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Enzalutamide
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STAMPEDE - Zytiga at ADT initiation. NEJM Paper.
Several agents have improved overall survival (docetaxel, abiraterone acetate,
enzalutamide
, cabazitaxel, radium-223, and sipuleucel-T)1-8 or reduced morbidity (zoledronic acid and denosumab)9-11 among such patients.
Several agents have improved overall survival (docetaxel, abiraterone acetate,
enzalutamide
, cabazitaxel, radium-223, and sipuleucel-T)1-8 or reduced morbidity (zoledronic acid and denosumab)9-11 among such patients.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Natural killer cells suppress enzalutamide resistance and cell invasion in CRPC via targeting ARv7.
KEYWORDS: ARv7;
Enzalutamide
; Natural Killer cells PMID: 28373004 DOI: 10.1016/j.canlet.2017.03.035
KEYWORDS: ARv7;
Enzalutamide
; Natural Killer cells PMID: 28373004 DOI: 10.1016/j.canlet.2017.03.035
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Update
By way of an update - my PSA has been quickly rising - 29 at last test so my onco has changed me from the bicalutamide to
enzalutamide
and I am having CT and bone scans in July - very disappointing after a PSA of 0.65 in Jan and hope that I was 'good for a year or two'.
By way of an update - my PSA has been quickly rising - 29 at last test so my onco has changed me from the bicalutamide to
enzalutamide
and I am having CT and bone scans in July - very disappointing after a PSA of 0.65 in Jan and hope that I was 'good for a year or two'.
wilko_1
in
Fight Prostate Cancer
7 years ago
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BAT: Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of CRPC.
A trial comparing
enzalutamide
against BAT is ongoing." I suppose that I bristle a little when I read "paradoxical" & "supraphysiologic". It is well-established that ADT causes CRPC. In fact, the price of ADT is accelerated aggressive disease.
A trial comparing
enzalutamide
against BAT is ongoing." I suppose that I bristle a little when I read "paradoxical" & "supraphysiologic". It is well-established that ADT causes CRPC. In fact, the price of ADT is accelerated aggressive disease.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Foods/Supplements-Vitamins: Cruciferous Phytochemicals - [3] 3,3'-Diindolylmethane [DIM]
Our preclinical and clinical studies provide the scientific basis for a “proof-of-concept” clinical trial in CRPC patients treated with
enzalutamide
in combination with BR-DIM." [2c] (2016 - U.S. - pre-prostatectomy study.)
Our preclinical and clinical studies provide the scientific basis for a “proof-of-concept” clinical trial in CRPC patients treated with
enzalutamide
in combination with BR-DIM." [2c] (2016 - U.S. - pre-prostatectomy study.)
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Medicines to b avoided with Ibnutrib
medications that shouldn’t be consumed while taking this drug are: · Abiraterone · Amprenavir · Aprepitant · Carbamazepine · Ciprofloxacin · Clarithromycin · Conivaptan · Crizotinib · Darunavir · Delavirdine · Diltiazem ·
Enzalutamide
medications that shouldn’t be consumed while taking this drug are: · Abiraterone · Amprenavir · Aprepitant · Carbamazepine · Ciprofloxacin · Clarithromycin · Conivaptan · Crizotinib · Darunavir · Delavirdine · Diltiazem ·
Enzalutamide
Anilbhard
in
CLL Support
8 years ago
Advanced Prostate Cancer: Research Update
Making the Most of Hormone Therapy Some of the most exciting research focuses on how and when to best use two drugs, abiraterone acetate (Zytiga) and
enzalutamide
(Xtandi). They bring testosterone levels down to almost nothing, which starves prostate cancer cells of that hormonal fuel.
Making the Most of Hormone Therapy Some of the most exciting research focuses on how and when to best use two drugs, abiraterone acetate (Zytiga) and
enzalutamide
(Xtandi). They bring testosterone levels down to almost nothing, which starves prostate cancer cells of that hormonal fuel.
motosue
in
Advanced Prostate Cancer
8 years ago
Common Treatments for Advanced Prostate Cancer
Enzalutamide
(Xtandi). It's a pill that blocks cells from receiving androgens. It's approved for men with advanced prostate cancer who have tried other hormone therapies. Surgery to Remove the Testicles (Orchiectomy) Your testicles make most of your testosterone.
Enzalutamide
(Xtandi). It's a pill that blocks cells from receiving androgens. It's approved for men with advanced prostate cancer who have tried other hormone therapies. Surgery to Remove the Testicles (Orchiectomy) Your testicles make most of your testosterone.
motosue
in
Advanced Prostate Cancer
8 years ago
Radiate pelvic lymph nodes or start Provenge and Enzalutamide ??
DaVinci RP in Nov 2012, Gleason 9 and PSA was 2.0 at 3 month check. Rad Onc advised salvage IMRT not likely to help as PSA was indicating systemic disease so we began continuous ADT which took PSA below .1 for the next 3 yrs. In Jan 2016 my PSA was again at 2.0 and we revisited the salvage RT option
DaVinci RP in Nov 2012, Gleason 9 and PSA was 2.0 at 3 month check. Rad Onc advised salvage IMRT not likely to help as PSA was indicating systemic disease so we began continuous ADT which took PSA below .1 for the next 3 yrs. In Jan 2016 my PSA was again at 2.0 and we revisited the salvage RT option
dave100
in
Advanced Prostate Cancer
8 years ago
Abiraterone or Enzalutamide in Advanced CRPC.
RESULTS: We found weak evidence that
enzalutamide
outperforms AA with prednisone in terms of OS in the pre-docetaxel and post-docetaxel settings.
RESULTS: We found weak evidence that
enzalutamide
outperforms AA with prednisone in terms of OS in the pre-docetaxel and post-docetaxel settings.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Duration of Treatment ... with Abiraterone Acetate or Enzalutamide.
A week ago I posted a study: "Abiraterone or
Enzalutamide
in Advanced CRPC." "There is strong evidence that
enzalutamide
outperforms AA with prednisone in terms of radiographic PFS and PSA progression and PSA response rate but not OS in the pre and post-docetaxel settings."
A week ago I posted a study: "Abiraterone or
Enzalutamide
in Advanced CRPC." "There is strong evidence that
enzalutamide
outperforms AA with prednisone in terms of radiographic PFS and PSA progression and PSA response rate but not OS in the pre and post-docetaxel settings."
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Role of free testosterone levels in mCRPC.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate,
enzalutamide
, cabozantinib, carboplatin or cabazitaxel.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate,
enzalutamide
, cabozantinib, carboplatin or cabazitaxel.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
ADT + Chemo vs ADT followed by Chemo
This was true in spite of the fact that most of the ADT only men were later treated with chemo once they became castration resistant, and many had abiraterone or
enzalutamide
. In other words, early chemo combined with ADT worked better than late chemo after ADT had stopped working.
This was true in spite of the fact that most of the ADT only men were later treated with chemo once they became castration resistant, and many had abiraterone or
enzalutamide
. In other words, early chemo combined with ADT worked better than late chemo after ADT had stopped working.
AlanMeyer
in
Advanced Prostate Cancer
8 years ago
PSMA imaging in prostate cancer
The toxicity seems to be low. " "... a survival benefit over approved standard therapies such as abiraterone,
enzalutamide
, radium-223-dichloride, docetaxel or cabazitaxel has not been shown.
The toxicity seems to be low. " "... a survival benefit over approved standard therapies such as abiraterone,
enzalutamide
, radium-223-dichloride, docetaxel or cabazitaxel has not been shown.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
Xtandi + Zytiga Fails To Deliver
Looks Like Myers was wrong about 2 better than 1 but I wonder if the combination would give a longer time to progression to mCRPC Gus http://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/93020-
enzalutamide
-in-combination-fails-to-improve-progression-free-survival-to-better-progression-free-survival-in-chemotherapy-naive-mcrpc-patients.html
Looks Like Myers was wrong about 2 better than 1 but I wonder if the combination would give a longer time to progression to mCRPC Gus http://www.urotoday.com/recent-abstracts/urologic-oncology/prostate-cancer/93020-
enzalutamide
-in-combination-fails-to-improve-progression-free-survival-to-better-progression-free-survival-in-chemotherapy-naive-mcrpc-patients.html
gusgold
in
Advanced Prostate Cancer
8 years ago
Additive inhibitory effects of simvastatin and enzalutamide ...
Combination of simvastatin and
enzalutamide
exerted additive growth inhibition in both cell lines accompanied with strong induction of autophagy in LNCaP.
Combination of simvastatin and
enzalutamide
exerted additive growth inhibition in both cell lines accompanied with strong induction of autophagy in LNCaP.
pjoshea13
in
Advanced Prostate Cancer
8 years ago
High Dose Testosterone as a treatment for the AR-V7 Blocking of Xtandi and Zytiga
Gus http://www.hematologyandoncology.net/index.php/archives/may-2016/current-understanding-of-resistance-to-abiraterone-and-
enzalutamide
-in-advanced-prostate-cancer/
Gus http://www.hematologyandoncology.net/index.php/archives/may-2016/current-understanding-of-resistance-to-abiraterone-and-
enzalutamide
-in-advanced-prostate-cancer/
gusgold
in
Advanced Prostate Cancer
8 years ago
Inflammation. [1] Neutrophil-to-Lymphocyte Ratio [NLR]
prostate cancer in men undergoing prostate needle biopsy." [7b] "In univariate analyses, NLR was a significant predictor of prostate cancer detection" [7c] "The GS 8-10 group had a significantly higher mean NLR compared to GS 5-6 (3.64 vs. 2.54 ...) and GS 7 (3.64 vs. 2.58 ...) patients." [8] Xtandi (
Enzalutamide
prostate cancer in men undergoing prostate needle biopsy." [7b] "In univariate analyses, NLR was a significant predictor of prostate cancer detection" [7c] "The GS 8-10 group had a significantly higher mean NLR compared to GS 5-6 (3.64 vs. 2.54 ...) and GS 7 (3.64 vs. 2.58 ...) patients." [8] Xtandi (
Enzalutamide
pjoshea13
in
Advanced Prostate Cancer
8 years ago
My most recent update
Now that we're over that hump, I am getting excellent results from
enzalutamide
, dropping my rise in PSA from 17 back to 0.85, then down to 0.08.
Now that we're over that hump, I am getting excellent results from
enzalutamide
, dropping my rise in PSA from 17 back to 0.85, then down to 0.08.
drdanfee
in
Prostate Cancer And Gay Men
8 years ago
Testosterone & Castration-Resistant PCa.
We investigate the historical basis for this modality, detail recent early-phase clinical trials that have demonstrated the feasibility and efficacy of this treatment, and describe an ongoing clinical trial comparing this modality to a currently accepted standard of care,
enzalutamide
, for castration-resistant
We investigate the historical basis for this modality, detail recent early-phase clinical trials that have demonstrated the feasibility and efficacy of this treatment, and describe an ongoing clinical trial comparing this modality to a currently accepted standard of care,
enzalutamide
, for castration-resistant
pjoshea13
in
Advanced Prostate Cancer
8 years ago
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