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Scleroderma & Raynaud's UK (SRUK)

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How does Venlafaxine and amitriptyline affect Raynauds

Cloudsurfer profile image
6 Replies

Has anyone had experience of using low level venlafaxine and/or amitriptyline 10mg? Did you find it made your raynaud symptoms worse initially? If so did this pass or was it a cause for concern?

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Cloudsurfer
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6 Replies
marie5454 profile image
marie5454

I take amitriptyline 20mg, it does help me sleep but not helping my symptoms through the day, read that it's just a front line treatment though so maybe need something else. I can feel everything getting worse lately

Berniz profile image
Berniz

I have been using Nephedipine which is not an antidepreesant. I find it very helpful.

beaglab profile image
beaglab

Hi Cloudsurfer, I do not know anything about those medicines, but I think you need to be careful. The Raynaud's association recommends taking gingko biloba twice daily. Other experts, including the book, "Niacin, the Real Story" provide valuable info on the use of Niacin, the kind that causes a flush, and is to be taken twice a day, usually 500 mgs. in the morning and 500 mgs. in the evening. I think the meds you are asking about can cause some dangerous side effects. Please take care of yourselves.

bookworm profile image
bookworm

Hiya amptriptyline will mainly help at night time. I think medication can affect everyone differently and its worth being careful with alternatives check with a pharmacist or dr. I think if your not sure about medication if you see a pharmacy which not attached to your pharmacy for a medication review. Don't be influenced by others. Or speak to the professions concerned who prescribed your medication. Maybe ask the SRUK helpline.

Be careful stress and anxiety can trigger Raynauds attacks.

Cloudsurfer profile image
Cloudsurfer

Thanks for your replies. I appreciate it. The problem is the venlafaxine is required for severe depression but seems to be causing the raynaud's symptoms to flare up. The amitriptyline is required for facial burning and feet burning at night as well as a sleep aid. Trying to combine medication to tackle multiple conditions is proving very difficult to say the least.

X-Woman profile image
X-Woman

I'm on max dose Venlafaxine (75mg 4 times a day) for EM and it's been a lifesaver for me. My EM has gotten better by at least 75% and I couldn't have coped without it.

Ami gave me nightmares and I kept waking up choking.

Neither affected my Raynaud's symptoms. For Raynaud's the only thing I found of any long term help has been Captopril. I take 12.5mg 3 times a day, increasing to 4 times a day during winter. They don't stop my symptoms but my God they help a lot that's for sure.

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