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Hemin may be useful as prodrug for prostate cancer. It strongly induced caspase-3 activation, PARP degradation, and apoptosis in PC-3 cells
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Only an invitro study but Hemin is already used to treat acute porphyria. “Given that hemin has been safely administered as a daily infusion at doses ranging from 1 to 4 mg/kg for 3 to 14 days in the treatment of porphyria [32], it holds significant promise for drug development.” Anticancer Effect of
Graham49
in
Fight Prostate Cancer
15 days ago
Typical Diet
I'm having difficulty getting a diet that I like. I'm S4 Fibrosis, 13.4 kpg (I was 36.6!) but lost 2 stone but I'm now stuck. I'm T2 diabetic but that's now well controlled with 1 Metformin daily and a weekly Ozempic injection. I've had a few hypos lately and have eaten sweets etc to bring my level up
I'm having difficulty getting a diet that I like. I'm S4 Fibrosis, 13.4 kpg (I was 36.6!) but lost 2 stone but I'm now stuck. I'm T2 diabetic but that's now well controlled with 1 Metformin daily and a weekly Ozempic injection. I've had a few hypos lately and have eaten sweets etc to bring my level up
Robert1220
in
British Liver Trust
1 year ago
Looking for advice for my newly diagnosed dad
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Hello, I was wondering if you can offer some thoughts on my dad’s situation. He was diagnosed with prostate cancer in February after a week in hospital with urine retention. A Ct scan he had in hospital showed 2 small mets in pelvic area. He’s had a biopsy which showed Gleason 4 +5 and his PSA in hospital
Springsunshi
in
Advanced Prostate Cancer
6 months ago
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help with iron levels please for RLS, please?
Following all the helpful advice on here to raise my iron levels, I have been taking iron since February. My levels then were Serum Ferritin 19 ug/L Transferrin Sat. Index 24% Serum Iron 15.5 umo/l As advised on here, I have been taking 100mg iron bisglycinate every other night, with vit C, on an
Following all the helpful advice on here to raise my iron levels, I have been taking iron since February. My levels then were Serum Ferritin 19 ug/L Transferrin Sat. Index 24% Serum Iron 15.5 umo/l As advised on here, I have been taking 100mg iron bisglycinate every other night, with vit C, on an
Lacey_
in
Restless Legs Syndrome
16 days ago
B12 Deficiency
hi everyone, just wanting peoples thoughts or advice on the following: I had a B12 serum test done which showed my B12 was low at 188 on the 28th of august. This was repeated on September the 2nd and came out at 232 without treatment. My intrinsic factor was also negative. I have loads of B12 symptoms
hi everyone, just wanting peoples thoughts or advice on the following: I had a B12 serum test done which showed my B12 was low at 188 on the 28th of august. This was repeated on September the 2nd and came out at 232 without treatment. My intrinsic factor was also negative. I have loads of B12 symptoms
Hammy2024
in
Pernicious Anaemia Society
16 days ago
End of fixed duration treatment
Completed 2 yr treatment on Rituximab and Venetoclax approximately 4 weeks ago. Consultant says I'm in remission and not to worry there are other treatments I can have. That kind of took any euphoria out of my sails!Still suffering from GI problems constant visits to the loo. Colonoscopy shows some
Completed 2 yr treatment on Rituximab and Venetoclax approximately 4 weeks ago. Consultant says I'm in remission and not to worry there are other treatments I can have. That kind of took any euphoria out of my sails!Still suffering from GI problems constant visits to the loo. Colonoscopy shows some
Fastbike14
in
CLL Support
17 days ago
Picolax bowel prep
Hi hope all is well, I am currently in a mild flare up again due to change in weather temperatures as I seem to get flare-ups every autumn/winter and always fine in the summer is very strange. Anyway I am booked for a sigmoidoscopy in October and will be given Picolax just wondering how others were with
Hi hope all is well, I am currently in a mild flare up again due to change in weather temperatures as I seem to get flare-ups every autumn/winter and always fine in the summer is very strange. Anyway I am booked for a sigmoidoscopy in October and will be given Picolax just wondering how others were with
Sooty712
in
Crohn's and Colitis Support
17 days ago
Bad Diarrhoea & Gas
I’m sorry if this post sounds quite rank, but I just wondered if anyone else is experiencing this. For the last 4 days I have been getting stomach cramps, and my stomach has been doing a lot of churning noises, which lead to really really bad gas and diarrhoea! It’s been 4 days in a row now, at night
I’m sorry if this post sounds quite rank, but I just wondered if anyone else is experiencing this. For the last 4 days I have been getting stomach cramps, and my stomach has been doing a lot of churning noises, which lead to really really bad gas and diarrhoea! It’s been 4 days in a row now, at night
KateD2707
in
Fertility Network UK
17 days ago
Review: The Latest Data Concerning the Etiology and Pathogenesis of Irritable Bowel Syndrome (IBS)
Abstract
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on healthcare
Abstract
Globally, irritable bowel syndrome (IBS) is present in approximately 10% of the population. While this condition does not pose a risk of complications, it has a substantial impact on the patient’s quality of life. Moreover, this disease has a significant financial impact on healthcare
Meleber
in
IBS Network
17 days ago
Bowel Endo?
Saw GP last week and stool results came back with very raised Calprotectin (inflammation) and Blood in stools (FIT test). I’ve now been referred on the urgent 2-week ?cancer pathway, could also be IBD with results so now waiting on an urgent colonoscopy. Could this be bowel endo? Lots of overlapping
Saw GP last week and stool results came back with very raised Calprotectin (inflammation) and Blood in stools (FIT test). I’ve now been referred on the urgent 2-week ?cancer pathway, could also be IBD with results so now waiting on an urgent colonoscopy. Could this be bowel endo? Lots of overlapping
Claire_Alexandra
in
Endometriosis UK
18 days ago
Is this piles
I was told after a colonoscopy that I have internal piles. Often after a large bowel movement I have a horrible burning and heavy feeling down below. Hard to describe but can last days and drive me mad!!! Is this really the piles there was no blood?
I was told after a colonoscopy that I have internal piles. Often after a large bowel movement I have a horrible burning and heavy feeling down below. Hard to describe but can last days and drive me mad!!! Is this really the piles there was no blood?
Edgar77
in
IBS Network
18 days ago
TWISTED BOWELS (VOLVULUS) FOLLOWING PROSTATE SURGERY.
my partner keeps getting twisted bowels, the medical diagnosis is VOLVULUS, following TURP prostate surgery, for a very enlarged prostate that pressed on the colorectal bowels. Following surgery, the colorectal bowels became floppy and he keeps getting twisted bowels and must undergo an immediate
my partner keeps getting twisted bowels, the medical diagnosis is VOLVULUS, following TURP prostate surgery, for a very enlarged prostate that pressed on the colorectal bowels. Following surgery, the colorectal bowels became floppy and he keeps getting twisted bowels and must undergo an immediate
catherine1712
in
Crohn's and Colitis Support
18 days ago
Ibs bam
Anyone on here have bile acid malabsorption if so wat medication are yous on and do yous get really bad stomach pains even though on medication as I have bam on colesevelam but still get horrible stomach pain I have ibs aswell and docs are saying it's overlapping eachother watever that is supposed to
Anyone on here have bile acid malabsorption if so wat medication are yous on and do yous get really bad stomach pains even though on medication as I have bam on colesevelam but still get horrible stomach pain I have ibs aswell and docs are saying it's overlapping eachother watever that is supposed to
Netbet22
in
IBS Network
18 days ago
Colonoscopy/gastroscopy
Hello, me again! Or should I say “g’day”? I’ve just had my first ever hospital procedure with sedation - A colonoscopy and gastroscopy (top and tail) to check why I might not be absorbing B12 and iron. I’ve been terrified about it for so long and it was a complete non-event. The hospital staff were
Hello, me again! Or should I say “g’day”? I’ve just had my first ever hospital procedure with sedation - A colonoscopy and gastroscopy (top and tail) to check why I might not be absorbing B12 and iron. I’ve been terrified about it for so long and it was a complete non-event. The hospital staff were
PlatypusProfit8077
in
Pernicious Anaemia Society
18 days ago
Eat Real Food and Protect Your Microbiome
I don't have the answers, but the questions are worth looking at. My High School education tells me that PD might start in the gut. This makes sense to me. Therefore, gut inflammation is probably bad, and probably leads to intestinal permeability (leaky gut). And the gut bone is connected to the brain
I don't have the answers, but the questions are worth looking at. My High School education tells me that PD might start in the gut. This makes sense to me. Therefore, gut inflammation is probably bad, and probably leads to intestinal permeability (leaky gut). And the gut bone is connected to the brain
Bolt_Upright
in
Cure Parkinson's
18 days ago
Screening for Colorectal Cancer
There are several tests, some of which can be done at home.👏😃 Most people should begin screening for colorectal cancer soon after turning 45.🤔👍 You may need to be tested [u]
earlier than 45, or more often than other people
[/u], if you have: * Inflammatory bowel disease such as Crohn's disease
There are several tests, some of which can be done at home.👏😃 Most people should begin screening for colorectal cancer soon after turning 45.🤔👍 You may need to be tested [u]
earlier than 45, or more often than other people
[/u], if you have: * Inflammatory bowel disease such as Crohn's disease
GCCA-Survivor
Administrator
in
Colon Cancer Connected
19 days ago
Recommended iron levels
With regard to iron, there is really only one correct way to test a patient's four iron levels. This information is from The Johns Hopkins University & Medical Center in Maryland, USA. Listed below are the four iron parameters, the "normal" limits for men and women, and the recommended levels for RLS
With regard to iron, there is really only one correct way to test a patient's four iron levels. This information is from The Johns Hopkins University & Medical Center in Maryland, USA. Listed below are the four iron parameters, the "normal" limits for men and women, and the recommended levels for RLS
fritzb43
in
Restless Legs Syndrome
19 days ago
How do I cope with a pain that no one believes is real?
I hope it is okay to post this here; I just feel totally consumed by my pain at the moment, and lost, as well as alone, in the journey of figuring it out. It all started 7 years ago, when I was 18- a nagging sharp pain started at the top of my abdomen, between my ribs, which lasted a few days. One morning
I hope it is okay to post this here; I just feel totally consumed by my pain at the moment, and lost, as well as alone, in the journey of figuring it out. It all started 7 years ago, when I was 18- a nagging sharp pain started at the top of my abdomen, between my ribs, which lasted a few days. One morning
BraveheartPenguin
in
Pain Concern
21 days ago
Pulmonary metastasectomy anyone?
HI , I am (almost) 60 years old and have ER+ her- metastatic breast cancer. My cancer returned after first being diagnosed 12 years . I have several tumours in my right lung. I have been stable on ibrance and letrozole for 2 years (hoping and praying for this good quality of life to continue). I
HI , I am (almost) 60 years old and have ER+ her- metastatic breast cancer. My cancer returned after first being diagnosed 12 years . I have several tumours in my right lung. I have been stable on ibrance and letrozole for 2 years (hoping and praying for this good quality of life to continue). I
Kahe
in
SHARE Metastatic Breast Cancer
6 months ago
constipation after diverticular flare up
Last month I had 3 flare ups and everytime I had such severe diarrohea that I completely emptied my bowel. I now am constipated. I have been constipated my whole life, nothing helps, fibre included, and taking senna ends up with crippling pain. I have discovered Lactulose and find that this works
Last month I had 3 flare ups and everytime I had such severe diarrohea that I completely emptied my bowel. I now am constipated. I have been constipated my whole life, nothing helps, fibre included, and taking senna ends up with crippling pain. I have discovered Lactulose and find that this works
alice1125
in
Bowel Disease Support
21 days ago
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