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Cabazitaxel
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Rising PSA after 7th infusion of Jevtana (Cabazitaxel)
Hi guys, I'm just wondering if anyone else was in a similar boat or could share any knowledge? So my dads psa has declined every cycle since he started Jevtana in August. He started with over 700 and it slowly went down every cycle all the way to 161 on 07/12/2020. Latest blood test was on the 5th of
Hi guys, I'm just wondering if anyone else was in a similar boat or could share any knowledge? So my dads psa has declined every cycle since he started Jevtana in August. He started with over 700 and it slowly went down every cycle all the way to 161 on 07/12/2020. Latest blood test was on the 5th of
Howmuchisthefish
in
Advanced Prostate Cancer
3 years ago
Opinions about chemotherapy. Running out of options
- The second schedule (which was actually used in a more formal clinical trial; thus more reliable evidence that it works) uses Carboplatin at a slightly lower dose (AUC 3, which was the dose you received with
Cabazitaxel
previously) on days 1 & 15.
- The second schedule (which was actually used in a more formal clinical trial; thus more reliable evidence that it works) uses Carboplatin at a slightly lower dose (AUC 3, which was the dose you received with
Cabazitaxel
previously) on days 1 & 15.
abmicro
in
Advanced Prostate Cancer
3 years ago
Keeping my arms, legs, hands and feet inside the ride
So we hit up insurance to see if I could do
cabazitaxel
and carboplatin. They denied i the combo(much to the chagrin of my MO) but approved Xofigo. Did one infusion Sept 28. Then my MO called and we discussed. Going to do 4 rounds
cabazitaxel
starting Oct 23 and hold off on Xofigo for now.
So we hit up insurance to see if I could do
cabazitaxel
and carboplatin. They denied i the combo(much to the chagrin of my MO) but approved Xofigo. Did one infusion Sept 28. Then my MO called and we discussed. Going to do 4 rounds
cabazitaxel
starting Oct 23 and hold off on Xofigo for now.
Maleko808
in
Advanced Prostate Cancer
4 years ago
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A Quick Update and Trial Questions
No blog post today, just a few points of interest from my recent past: Yesterday I started
cabazitaxel
chemo on the advice of Dr. Beltran of Dana Farber. I asked if it would be effective against neuroendocrine cancer, and she said it should.
No blog post today, just a few points of interest from my recent past: Yesterday I started
cabazitaxel
chemo on the advice of Dr. Beltran of Dana Farber. I asked if it would be effective against neuroendocrine cancer, and she said it should.
tom67inMA
in
Advanced Prostate Cancer
4 years ago
We’re still here!
Since February he has been on taxotere, carboplatin and
cabazitaxel
, and various combinations and dosages of all three. Despite some initial responses his PSA was 330 at chemo last Thursday, he is in immense pain.
Since February he has been on taxotere, carboplatin and
cabazitaxel
, and various combinations and dosages of all three. Despite some initial responses his PSA was 330 at chemo last Thursday, he is in immense pain.
joekaty
in
Advanced Prostate Cancer
3 years ago
Next Steps after Cabazitaxel and Xtandi
I then went to
Cabazitaxel
for 3 sessions but PSA continued to rise to 32. I went on a 3 week trip and used Xtandi again, and now my PSA is at 65.
I then went to
Cabazitaxel
for 3 sessions but PSA continued to rise to 32. I went on a 3 week trip and used Xtandi again, and now my PSA is at 65.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
PIK3CA mutation
I've had docetaxel (fail)
Cabazitaxel
(fail) carboplatin (fail) and the cancer no longer requires testosterone as a metabolite. I'm in deep shit and hoping there is still a get out of jail card I can use.
I've had docetaxel (fail)
Cabazitaxel
(fail) carboplatin (fail) and the cancer no longer requires testosterone as a metabolite. I'm in deep shit and hoping there is still a get out of jail card I can use.
Easey
in
Advanced Prostate Cancer
4 years ago
Resetting the Bar of Castration Resistance - Understanding Androgen Dynamics in Therapy Resistance and Treatment Choice in PCa
Cabazitaxel
versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer. N Engl J Med. 2019. 77. Smith MR, Parker CC, Tombal BF, et al.
Cabazitaxel
versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer. N Engl J Med. 2019. 77. Smith MR, Parker CC, Tombal BF, et al.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Cabazitaxel?
Cabazitaxel
- PSA continues to rise. Currently at 68. I know, I know PSA does not tell the whole story but it sure is a good indication that we have a problem. Dr Bryce discontinued my Zytiga and prednisone treatment and wants to start New.
Cabazitaxel
- PSA continues to rise. Currently at 68. I know, I know PSA does not tell the whole story but it sure is a good indication that we have a problem. Dr Bryce discontinued my Zytiga and prednisone treatment and wants to start New.
Hidden
in
Advanced Prostate Cancer
4 years ago
Switching gears due to insurance denial of treatment plan
My MO was set to give me
cabazitaxel
with carboplatin as docetaxel was not working. However, insurance denied this treatment as not being beneficial.
My MO was set to give me
cabazitaxel
with carboplatin as docetaxel was not working. However, insurance denied this treatment as not being beneficial.
Maleko808
in
Advanced Prostate Cancer
4 years ago
Docetaxel rechallenge in mPCa.
Among 227 patients who received first-line docetaxel for mCRPC between January 2011 and June 2019, 23 undergo rechallenge docetaxel after failure to androgen receptor targeting agents and/or
cabazitaxel
treatment.
Among 227 patients who received first-line docetaxel for mCRPC between January 2011 and June 2019, 23 undergo rechallenge docetaxel after failure to androgen receptor targeting agents and/or
cabazitaxel
treatment.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Radiation Therapy to the Sinus Area
I have started
cabazitaxel
and the initial results as reported are excellent. My MO (Mark Pormrantz at DFCI in Boston) and my treatment team have recommended radiation to attempt to kill any remaining mets in the sinus and around my skull.
I have started
cabazitaxel
and the initial results as reported are excellent. My MO (Mark Pormrantz at DFCI in Boston) and my treatment team have recommended radiation to attempt to kill any remaining mets in the sinus and around my skull.
SatuitMike
in
Advanced Prostate Cancer
4 years ago
Next steps with high PSA during Jevtana
Hi folks, I have had 3 infusions of
Cabazitaxel
over the past 10 weeks and I am due to go in tomorrow (Thursday, 8/27). My PSA has been rising dramatically, from 5.7 on 4/20 to 32.24 today. My scans did not show any decrease in Mets (S2, L2, T4,5,6,7), and a slight "shadow" of increase.
Hi folks, I have had 3 infusions of
Cabazitaxel
over the past 10 weeks and I am due to go in tomorrow (Thursday, 8/27). My PSA has been rising dramatically, from 5.7 on 4/20 to 32.24 today. My scans did not show any decrease in Mets (S2, L2, T4,5,6,7), and a slight "shadow" of increase.
tomtom9148
in
Advanced Prostate Cancer
4 years ago
The Difficult Question most all of us will face.
We discussed the options again and how they could buy time or not. 1) Continue with Chemo but use
Cabazitaxel
instead:
Cabazitaxel
he said was more toxic and may be less tolerated than Docetaxel. I asked how long would it push my date out. He said 6 months to maybe a year.
We discussed the options again and how they could buy time or not. 1) Continue with Chemo but use
Cabazitaxel
instead:
Cabazitaxel
he said was more toxic and may be less tolerated than Docetaxel. I asked how long would it push my date out. He said 6 months to maybe a year.
dpowellnt
in
Advanced Prostate Cancer
4 years ago
Free vs Total Testosterone? - Redux.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate, enzalutamide, cabozantinib, carboplatin or
cabazitaxel
.
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel, abiraterone acetate, enzalutamide, cabozantinib, carboplatin or
cabazitaxel
.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Adding carboplatin to chemotherapy for mCRPC in post-second generation hormone therapy setting: Impact on response and survival
Keywords: advanced prostate cancer;
cabazitaxel
; docetaxel; hormone refractory prostate cancer; second-generation hormone therapy. © 2020 Wiley Periodicals LLC.
Keywords: advanced prostate cancer;
cabazitaxel
; docetaxel; hormone refractory prostate cancer; second-generation hormone therapy. © 2020 Wiley Periodicals LLC.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Next Steps? Radium 223 or Jevanta (Cabazitaxel) - HELP - NEED ADVICE.
My friend is 56. Already gone thru Chemo (docetaxal), provenge, zytiga and xandi. MO wants him to start chemo which he doesnt want to do (again) and wants to know thoughts from others. Success (O.S) statistics with Radium 223? Running out of options. His PSA is rising but still low at .7 and imaging
My friend is 56. Already gone thru Chemo (docetaxal), provenge, zytiga and xandi. MO wants him to start chemo which he doesnt want to do (again) and wants to know thoughts from others. Success (O.S) statistics with Radium 223? Running out of options. His PSA is rising but still low at .7 and imaging
Longterm101
in
Advanced Prostate Cancer
4 years ago
Update on 6th Chemo session
May change me to
Cabazitaxel
. He is also going to request my initial biopsy for a test to determine if I would be eligible for any other treatments. (Thanks Tall Allen. It was exactly what you said he would ask so I was prepared.)
May change me to
Cabazitaxel
. He is also going to request my initial biopsy for a test to determine if I would be eligible for any other treatments. (Thanks Tall Allen. It was exactly what you said he would ask so I was prepared.)
dpowellnt
in
Advanced Prostate Cancer
4 years ago
Questions to ask at new consult tomorrow AM (and future ones)? Also info on clinical trials? Other MO's you like?
Now on
Cabazitaxel
plus Neulasta, had 2 treatments. PSA increased (might be flare, might not). No side effects docetaxel; miserable on
Cabazitaxel
. Still on Lupron and Xgeva. Second
cabazitaxel
delayed a week due to high AST. Alkaline phosphatase is 379; current AST 93. PSA 46.
Now on
Cabazitaxel
plus Neulasta, had 2 treatments. PSA increased (might be flare, might not). No side effects docetaxel; miserable on
Cabazitaxel
. Still on Lupron and Xgeva. Second
cabazitaxel
delayed a week due to high AST. Alkaline phosphatase is 379; current AST 93. PSA 46.
Barbara345
in
Advanced Prostate Cancer
4 years ago
Cabazitaxel and Prednisone, side effects, when?
Hi guys, I started
Cabazitaxel
on Thursday 6/17/20 and I’m waiting on “the other shoe to drop”. They are having me take 10 mg of Prednisone every morning, so I no longer feel the 4 pm fatigue, except by habit. Is that the purpose of the steroid, to stave off side effects?
Hi guys, I started
Cabazitaxel
on Thursday 6/17/20 and I’m waiting on “the other shoe to drop”. They are having me take 10 mg of Prednisone every morning, so I no longer feel the 4 pm fatigue, except by habit. Is that the purpose of the steroid, to stave off side effects?
tomtom9148
in
Advanced Prostate Cancer
4 years ago
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