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Expectations after six cycles of Taxotere
My husband was diagnosed with advanced prostate cancer nearly three years ago, receiving a regimen of ADT, which included abiraterone, Lupron and prednisone. When that no longer worked, he started first-line chemotherapy. He just completed his sixth cycle. His PSA dropped until the sixth infusion
My husband was diagnosed with advanced prostate cancer nearly three years ago, receiving a regimen of ADT, which included abiraterone, Lupron and prednisone. When that no longer worked, he started first-line chemotherapy. He just completed his sixth cycle. His PSA dropped until the sixth infusion
ronton2
in
Advanced Prostate Cancer
1 year ago
CRPC - causes and prevention of
This is the first time I have seen this explanation of why we become CRPC, do we know this to be true? This sounds like Gatenby's theory of killing off the weeds in a field allowing the non effected weeds to prosper. Does radiation kill these cells as well? This excerpt came from an NIH paper that
This is the first time I have seen this explanation of why we become CRPC, do we know this to be true? This sounds like Gatenby's theory of killing off the weeds in a field allowing the non effected weeds to prosper. Does radiation kill these cells as well? This excerpt came from an NIH paper that
Scout4answers
in
Advanced Prostate Cancer
1 year ago
Epigenetics - Heritability - Cadmium
Soon after diagnosis I joined a group headed by a man who viewed PCa as a modern disease with its origin in the womb. His bugbear was "Estrogen-like endocrine disrupting chemicals" (EEDC). I had come across the weird PCa risk factor of the second to fourth digit ratio, which seemed like voodoo science
Soon after diagnosis I joined a group headed by a man who viewed PCa as a modern disease with its origin in the womb. His bugbear was "Estrogen-like endocrine disrupting chemicals" (EEDC). I had come across the weird PCa risk factor of the second to fourth digit ratio, which seemed like voodoo science
pjoshea13
in
Fight Prostate Cancer
1 year ago
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ADT Recommendations
I'm probably looking at starting salvage radiation soon with 4-6 months of ADT. The doc suggests starting with Casodex and then two sequential Lupron shots. Is there a better way to do ADT for that period? I'd like to get my testosterone back quickly at the end of the treatment period if possible.
I'm probably looking at starting salvage radiation soon with 4-6 months of ADT. The doc suggests starting with Casodex and then two sequential Lupron shots. Is there a better way to do ADT for that period? I'd like to get my testosterone back quickly at the end of the treatment period if possible.
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
1 year ago
Does a big drop in PSA a month after the start of hormone treatment possibly represent a higher chance of cure?
Hi all, I have been researching and I have been wondering if big drops in PSA right after hormone treatment should give you more hope at a cure or if this does not change the situation at all? Father PSA of 226 dropped to 3 one month after Firmagon shot, and then 0.3 a month after that, and then 0.13
Hi all, I have been researching and I have been wondering if big drops in PSA right after hormone treatment should give you more hope at a cure or if this does not change the situation at all? Father PSA of 226 dropped to 3 one month after Firmagon shot, and then 0.3 a month after that, and then 0.13
FormulaRob
in
Advanced Prostate Cancer
1 year ago
PSA Climbing while on Zoladex and Abiraterone with Prednisone
I have an appointment with Oncologist today. Going to ask if i can switch the prednisone for dexamethasone. Not sure if they will approve it. I was scheduled to start Xgeva. As I have been diagnosed with osteoporosis due to having ADT since 2017. What other treatment should I look forward to having
I have an appointment with Oncologist today. Going to ask if i can switch the prednisone for dexamethasone. Not sure if they will approve it. I was scheduled to start Xgeva. As I have been diagnosed with osteoporosis due to having ADT since 2017. What other treatment should I look forward to having
Islandboy2021
in
Advanced Prostate Cancer
2 years ago
Seeking advice on course of action after Decipher Report
My Decipher Report came in and says that my Genomic Risk is High (0.66; 5 year risk of metastasis is 4.1%; 10 year risk of metastasis is 8.5%; and 15 year risk of prostate cancer mortality is 7.0%). I initially thought 7% sounded pretty good, but my RO said no, it's not, and he recommends getting going
My Decipher Report came in and says that my Genomic Risk is High (0.66; 5 year risk of metastasis is 4.1%; 10 year risk of metastasis is 8.5%; and 15 year risk of prostate cancer mortality is 7.0%). I initially thought 7% sounded pretty good, but my RO said no, it's not, and he recommends getting going
ElRanchoDePoisonIvy
in
Advanced Prostate Cancer
2 years ago
When do hot flashes end once ADT is suspended?
I was on ADT (Eligard) quarterly injections from January 2021 to November 2022 (two years). I am still experiencing the side effects of frequent hot flashes, low energy levels, weight gain, etc. I would just like to know when I might expect the hormones to have been "flushed-out" of my system and my
I was on ADT (Eligard) quarterly injections from January 2021 to November 2022 (two years). I am still experiencing the side effects of frequent hot flashes, low energy levels, weight gain, etc. I would just like to know when I might expect the hormones to have been "flushed-out" of my system and my
elwoodpdowd
in
Advanced Prostate Cancer
2 years ago
Any Dr Geo Followers
Is anyone on here a follower of Dr Geo Espinoza in NYC? He is a proponent of "neutraceuticals" and has a very good following. He offers some pricey but reportedly quality supplement regimens for PCA patients at all stages. I am considering starting the ADT/Regimen 03. Curious as to anyone else's experience
Is anyone on here a follower of Dr Geo Espinoza in NYC? He is a proponent of "neutraceuticals" and has a very good following. He offers some pricey but reportedly quality supplement regimens for PCA patients at all stages. I am considering starting the ADT/Regimen 03. Curious as to anyone else's experience
Jake2021
in
Advanced Prostate Cancer
2 years ago
The Use of Low Dose Estradiol to Ameliorate the Effects of ADT on Bone Mass Density
I have been conducting a long-term n of 1 trial since January 23, 2021 using lose dose estradiol (E2) gel to counteract the effects of androgen deprivation therapy (ADT) on bone mass density (BMD). I believe that I now have sufficient data to report that low dose transdermal E2, along with exercise and
I have been conducting a long-term n of 1 trial since January 23, 2021 using lose dose estradiol (E2) gel to counteract the effects of androgen deprivation therapy (ADT) on bone mass density (BMD). I believe that I now have sufficient data to report that low dose transdermal E2, along with exercise and
PhilipSZacarias
in
Advanced Prostate Cancer
2 years ago
An Important thing to know if considering Estrogen Therapy.
My experience using estrogen as my only form of ADT has been positive. However, when my psa started rising and I began to feel pain in my spine and pelvis my MO put me on Zometa (bone drug IV every 3 mo). Was it necessary? I have no idea. I now get mildly sick for about 36 hours after the infusion
My experience using estrogen as my only form of ADT has been positive. However, when my psa started rising and I began to feel pain in my spine and pelvis my MO put me on Zometa (bone drug IV every 3 mo). Was it necessary? I have no idea. I now get mildly sick for about 36 hours after the infusion
No_stone_unturned
in
Advanced Prostate Cancer
2 years ago
quick update
just spoke with my urology nurse consultant, my PSA is now 0.05, looks like the hormone treatment is working, looking like radiotherapy will start April/ May, I’ve got a personal trainer sorted out and a diet plan, and the effects of the hormone injection have eased, so I’m feeling positive Regards
just spoke with my urology nurse consultant, my PSA is now 0.05, looks like the hormone treatment is working, looking like radiotherapy will start April/ May, I’ve got a personal trainer sorted out and a diet plan, and the effects of the hormone injection have eased, so I’m feeling positive Regards
ukpete
in
Prostate Cancer Network
2 years ago
Bone Density - Dexa
I read somewhere that in the pre-Lupron days when DES (Diethylstilbestrol) was commonly used, bone loss was not a major issue. My 19-year history falls into three phases: i) continuous testosterone [T] ii) alternating 3-month periods of ADT & T iii) my version of BAT (LongBAT) - a single T injection
I read somewhere that in the pre-Lupron days when DES (Diethylstilbestrol) was commonly used, bone loss was not a major issue. My 19-year history falls into three phases: i) continuous testosterone [T] ii) alternating 3-month periods of ADT & T iii) my version of BAT (LongBAT) - a single T injection
pjoshea13
in
Fight Prostate Cancer
2 years ago
PSA keeps rising
My PCa timeline:April 2022 - DX with PCa, Gleason 3+4, PSA 18 Jun 2022 - PSA 28, given 3 month shot of lupron Aug 2022 - 20 sessions of IGRT Sep 2022 - PSA 0.56 Dec 2022 - PSA 1.6 Feb 2023 - PSA 5.3 Mar 4, 2023 - PSMA PET scan shows a single spot ("moderately tracer-avid focus at 6th rib ... suspicious
My PCa timeline:April 2022 - DX with PCa, Gleason 3+4, PSA 18 Jun 2022 - PSA 28, given 3 month shot of lupron Aug 2022 - 20 sessions of IGRT Sep 2022 - PSA 0.56 Dec 2022 - PSA 1.6 Feb 2023 - PSA 5.3 Mar 4, 2023 - PSMA PET scan shows a single spot ("moderately tracer-avid focus at 6th rib ... suspicious
John347
in
Advanced Prostate Cancer
2 years ago
Next Move?
Briefly, I had Radical Prostatectomy in February of 2018, ADT with Salvage Radiation ending in September of 2019 and undetectable PSA until August of 2022 when it increased to .09, then .12 in October, and .22 in December. Finally, .34 in March 2023. I just received this message from my Oncologist
Briefly, I had Radical Prostatectomy in February of 2018, ADT with Salvage Radiation ending in September of 2019 and undetectable PSA until August of 2022 when it increased to .09, then .12 in October, and .22 in December. Finally, .34 in March 2023. I just received this message from my Oncologist
Imp4t
in
Advanced Prostate Cancer
2 years ago
Energy and weight
Really struggling with fatigue and this weight. Up 20 lb..I think its a mental block..hard to get to the gym even though that is the answer. Ran 1,100 miles in 2019, backed off due to foot nerve operation..now 20 minutes in gym and I am exhausted. Just a couple months post radiation after failed surgery
Really struggling with fatigue and this weight. Up 20 lb..I think its a mental block..hard to get to the gym even though that is the answer. Ran 1,100 miles in 2019, backed off due to foot nerve operation..now 20 minutes in gym and I am exhausted. Just a couple months post radiation after failed surgery
runtrails
in
Advanced Prostate Cancer
2 years ago
Symptoms when ADT no longer works?
Hello, everyone! I have begun year two of stage 4 metastatic prostate cancer and I have BRCA2. Taking abiraterone + prednisone daily and Lupron shots twice a year. I am doing my best to live one day at a time but wonder what things will look like when the cancer becomes resistant. Does anybody know?
Hello, everyone! I have begun year two of stage 4 metastatic prostate cancer and I have BRCA2. Taking abiraterone + prednisone daily and Lupron shots twice a year. I am doing my best to live one day at a time but wonder what things will look like when the cancer becomes resistant. Does anybody know?
SandyBear2023
in
Advanced Prostate Cancer
2 years ago
Bone Health issues re:Bisphosphonnates, etc. ????
I'm back again for further research about the bone density medications, and now wondering about the use of bisphosphonates, denosumab and teriparatide? My PCP is suggesting these, but he's not current with the research about estrogen and testosterone use for PCa care. My backstory is that I'm suffering
I'm back again for further research about the bone density medications, and now wondering about the use of bisphosphonates, denosumab and teriparatide? My PCP is suggesting these, but he's not current with the research about estrogen and testosterone use for PCa care. My backstory is that I'm suffering
ragnar2020
in
Fight Prostate Cancer
2 years ago
Hormonal therapy and pain
Do you have experiences that hormonal therapy (ADT, Erleada etc) cause pain? What kind is it and have you stopped drugs? Or have you had a break and started it again? Or what has helped? My dad has been on ADT and Erleada for couple of months. Everything went fine but now he has quite bad pain ecpecially
Do you have experiences that hormonal therapy (ADT, Erleada etc) cause pain? What kind is it and have you stopped drugs? Or have you had a break and started it again? Or what has helped? My dad has been on ADT and Erleada for couple of months. Everything went fine but now he has quite bad pain ecpecially
Daughter17
in
Advanced Prostate Cancer
2 years ago
Stage 4 ~ Now Losing Blood Somewhere
Hi, my husband was diagnosed stage 4 with lymph node and bladder neck margins involvement 3/2018. He has done chemo, radiation, and hormone therapy over the past 5 years. His PSA increased quickly starting in October 2022 and by December it was 27. Hormone therapy isn’t working as before, it appears
Hi, my husband was diagnosed stage 4 with lymph node and bladder neck margins involvement 3/2018. He has done chemo, radiation, and hormone therapy over the past 5 years. His PSA increased quickly starting in October 2022 and by December it was 27. Hormone therapy isn’t working as before, it appears
drb1966
in
Advanced Prostate Cancer
2 years ago
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