumab
(Gazyva) for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL)"[/i] https://www.onclive.com/web-exclusives/frontline-venetoclaxobinutuzumab-approved-in-europe-in-cll
AussieNeil
Partner
in
CLL Support
5 years ago
Treatment continues and lymph nodes responding-amazingly!
I have have my third infusion but really only finished my second full dosage of
Obinutuzumab
as the first vial is split into 2 days. So far I have had no side effects other than a mild headache every now and then. I have been able to come home do yoga, cook, laundry etc without any letting up!!!
I have have my third infusion but really only finished my second full dosage of
Obinutuzumab
as the first vial is split into 2 days. So far I have had no side effects other than a mild headache every now and then. I have been able to come home do yoga, cook, laundry etc without any letting up!!!
Loveroflife
in
CLL Support
5 years ago
Not very happy with this It is very depressing and another battle Has anyone had this experence? I am not getting much of an explanation !!!
My Dr started me on Gayza,
Obinutuzumab
Chemo. I am gaining weight from this. I would like to know Why What does it do to the body that causes weight gain. I would like to stop the chemo, besides feeling tired with no energy.
My Dr started me on Gayza,
Obinutuzumab
Chemo. I am gaining weight from this. I would like to know Why What does it do to the body that causes weight gain. I would like to stop the chemo, besides feeling tired with no energy.
gelato
in
CLL Support
5 years ago
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
Molecular modeling as shown above is beginning to reveal information about the differences in the mechanisms of action of various monoclonal anti-CD20 antibodies such as rituximab (RTX; Rituxan) and
obinutuzumab
(OBZ; Gazyva). Edited text below has been lifted from the paper.
Molecular modeling as shown above is beginning to reveal information about the differences in the mechanisms of action of various monoclonal anti-CD20 antibodies such as rituximab (RTX; Rituxan) and
obinutuzumab
(OBZ; Gazyva). Edited text below has been lifted from the paper.
gardening-girl
in
CLL Support
5 years ago
Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory CLL
Acalabrutinib plus
obinutuzumab
was well tolerated, producing high and durable responses in treatment-naïve and relapsed/refractory CLL.
Acalabrutinib plus
obinutuzumab
was well tolerated, producing high and durable responses in treatment-naïve and relapsed/refractory CLL.
Jm954
Administrator
in
CLL Support
5 years ago
O + V & Antibiotics?
Does anyone here know which—if any—antibiotics someone being treated with
Obinutuzumab
& Venetoclax should avoid? Just curious. Read something about that once, but can’t seem to remember it, nor re-find it. —Dave!
Does anyone here know which—if any—antibiotics someone being treated with
Obinutuzumab
& Venetoclax should avoid? Just curious. Read something about that once, but can’t seem to remember it, nor re-find it. —Dave!
DRM18
in
CLL Support
5 years ago
Please share experience of venetoclax plus obinutuzimab or acalabrutinib mono treatment in an important survey
Venetoclax (Venclexta) +
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL Acalabrutinib (Calquence) +
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL Acalabrutinib (Calquence) monotherapy for first-line treatment of CLL/SLL Acalabrutinib (Calquence) monotherapy for treatment of relapsed
Venetoclax (Venclexta) +
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL Acalabrutinib (Calquence) +
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL Acalabrutinib (Calquence) monotherapy for first-line treatment of CLL/SLL Acalabrutinib (Calquence) monotherapy for treatment of relapsed
Jm954
Administrator
in
CLL Support
5 years ago
What to expect from v + o initial treatment
I am a 77 year old male about to start venetoclax +
obinutuzumab
. What should I be aware of during the first stages of the treatment? I'm obviously concerned and would like to go in as psychologically prepared as I can be. Thank you in advance for your advice.
I am a 77 year old male about to start venetoclax +
obinutuzumab
. What should I be aware of during the first stages of the treatment? I'm obviously concerned and would like to go in as psychologically prepared as I can be. Thank you in advance for your advice.
ronsolo306
in
CLL Support
5 years ago
CLL Treatment Advice/Recommendations/Etc For Newbie
After monitoring for 1 year, my doc has recommended that I participate in Trial #EA9161, a 19-month program using ibrutinib,
obinutuzumab
, & venetoclax.
After monitoring for 1 year, my doc has recommended that I participate in Trial #EA9161, a 19-month program using ibrutinib,
obinutuzumab
, & venetoclax.
username-the-dude
in
CLL Support
5 years ago
O + V: Update Two!
(No
Obinutuzumab
infusion this week: not until next Friday.) Got IV hydration at the clinic at 10am, just to be safe. (Dr’s orders.) Got a blood draw at 12:30pm, checking for Tumor Lysis, of which there were no signs. Probably helped that, overall, I imbibed around 130 ounces of fluids today(!).
(No
Obinutuzumab
infusion this week: not until next Friday.) Got IV hydration at the clinic at 10am, just to be safe. (Dr’s orders.) Got a blood draw at 12:30pm, checking for Tumor Lysis, of which there were no signs. Probably helped that, overall, I imbibed around 130 ounces of fluids today(!).
DRM18
in
CLL Support
5 years ago
Please share experience of venetoclax plus obinutuzimab or acalabrutinib treatment in a survey that may help others gain access?
(Gazyva) for first-line treatment of CLL/SLL 2.Acalabrutinib (Calquence) with or without
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL 3.Acalabrutinib (Calquence) monotherapy for treatment of relapsed/refractory CLL/SLL BY COMPLETING THIS SURVEY, YOU ARE PART OF THE PROCESS THAT MAY HELP
(Gazyva) for first-line treatment of CLL/SLL 2.Acalabrutinib (Calquence) with or without
obinutuzumab
(Gazyva) for first-line treatment of CLL/SLL 3.Acalabrutinib (Calquence) monotherapy for treatment of relapsed/refractory CLL/SLL BY COMPLETING THIS SURVEY, YOU ARE PART OF THE PROCESS THAT MAY HELP
HAIRBEAR_UK
Administrator
in
CLL Support
5 years ago
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