Ribociclib

[Bluemoon46]

Is anybody taking this for advanced breast cancer.

[Thrifty51]

Hi Bluemoon,

I'm in my third round of Ribociclib AKA Kisqali. My doc decided this would be better for me than Ibrance because there is less of a chance of blood clots which I had while in rehab for two broken hips. I have had the usual fatigue, chills, low wbc etc so this third round I reduced to taking 2 pills each day instead of 3. So far it has been better as far as fatigue is concerned. I am halfway through the cycle so I'm hoping that I tolerate it better than full dosage. I have a disabled son that I care for so I must keep on keeping on.

I think there are a few ladies on here that take Ribociclib but not many.

Blessings to you!!

[Bluemoon46 in reply to Thrifty51]

Thank you for replying. I am taking Kisqali with anastrozole to reduce the tumour so it can be operated on. It is in the skin under my breast. I too am on 2 tablets and on my third cycle. The first two cycles slowed my heart rate down.

[Thrifty51 in reply to Bluemoon46]

Have you discussed whether you will continue taking it after the surgery? I assume you will have scans soon to see if it is working? I pray that the surgery will be all you need.

I had EKGs every two weeks for the first two months to keep an eye on the heart. After that they stopped. But I will pay more attention to the heart rate. Mine has always been fast anyway.

All my best to you

[Bluemoon46 in reply to Thrifty51]

As my cancer is on the skin they can see if it is working or not. I can’t see much change but only on my third cycle. Apparently if it reduces it will be easier to operate.

[SoCalLady]

I'm on my 24th cycle. Only have bone mets and Ribo has never reduced them; they have only been kept stable according to scans. Meet with my Onc tomorrow to see what my markers look like since they rising. I'll Let you know what happens.

[Bluemoon46 in reply to SoCalLady]

Thank you. Good luck tomorrow.

[Thrifty51 in reply to SoCalLady]

SoCalLady

Hugs and prayers for you today.

24 cycles is great!!

[SoCalLady in reply to Thrifty51]

Bluemoon and Thrifty. Markers up again 30 - 50 points. Onc still wants to add Faslodex to the regiment, which I'm okay with, except for the expense, so I came armed with some possible clinical trials that include Faslodex. I think I surprised him, but he's having his office do some research on them. I explained to him if he put me on it now, I probably wouldn't be eligible for a trial. He agreed. I find it interesting that both of you ladies are on 2 Ribo pills a day, I'm still taking 3. Like Ibrance, did your doctors think or is there evidence that a reduced dosage is as effective as the max dosage?

[Bluemoon46 in reply to SoCalLady]

I have no idea if it is as effective as the full dose but it is quite common to reduce the dose I believe. I gather you are not in the UK if you are concerned about the cost of drugs.

[Thrifty51 in reply to SoCalLady]

My markers have also jumped around some but the last time they were down a little. My doc said it was just as effective and hopefully without a lot of the fatigue. However, I am not sure about the fatigue since I'm just in the middle of my second week of reduction.

I have not personally read of any studies done with the reduction.