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Chemotherapy or Zytiga or both? Metastatic or Locally Advanced Prostate Cancer?
Unsure what to do re: the chemo as local oncologists (at a center of excellence) won’t prescribe because they say husband is not technically metastatic and they feel ADT +
Abiraterone
plus radiation therapy is an aggressive plan. Thoughts?
Unsure what to do re: the chemo as local oncologists (at a center of excellence) won’t prescribe because they say husband is not technically metastatic and they feel ADT +
Abiraterone
plus radiation therapy is an aggressive plan. Thoughts?
StephH72
in
Advanced Prostate Cancer
2 years ago
Neuropathy and cabazitaxal
The chemo is the last ditch effort as he has failed all other SOC (Xtandi,
Abiraterone
, Docetaxal, ADT- resistant now). Question- could this chemo make neuropathy worse, and is it something we should be concerned with.
The chemo is the last ditch effort as he has failed all other SOC (Xtandi,
Abiraterone
, Docetaxal, ADT- resistant now). Question- could this chemo make neuropathy worse, and is it something we should be concerned with.
Sipj
in
Advanced Prostate Cancer
2 years ago
Abiraterone and Enzalutamide Raise Metabolic, Cardiovascular Adverse Event Risks
Abiraterone
and enzalutamide did not increase the risk of hypertensive adverse events.
Abiraterone
and enzalutamide did not increase the risk of hypertensive adverse events.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
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New article on Olaparib and Abiraterone Phase 2 trial - patient reported responses
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00498-3/fulltext?dgcid=raven_jbs_aip_email
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(22)00498-3/fulltext?dgcid=raven_jbs_aip_email
spw1
in
Advanced Prostate Cancer
2 years ago
Determinants of PSA Response to Bipolar Androgen Therapy [BAT]
Responders were more likely to have had a radical prostatectomy as definitive therapy and were more likely to have been treated with an androgen receptor (AR) antagonist (enzalutamide or apalutamide) immediately prior to BAT (compared to
abiraterone
).
Responders were more likely to have had a radical prostatectomy as definitive therapy and were more likely to have been treated with an androgen receptor (AR) antagonist (enzalutamide or apalutamide) immediately prior to BAT (compared to
abiraterone
).
pjoshea13
in
Fight Prostate Cancer
1 year ago
define "metastatic"
(https://pubmed.ncbi.nlm.nih.gov/35371297) Wherein this statement is found " survival of metastatic HSPC can be improved with the addition to ADT of any one of docetaxel,
abiraterone
, acetate, prednisone combination, apalutamide, or darolutamide in combination with docetaxel".
(https://pubmed.ncbi.nlm.nih.gov/35371297) Wherein this statement is found " survival of metastatic HSPC can be improved with the addition to ADT of any one of docetaxel,
abiraterone
, acetate, prednisone combination, apalutamide, or darolutamide in combination with docetaxel".
runtrails
in
Advanced Prostate Cancer
2 years ago
Starting Lupron ... Again
We discussed the studies pertaining to adding a second level ADT med, like
Abiraterone
, that showed a potential survival advantage. We also discussed adding Erleada and
Abiraterone
. Ultimately, I elected not to add anything to the Lupron.
We discussed the studies pertaining to adding a second level ADT med, like
Abiraterone
, that showed a potential survival advantage. We also discussed adding Erleada and
Abiraterone
. Ultimately, I elected not to add anything to the Lupron.
fireandice123
in
Advanced Prostate Cancer
2 years ago
Evidence that the Medical Community is Failing Prostate Cancer Patients !!
But Don Pescado, you may argue, STAMPEDE only proved the use of
abiraterone
plus ADT in MHSPC in 2017... https://prostatecancerinfolink.net/2017/09/13/update-on-stampede-data-on-
abiraterone
-adt-in-m0-patients-with-hspc/ EXACTLY !!!
But Don Pescado, you may argue, STAMPEDE only proved the use of
abiraterone
plus ADT in MHSPC in 2017... https://prostatecancerinfolink.net/2017/09/13/update-on-stampede-data-on-
abiraterone
-adt-in-m0-patients-with-hspc/ EXACTLY !!!
NPfisherman
in
Fight Prostate Cancer
2 years ago
Side Effects of Docetaxel vs Cabazitaxel
Been at this for over 6 years now, diagnosed at stage 4 and ever since on ADT, plus 6 cycles of Docetaxel,
Abiraterone
and Enzalutamide. Looks like its time for Cabazitaxel. My doctor is recommending that as the next treatment.
Been at this for over 6 years now, diagnosed at stage 4 and ever since on ADT, plus 6 cycles of Docetaxel,
Abiraterone
and Enzalutamide. Looks like its time for Cabazitaxel. My doctor is recommending that as the next treatment.
EdBacon
in
Advanced Prostate Cancer
2 years ago
Androgen receptor mutations for precision medicine in prostate cancer - Endocrine-Related Cancer, Review Article, Published: 17 Aug 2022
[/i] [i]Keywords:
abiraterone
; androgen receptor; antiandrogen; mutation; steroid[/i] . . .
[/i] [i]Keywords:
abiraterone
; androgen receptor; antiandrogen; mutation; steroid[/i] . . .
cujoe
in
Fight Prostate Cancer
2 years ago
Tough Questions
He has gone through docetaxal (almost killed him), Lupron, Xtandi,
Abiraterone
, Xgeva, immunotherapy, palliative radiation, and next was going to be cabazitaxal. His labs came back with his platelets at51, too low for treatment.
He has gone through docetaxal (almost killed him), Lupron, Xtandi,
Abiraterone
, Xgeva, immunotherapy, palliative radiation, and next was going to be cabazitaxal. His labs came back with his platelets at51, too low for treatment.
Sipj
in
Advanced Prostate Cancer
2 years ago
Breaking androgen receptor addiction of prostate cancer by targeting different functional domains in the treatment of advanced disease
This is technical at first but if you work your way through it there are excellent data on why
abiraterone
, apilutamide, Enzalutimide fail, and how pretty awesome darolutamide is, but its not invincible.
This is technical at first but if you work your way through it there are excellent data on why
abiraterone
, apilutamide, Enzalutimide fail, and how pretty awesome darolutamide is, but its not invincible.
KocoPr
in
Advanced Prostate Cancer
2 years ago
Prolactin & Abiraterone
Keywords:
abiraterone
; castration resistant; prognosis; prolactin; prostate cancer. © 2022 Wiley Periodicals LLC.
Keywords:
abiraterone
; castration resistant; prognosis; prolactin; prostate cancer. © 2022 Wiley Periodicals LLC.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Am I missing any options / pipeline developments that could allow me to stop HT?
I am on monthly Degarelix and daily
Abiraterone
. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
I am on monthly Degarelix and daily
Abiraterone
. Clearly I love my PSA having the less than sign and want it to stay that way but am starting to be miserable with how much the HT is changing me. it’s not just the no libido which on its own is a QOL disaster but the energy and drive loss.
Brysonal
in
Advanced Prostate Cancer
2 years ago
Got my genomic analysis - sounds like there are possibilities?
I'm high volume metastatic cancer, currently on Lupron, had to stop
abiraterone
due to liver numbers off, & had 1st Docetaxel chemo a week ago. Sounds like Keytruda could be beneficial as immunotherapy. Possibly concurrent with docetaxel? What should I get out of these results?
I'm high volume metastatic cancer, currently on Lupron, had to stop
abiraterone
due to liver numbers off, & had 1st Docetaxel chemo a week ago. Sounds like Keytruda could be beneficial as immunotherapy. Possibly concurrent with docetaxel? What should I get out of these results?
rsgdmd
in
Advanced Prostate Cancer
2 years ago
Anti-PCa effects of statins, prednisone, aspirin and denosumab (Xgeva)
I will be getting it in late December, and already get prednisone in conjunction with
abiraterone
, and am on a statin I used to need but no longer for lipid purposes. Does anyone have info about low dose aspirin with regard to anti-PCa effects?
I will be getting it in late December, and already get prednisone in conjunction with
abiraterone
, and am on a statin I used to need but no longer for lipid purposes. Does anyone have info about low dose aspirin with regard to anti-PCa effects?
Derf4223
in
Advanced Prostate Cancer
1 year ago
Where should I purchase Abiraterone from
Where is the best place to purchase
Abiraterone
from? Need to take 1000 mgs a day on an empty stomach for 1.5 to 2 yrs. Yearly cost with my Medicare part D drug plan from Wellcare is very high. Good RX looks promising but will their price last over time?
Where is the best place to purchase
Abiraterone
from? Need to take 1000 mgs a day on an empty stomach for 1.5 to 2 yrs. Yearly cost with my Medicare part D drug plan from Wellcare is very high. Good RX looks promising but will their price last over time?
snugrose
in
Advanced Prostate Cancer
2 years ago
Pluvicto increases radiographic progression-free survival (rPFS) before chemo
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (
abiraterone
, enzalutamide, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
https://clinicaltrials.gov/ct2/show/NCT04689828 It tested whether giving Pluvicto increases radiographic progression-free survival (rPFS) in men who: (1) have failed one of the second-line hormonals (
abiraterone
, enzalutamide, darolutamide, or apalutamide) (2) have not had taxane chemo (3) are metastatic
Tall_Allen
in
Advanced Prostate Cancer
1 year ago
NEXT STEP IMRT
I'm also scheduled to talk with my Uro Oncologist on 8/3/2022 about starting either enzalutamide or
abiraterone
+ prednisone. Plan is to hit it hard up front to delay BCR as long as possible. 7/27/22 - PSA 0.01. T - 11.
I'm also scheduled to talk with my Uro Oncologist on 8/3/2022 about starting either enzalutamide or
abiraterone
+ prednisone. Plan is to hit it hard up front to delay BCR as long as possible. 7/27/22 - PSA 0.01. T - 11.
GMan-62
in
Advanced Prostate Cancer
2 years ago
Pluvicto plus Xtandi
I’ve run the gambit of Bicalutamide, Docetaxel,
Abiraterone
, Cabazitaxel, still taking Lupron and Zometa. At the beginning of June I started Enzalutamide (Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness.
I’ve run the gambit of Bicalutamide, Docetaxel,
Abiraterone
, Cabazitaxel, still taking Lupron and Zometa. At the beginning of June I started Enzalutamide (Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness.
Rondief
in
Advanced Prostate Cancer
2 years ago
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