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Baicalein 5,6,7-trimethyl ether, a flavonoid derivative, stimulates fatty acid β-oxidation in skin fibroblasts of X-ALD
The purpose of the present study is to identify bioactive compounds with potential for X-linked
adrenoleukodystrophy
(X-ALD) pharmacological therapy.
The purpose of the present study is to identify bioactive compounds with potential for X-linked
adrenoleukodystrophy
(X-ALD) pharmacological therapy.
monkeybus
in
AMN EASIER
5 years ago
Survey-based Natural History Study for Men and Women with AMN
Approximately 40-45 % of males and 50-65% of female carriers with X-linked
adrenoleukodystrophy
develop the adult-onset form called adrenomyeloneuropathy (AMN).
Approximately 40-45 % of males and 50-65% of female carriers with X-linked
adrenoleukodystrophy
develop the adult-onset form called adrenomyeloneuropathy (AMN).
SongStream
in
AMN EASIER
5 years ago
Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy
Recently, my doctor is using rapamycin test on ald children patients. The test is from this literature, but the literature was published in 2015. Is there any similar test conducted in other places? https://link.springer.com/article/10.1007/s00401-014-1378-8
Recently, my doctor is using rapamycin test on ald children patients. The test is from this literature, but the literature was published in 2015. Is there any similar test conducted in other places? https://link.springer.com/article/10.1007/s00401-014-1378-8
jayxie
in
Cure Parkinson's
5 years ago
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PLEASE READ THE BELOW INFO from UNIVERSITY of MINNESOTA
We are excited to share that the the Minnesota
Adrenoleukodystrophy
Registry Study (MARS) is open! Please click on the link to enroll your child. https://redcap.ahc.umn.edu/surveys/?s=MWFPYYRM8P Why are we conducting this research?
We are excited to share that the the Minnesota
Adrenoleukodystrophy
Registry Study (MARS) is open! Please click on the link to enroll your child. https://redcap.ahc.umn.edu/surveys/?s=MWFPYYRM8P Why are we conducting this research?
fightald
Administrator
in
Parents of ALD Newborns
6 years ago
Understanding My Childs Health
My newborn Child was diagnosed with X-linked
Adrenoleukodystrophy
back in June 2018. I was devastated and heart broken, all I could do was cry. I had 3 family members diagnosed with this same disease,one being my father that passed away in 2014 at the age of 44.
My newborn Child was diagnosed with X-linked
Adrenoleukodystrophy
back in June 2018. I was devastated and heart broken, all I could do was cry. I had 3 family members diagnosed with this same disease,one being my father that passed away in 2014 at the age of 44.
__Kyrie0619__
in
Parents of ALD Newborns
6 years ago
Viking Therapeutics Announces Top-Line Results from Proof-of-Concept Study of VK0214 in In Vivo Model of X-Linked Adrenoleukodystrophy
ABCD2 making steady progress... http://ir.vikingtherapeutics.com/2017-10-04-Viking-Therapeutics-Announces-Top-Line-Results-from-Proof-of-Concept-Study-of-VK0214-in-In-Vivo-Model-of-X-Linked-
Adrenoleukodystrophy
-X-ALD
ABCD2 making steady progress... http://ir.vikingtherapeutics.com/2017-10-04-Viking-Therapeutics-Announces-Top-Line-Results-from-Proof-of-Concept-Study-of-VK0214-in-In-Vivo-Model-of-X-Linked-
Adrenoleukodystrophy
-X-ALD
wilburlois15
in
AMN EASIER
7 years ago
Michael Conway - Adrenoleukodystrophy (ALD)
Dear HealthUnlocked - My name is Michael Conway and I have
Adrenoleukodystrophy
(ALD). I have trying to raise awareness of this condition by speaking to ALD Life, Raremark, CLIMB and local newspapers. I can send anyone links / attachment to my ALD story if anyone is interested.
Dear HealthUnlocked - My name is Michael Conway and I have
Adrenoleukodystrophy
(ALD). I have trying to raise awareness of this condition by speaking to ALD Life, Raremark, CLIMB and local newspapers. I can send anyone links / attachment to my ALD story if anyone is interested.
MichaelConway
in
AMN EASIER
7 years ago
Lenti-D investigational gene therapy in boys under 18 years old results.
This gene addition should result in the production of functional
adrenoleukodystrophy
protein (ALDP), a protein critical for the breakdown of very long chain fatty acids (VLCFAs). Buildup of VLCFAs in the central nervous system contributes to neurodegeneration in CALD.
This gene addition should result in the production of functional
adrenoleukodystrophy
protein (ALDP), a protein critical for the breakdown of very long chain fatty acids (VLCFAs). Buildup of VLCFAs in the central nervous system contributes to neurodegeneration in CALD.
monkeybus
in
AMN EASIER
7 years ago
Tauroursodeoxycholic acid
http://link.springer.com/article/10.1007/s00401-016-1655-9 Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked
adrenoleukodystrophy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030606/ Alzheimer's, Parkinsons's, Huntington's, ALD, AMN
http://link.springer.com/article/10.1007/s00401-016-1655-9 Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked
adrenoleukodystrophy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030606/ Alzheimer's, Parkinsons's, Huntington's, ALD, AMN
monkeybus
in
AMN EASIER
8 years ago
Viking Therapeutics' VK0214 Receives FDA Orphan Drug Designation for the Treatment of X-Linked Adrenoleukodystrophy
Not holding my breath but it's a step forward http://www.checkorphan.org/news/viking-therapeutics-vk0214-receives-fda-orphan-drug-designation-for-the-treatment-of-x-linked-
adrenoleukodystrophy
#
Not holding my breath but it's a step forward http://www.checkorphan.org/news/viking-therapeutics-vk0214-receives-fda-orphan-drug-designation-for-the-treatment-of-x-linked-
adrenoleukodystrophy
#
wilburlois15
in
AMN EASIER
8 years ago
Valproic Acid
Think he just wanted me out of the room . . http://m.hmg.oxfordjournals.org/content/19/10/2005.full Valproic acid induces antioxidant effects in X-linked
adrenoleukodystrophy
A specific HDAC inhibitor is Valproic acid (VPA), which is a class I-selective HDAC inhibitor with anticonvulsive (anti-seizure
Think he just wanted me out of the room . . http://m.hmg.oxfordjournals.org/content/19/10/2005.full Valproic acid induces antioxidant effects in X-linked
adrenoleukodystrophy
A specific HDAC inhibitor is Valproic acid (VPA), which is a class I-selective HDAC inhibitor with anticonvulsive (anti-seizure
monkeybus
in
AMN EASIER
8 years ago
Metformin
Recent research "Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked
adrenoleukodystrophy
involves AMP-activated protein kinase." Pharmacological activation of AMPK can rescue the mitochondrial dysfunction and inhibit the pro-inflammatory response.
Recent research "Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked
adrenoleukodystrophy
involves AMP-activated protein kinase." Pharmacological activation of AMPK can rescue the mitochondrial dysfunction and inhibit the pro-inflammatory response.
SongStream
in
AMN EASIER
8 years ago
Another drug
About
adrenoleukodystrophy
Adrenoleukodystrophy
, also known as
adrenoleukodystrophy
with linkage to X (X-ALD) chromosome is a neurometabolic disorder inheritance linkage to X recessive, caused by mutations in the gene ABCD1 .
About
adrenoleukodystrophy
Adrenoleukodystrophy
, also known as
adrenoleukodystrophy
with linkage to X (X-ALD) chromosome is a neurometabolic disorder inheritance linkage to X recessive, caused by mutations in the gene ABCD1 .
monkeybus
in
AMN EASIER
8 years ago
DHEA
Dehydroepiandrosterone up-regulates the
Adrenoleukodystrophy
-related gene (ABCD2) independently of PPARalpha in rodents. http://www.ncbi.nlm.nih.gov/pubmed/17686565 Here, we explored the in vitro and in vivo effects of DHEA on the expression of peroxisomal ABC transporters.
Dehydroepiandrosterone up-regulates the
Adrenoleukodystrophy
-related gene (ABCD2) independently of PPARalpha in rodents. http://www.ncbi.nlm.nih.gov/pubmed/17686565 Here, we explored the in vitro and in vivo effects of DHEA on the expression of peroxisomal ABC transporters.
monkeybus
in
AMN EASIER
9 years ago
Antioxidants Halt Axonal Degeneration in a Mouse Model of X-Adrenoleukodystrophy
Antioxidants Halt Axonal Degeneration in a Mouse Model of X-
Adrenoleukodystrophy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229843/ Oxidative stress underlying axonal degeneration in
adrenoleukodystrophy
: A paradigm for multifactorial neurodegenerative diseases?
Antioxidants Halt Axonal Degeneration in a Mouse Model of X-
Adrenoleukodystrophy
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229843/ Oxidative stress underlying axonal degeneration in
adrenoleukodystrophy
: A paradigm for multifactorial neurodegenerative diseases?
monkeybus
in
AMN EASIER
9 years ago
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